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5382-18-3

5382-18-3

Identification

  • Product Name:4-Chloropiperidine

  • CAS Number: 5382-18-3

  • EINECS:

  • Molecular Weight:119.594

  • Molecular Formula: C5H10ClN

  • HS Code:2933399090

  • Mol File:5382-18-3.mol

Synonyms:4-Chloropiperidine;

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Safety information and MSDS view more

  • Signal Word:Danger

  • Hazard Statement:H226 Flammable liquid and vapourH314 Causes severe skin burns and eye damage H318 Causes serious eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:TRC
  • Product Description:4-Chloropiperidine
  • Packaging:1g
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:4-Chloropiperidine
  • Packaging:250mg
  • Price:$ 55
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Chloropiperidine >97.0%(GC)(T)
  • Packaging:25g
  • Price:$ 275
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Chloropiperidine >97.0%(GC)(T)
  • Packaging:5g
  • Price:$ 92
  • Delivery:In stock
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  • Manufacture/Brand:J&W Pharmlab
  • Product Description:4-Chloro-piperidine 97%
  • Packaging:5g
  • Price:$ 39
  • Delivery:In stock
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  • Manufacture/Brand:Chem-Impex
  • Product Description:4-Chloropiperidine,≥97%(GC)Hazmat ≥97%(GC)
  • Packaging:5G
  • Price:$ 104
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:4-Chloropiperidine
  • Packaging:10 g
  • Price:$ 200
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:4-Chloropiperidine
  • Packaging:5 g
  • Price:$ 125
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:4-Chloropiperidine
  • Packaging:2 g
  • Price:$ 70
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:4-Chloropiperidine
  • Packaging:50 g
  • Price:$ 750
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

Synthesis of 1-tert-butyl-4-chloropiperidine: Generation of an N-tert-butyl group by the reaction of a dimethyliminium salt with methylmagnesium chloride

Amato, Joseph S.,Chung, John Y. L.,Cvetovich, Raymond J.,Gong, Xiaoyi,McLaughlin, Mark,Reamer, Robert A.

, p. 1930 - 1933 (2007/10/03)

(Chemical Equation Presented) Two efficient routes to 1-tert-butyl-4- chloropiperidine are described. In the first route, the key thionyl chloride mediated chlorination reaction features the use of tetrabutyl-ammonium chloride as an additive that effectively suppresses the formation of an elimination-derived side product. In the second route, a novel alternative synthesis of 1-tert-butyl-4-chloropiperidine was developed in which the tertiary butyl group on the nitrogen is efficiently generated through the addition of methylmagnesium chloride to a dimethyliminium salt in 71% overall yield.

Process route upstream and downstream products

Process route

4-chloro-1-methylpiperidine
5570-77-4

4-chloro-1-methylpiperidine

4-chloro piperidine
5382-18-3

4-chloro piperidine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 3 h / 80 °C
1.2: NaBr / methanol / 18 h / 20 °C
2.1: 89 percent / acetonitrile / 18 h / 73 °C
3.1: tetrahydrofuran / 8 h / -15 - 20 °C
With carbonochloridic acid 1-chloro-ethyl ester; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile;
4-chloro-1-isopropylidene-piperidinium; bromide

4-chloro-1-isopropylidene-piperidinium; bromide

methylmagnesium chloride
676-58-4

methylmagnesium chloride

4-chloro piperidine
5382-18-3

4-chloro piperidine

1-tert-butyl-4-chloropiperidine
5570-81-0

1-tert-butyl-4-chloropiperidine

Conditions
Conditions Yield
In tetrahydrofuran; at -15 - 20 ℃; for 8h;
4-chloropiperidine hydrobromide

4-chloropiperidine hydrobromide

4-chloro piperidine
5382-18-3

4-chloro piperidine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 89 percent / acetonitrile / 18 h / 73 °C
2: tetrahydrofuran / 8 h / -15 - 20 °C
In tetrahydrofuran; acetonitrile;
4-chloro piperidine
5382-18-3

4-chloro piperidine

Conditions
Conditions Yield
4-chloro piperidine
5382-18-3

4-chloro piperidine

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

4-chloro-1-((4-nitrophenyl)sulfonyl)piperidine

4-chloro-1-((4-nitrophenyl)sulfonyl)piperidine

Conditions
Conditions Yield
With pyridine; In tetrahydrofuran; at 60 ℃; for 0.5h;
96%
With pyridine; In tetrahydrofuran; at 60 ℃; for 0.333333h;
96%
4-chloro piperidine
5382-18-3

4-chloro piperidine

2-chloro-1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)ethanone
1310098-52-2

2-chloro-1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)ethanone

2-(4-chloropiperidin-1-yl)-1-[5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl]ethanone

2-(4-chloropiperidin-1-yl)-1-[5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl]ethanone

Conditions
Conditions Yield
With dmap; potassium iodide; In acetone; at 40 ℃; for 2h;
80%
4-chloro piperidine
5382-18-3

4-chloro piperidine

3-[1-(2-chloroacetyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2H-chromen-2-one

3-[1-(2-chloroacetyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2H-chromen-2-one

C<sub>25</sub>H<sub>24</sub>ClN<sub>3</sub>O<sub>3</sub>

C25H24ClN3O3

Conditions
Conditions Yield
With piperazine; potassium iodide; In acetone; at 50 ℃; for 5h;
51%
4-chloro piperidine
5382-18-3

4-chloro piperidine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-chloro-1-tosylpiperidine

4-chloro-1-tosylpiperidine

Conditions
Conditions Yield
With pyridine; at 20 ℃; for 19h; Inert atmosphere;
99%
4-chloro piperidine
5382-18-3

4-chloro piperidine

4-fluorobenzonitrile
1194-02-1,143234-87-1

4-fluorobenzonitrile

4-(4-chloropiperidin-1-yl)benzonitrile
1613627-45-4

4-(4-chloropiperidin-1-yl)benzonitrile

Conditions
Conditions Yield
With potassium carbonate; In dimethyl sulfoxide; at 90 - 120 ℃; Inert atmosphere;
With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 8h;
4-chloro piperidine
5382-18-3

4-chloro piperidine

C<sub>12</sub>H<sub>13</sub>Br<sub>2</sub>NO

C12H13Br2NO

C<sub>17</sub>H<sub>22</sub>BrClN<sub>2</sub>O

C17H22BrClN2O

Conditions
Conditions Yield
With potassium phosphate; copper(I) bromide dimethylsulfide complex; triphenylphosphine; In toluene; at 25 ℃; for 23h; Inert atmosphere; Sealed tube;
85%

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