5382-18-3

Basic information

• Product Name: 4-Chloropiperidine
• Synonyms: 4-CHLOROPIPERIDINE
• CAS NO: 5382-18-3
• Molecular Formula: C₅H₁₀ClN
• Molecular Weight: 119.59
• Mol File: 5382-18-3.mol

Chemical Properties

• Boiling Point: 60 °C / 11mmHg
• Flash Point: 48 °C
• Appearance: /
• Density: 1.09
• Vapor Pressure: 1.24mmHg at 25°C
• Refractive Index: 1.4880-1.4920
• Storage Temp.: 0-10°C
• PKA: 9.47±0.10(Predicted)
• CAS DataBase Reference: 4-Chloropiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropiperidine(5382-18-3)
• EPA Substance Registry System: 4-Chloropiperidine(5382-18-3)

Safety Data

• RIDADR: 2920
• HazardClass: 8/3
• PackingGroup: II
• Hazardous Substances Data: 5382-18-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloropiperidine is used as a key intermediate for the synthesis of various medicines, contributing to the development of new therapeutic agents. Its unique chemical structure allows for the creation of a wide range of pharmaceutical compounds, enhancing the industry's ability to address diverse health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloropiperidine serves as a building block for the synthesis of compounds used in pest control and crop protection. Its incorporation into these products helps improve agricultural yields by combating harmful pests and diseases.
Used in Organic Synthesis:
4-Chloropiperidine is utilized as a versatile starting material in organic synthesis, enabling the production of a variety of organic compounds for different applications. Its reactivity and functional group compatibility make it a valuable component in the synthesis of specialty chemicals and other complex organic molecules.

InChI:InChI=1/C5H10ClN/c6-5-1-3-7-4-2-5/h5,7H,1-4H2

Upstream product

• 676-58-4 methylmagnesium chloride 
• 5570-77-4 4-chloro-1-methylpiperidine 

Downstream Products

• 5382-26-3 1-Aethyl-4-chlor-piperidin 
• 1158961-45-5 C₂₀H₃₁ClN₂O 
• 1392138-87-2 C₂₅H₂₈ClNO₄ 
• 1431735-60-2 2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-4-(4-chloropiperidin-1-yl)phthalazin-1(2H)-one 
• 1613627-45-4 4-(4-chloropiperidin-1-yl)benzonitrile 
• 1613627-81-8 7-chloro-N-[4-(4-chloropiperidin-1-yl)benzyl]-2-ethylimidazo[1,2-a]pyridine-3-carboxamide 
• 1613627-65-8 C₁₂H₁₇ClN₂ 

Relevant articles and documents

Synthesis of 1-tert-butyl-4-chloropiperidine: Generation of an N-tert-butyl group by the reaction of a dimethyliminium salt with methylmagnesium chloride

(Chemical Equation Presented) Two efficient routes to 1-tert-butyl-4- chloropiperidine are described. In the first route, the key thionyl chloride mediated chlorination reaction features the use of tetrabutyl-ammonium chloride as an additive that effectively suppresses the formation of an elimination-derived side product. In the second route, a novel alternative synthesis of 1-tert-butyl-4-chloropiperidine was developed in which the tertiary butyl group on the nitrogen is efficiently generated through the addition of methylmagnesium chloride to a dimethyliminium salt in 71% overall yield.

Tricyclic compounds

Novel compounds of Formula STR1 are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.