90178-82-8 Usage
Uses
Used in Pharmaceutical Industry:
3-Formyl-4-nitrobenzonitrile is used as a synthetic intermediate for the preparation of various pharmaceuticals with a large spectrum of activity. Its unique structure allows for the development of compounds with diverse therapeutic properties, making it a valuable component in the creation of new medications.
Check Digit Verification of cas no
The CAS Registry Mumber 90178-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,1,7 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 90178-82:
(7*9)+(6*0)+(5*1)+(4*7)+(3*8)+(2*8)+(1*2)=138
138 % 10 = 8
So 90178-82-8 is a valid CAS Registry Number.
90178-82-8Relevant academic research and scientific papers
Development of a Practical Synthesis of a Farnesyltransferase Inhibitor
Shi, Zhongping,Fan, Junying,Kronenthal, David R.,Mudryk, Boguslaw M.
, p. 1534 - 1540 (2018/11/23)
The development of a new and practical synthesis for a farnesyltransferase inhibitor 1 is described. The new route started from 2-nitro-5-cyanotoluene (9) and afforded desired 1 in eight chemical transformations. The key step involved formation of sulfonamide 13 from a hindered β-hydroxyamine 12 through an in situ protection of the hydroxyl group by forming TMS ether. Ultimately, this new route was successfully demonstrated to generate >10 kg of API in 29% overall yield.
