676-58-4Relevant articles and documents
Method for preparing 1, 1 and 1 -trifluoro -2 -methyl -2 - propanol
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Paragraph 0022; 0024; 0026; 0028; 0030; 0032; 0034; 0036; .., (2021/12/07)
The invention discloses a method for preparing 1, 1 and 1 -trifluoro -2 -methyl -2 - propanol. To the method, methyl magnesium halide Grignard reagent is prepared from halogenated methane as a raw material in ether solvents, 1, 1 and 1 - trifluoroacetone are reacted in the presence of a catalyst to obtain 1, 1, 1 -trifluoro -2 -methyl -2 -propanol. The method has the advantages of easily available raw materials, convenience in post-treatment and purification, simplicity in operation, relatively low cost, high yield and the like.
Chromium(II)-Catalyzed Diastereoselective and Chemoselective Csp2-Csp3 Cross-Couplings Using Organomagnesium Reagents
Li, Jie,Ren, Qianyi,Cheng, Xinyi,Karaghiosoff, Konstantin,Knochel, Paul
supporting information, p. 18127 - 18135 (2019/11/19)
A simple protocol for performing chromium-catalyzed highly diastereoselective alkylations of arylmagnesium halides with cyclohexyl iodides at ambient temperature has been developed. Furthermore, this ligand-free CrCl2 enables efficient electrophilic alkenylations of primary, secondary, and tetiary alkylmagnesium halides with readily available alkenyl acetates. Moreover, this chemoselective C-C coupling reaction with stereodefined alkenyl acetates proceeds in a stereoretentive fashion. A wide range of functional groups on alkyl iodides and alkenyl acetates are well tolerated, thus furnishing functionalized Csp2-Csp3 coupling products in good yields and high diastereoselectivity. Detailed mechanistic studies suggest that the in situ generated low-valent chromium(I) species might be the active catalyst for these Csp2-Csp3 cross-couplings.
ACID-LABILE ESTER MONOMER HAVING SPIROCYCLIC STRUCTURE, POLYMER, RESIST COMPOSITION, AND PATTERNING PROCESS
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, (2010/12/29)
An acid-labile ester monomer of spirocyclic structure has formula (1) wherein Z is a monovalent group having a polymerizable double bond, X is a divalent group which forms a cyclopentane, cyclohexane or norbornane ring, R2 is H or monovalent hydrocarbon, R3 and R4 are H or monovalent hydrocarbon, or R3 and R4, taken together, stand for a divalent group which forms a cyclopentane or cyclohexane ring, and n is 1 or 2. A polymer obtained from the acid-labile ester monomer has so high reactivity in acid-catalyzed elimination reaction that the polymer may be used to formulate a resist composition having high resolution.
Process for making α,β-unsaturated carboxylic acids
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, (2008/06/13)
α, β-Unsaturated acids of the formula STR1 wherein R1 signifies C1 -C5 -alkyl and Ar signifies an aryl group which is optionally substituted by one or more substituents selected from the group consisting of halogen, phenyl, C1 -C5 -alkyl, C1 -C5 -alkoxy, perfluorinated C1 -C5 -alkyl or perfluorinated C1 -C5 -alkoxy can be obtained from new or known compounds of the formula STR2 Compounds I can be converted by asymmetric hydrogenation into corresponding optically active saturated acids.
Chemical synthesis
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, (2008/06/13)
A process for the production of disubstituted bile acid analogs, including the disubstituted analogs of such bile acids as, lithocholic, hyodeoxycholic, cholic, chenodeoxycholic and ursodeoxycholic acids. This invention was made in the course of work performed under a grant from the U.S. National Heart Lung and Blood Institute.
A HIGHLY EFFICIENT SYNTHETIC ROUTE TO KETONES THROUGH SEQUENTIAL COUPLING REACTIONS OF GRIGNARD REAGENTS WITH S-PHENYL CARBONOCHLORODITHIOATE IN THE PRESENCE OF NICKEL OR IRON CATALYSTS
Cardellicchio, C.,Fiandanese, V.,Marchese, G.,Ronzini, L.
, p. 3595 - 3598 (2007/10/02)
The sequential coupling reactions of Grignard reagents with S-phenyl carbonochloridothioate in the presence of nickel(II) or iron(III) catalysts provides a very mild and straightforward route to symmetrical and unsymmetrical aliphatic and aromatic ketones.
IRON CATALYZED CROSS-COUPLING REACTIONS OF ACYL CHLORIDES WITH GRIGNARD REAGENTS. A MILD, GENERAL, AND CONVENIENT SYNTHESIS OF ALIPHATIC AND AROMATIC KETONES.
Fiandanese, V.,Marchese, G.,Martina, V.,Ronzini, L.
, p. 4805 - 4808 (2007/10/02)
Acyl chlorides couple with Grignard reagents at room temperature in the presence of catalytic amounts of tris(acetylacetonate)iron(III), Fe(acac)3.The reaction is general with respect to both reactants and provides a very mild and convenient method for the synthesis of aliphatic and aromatic ketones.
Infrared Matrix Isolation Study of Magnesium Metal Atom Reactions. Spectra of an Unsolvated Grignard Species
Ault, Bruce S.
, p. 3480 - 3484 (2007/10/02)
Reactions of magnesium atoms with methyl halides in argon matrices have given rise to four product bands which can be assigned to a new chemical species, at 543, 1305, 2800, and 2892 cm-1.All four are hydrogenic in nature, and are assigned to the four vibrations of a C3v methyl group in the reaction product.Evidence is presented for insertion of the magnesium atom into the carbon-halogen bond of the methyl halide to form a species H3CMgX, for X = Cl, Br, I.Similar reactions were observed with calcium and strontium atoms, while zinc atoms did not react with methylhalides under these conditions.No evidence was detected for a strong polar covalent carbon-magnesium bond, suggesting that the unsolvated Grignard reagent formed here has a structure other than that of the solvated solution species.
