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5407-51-2

5407-51-2

Identification

Synonyms:Benzothiazole,2,6-diamino- (6CI,7CI,8CI); 2,6-Diaminobenzothiazole; NSC 5436

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Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:TRC
  • Product Description:1,3-Benzothiazole-2,6-diamine
  • Packaging:500mg
  • Price:$ 175
  • Delivery:In stock
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  • Product Description:1,3-Benzothiazole-2,6-diamine
  • Packaging:250mg
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Benzothiazole-2,6-diamine
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Relevant articles and documentsAll total 20 Articles be found

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity

Fois, Benedetta,Skok, ?iga,Toma?i?, Tihomir,Ila?, Janez,Zidar, Nace,Zega, Anamarija,Peterlin Ma?i?, Lucija,Szili, Petra,Draskovits, Gábor,Nyerges, ákos,Pál, Csaba,Kikelj, Danijel

, p. 265 - 269 (2020)

The emergence of multidrug-resistant bacteria is a global health threat necessitating the discovery of new antibacterials and novel strategies for fighting bacterial infections. We report first-in-class DNA gyrase B (GyrB) inhibitor/ciprofloxacin hybrids that display antibacterial activity against Escherichia coli. Whereas DNA gyrase ATPase inhibition experiments, DNA gyrase supercoiling assays, and in vitro antibacterial assays suggest binding of the hybrids to the E. coli GyrA and GyrB subunits, an interaction with the GyrA fluoroquinolone-binding site seems to be solely responsible for their antibacterial activity. Our results provide a foundation for a new concept of facilitating entry of nonpermeating GyrB inhibitors into bacteria by conjugation with ciprofloxacin, a highly permeable GyrA inhibitor. A hybrid molecule containing GyrA and GyrB inhibitor parts entering the bacterial cell would then elicit a strong antibacterial effect by inhibition of both the GyrA and GyrB subunits of DNA gyrase and potentially slow bacterial resistance development.

Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications

Zhao, Lixing,Hu, Chenyang,Cong, Xuefeng,Deng, Gongda,Liu, Liu Leo,Luo, Meiming,Zeng, Xiaoming

supporting information, p. 1618 - 1629 (2021/01/25)

Transition metal catalysis that utilizes N-heterocyclic carbenes as noninnocent ligands in promoting transformations has not been well studied. We report here a cyclic (alkyl)(amino)carbene (CAAC) ligand-promoted nitro deoxygenative hydroboration with cost-effective chromium catalysis. Using 1 mol % of CAAC-Cr precatalyst, the addition of HBpin to nitro scaffolds leads to deoxygenation, allowing for the retention of various reducible functionalities and the compatibility of sensitive groups toward hydroboration, thereby providing a mild, chemoselective, and facile strategy to form anilines, as well as heteroaryl and aliphatic amine derivatives, with broad scope and particularly high turnover numbers (up to 1.8 × 106). Mechanistic studies, based on theoretical calculations, indicate that the CAAC ligand plays an important role in promoting polarity reversal of hydride of HBpin; it serves as an H-shuttle to facilitate deoxygenative hydroboration. The preparation of several commercially available pharmaceuticals by means of this strategy highlights its potential application in medicinal chemistry.

Trinuclear {Co2+-M3+-Co2+} complexes catalyze reduction of nitro compounds

Srivastava, Sumit,Dagur, Manvender S.,Ali, Afsar,Gupta, Rajeev

, p. 17453 - 17461 (2015/10/19)

This work presents synthesis and characterization of trinuclear {Co2+-Co3+-Co2+} and {Co2+-Fe3+-Co2+} complexes with accessible peripheral Co(ii) ions. Both trinuclear complexes function as efficient reusable heterogeneous catalysts for the selective reduction of assorted nitro compounds to the corresponding amines. The mechanistic investigations suggest the involvement of a Co(ii)-Co(i) cycle in the catalysis.

Process route upstream and downstream products

Process route

2-amino-6-nitrobenzothiazole
6285-57-0

2-amino-6-nitrobenzothiazole

benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; under 1125.11 Torr;
99%
With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere;
98%
With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2.5h; under 2250.23 Torr;
96%
With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 6h; under 1575.16 Torr;
96%
nickel; In tetrahydrofuran; methanol; at 20 ℃;
94%
With hydrogen; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; for 30h; under 2740.9 Torr;
51%
With ethanol; tin(ll) chloride; for 1h; Heating / reflux;
50%
With hydrogenchloride; tin;
With hydrogenchloride; tin(ll) chloride;
With hydrogen; palladium on activated charcoal;
With tin(ll) chloride; In ethanol; Heating;
With hydrogenchloride; iron; In ethanol;
With hydrogen; nickel; In tetrahydrofuran; methanol; at 20 ℃;
With iron; acetic acid; In methanol; at 65 ℃; for 4h;
With hydrogenchloride; tin; In tetrahydrofuran; at 50 ℃; for 1h; Inert atmosphere;
With Et4N[Co(N2,N6-di-(pyridin-2-yl)pyridine-2,6-dicarboxamide)2(CoCl2)2]*10H2O; hydrazine hydrate; In ethanol; at 60 ℃; for 6h; Reagent/catalyst; Catalytic behavior; Mechanism; Schlenk technique; Inert atmosphere;
99 %Chromat.
With sodium tetrahydroborate; water; at 0 - 20 ℃; for 8h;
C<sub>7</sub>H<sub>3</sub>N<sub>3</sub>O<sub>4</sub>S

C7H3N3O4S

benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

Conditions
Conditions Yield
With hydrogen; In tetrahydrofuran; water; at 120 ℃; for 18h; under 37503.8 Torr; chemoselective reaction;
92%
2-amino-6-nitrobenzothiazole
6285-57-0

2-amino-6-nitrobenzothiazole

nickel
7440-02-0

nickel

benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

Conditions
Conditions Yield
In tetrahydrofuran;
50%
(4-amino-phenyl)-thiourea
3394-08-9

(4-amino-phenyl)-thiourea

kieselguhr

kieselguhr

pyrographite
7440-44-0

pyrographite

benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

Conditions
Conditions Yield
With ammonium hydroxide; thionyl chloride; In water;
6-acetylamino-2-aminobenzothiazole
22307-44-4

6-acetylamino-2-aminobenzothiazole

benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

Conditions
Conditions Yield
With sulfuric acid;
benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

Conditions
Conditions Yield
4-Aminophenylthioharnstoff, SOCl2;
benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

6-chloro-2-aminobenzothiazole
95-24-9

6-chloro-2-aminobenzothiazole

Conditions
Conditions Yield
With hydrogenchloride; sodium nitrite; anschliessende Einwirkung von heissem wss. CuCl auf das Reaktionsgemisch;
benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile
214470-68-5

7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile

C<sub>21</sub>H<sub>18</sub>ClN<sub>5</sub>O<sub>2</sub>S
947403-51-2

C21H18ClN5O2S

Conditions
Conditions Yield
With pyridine hydrochloride; In isopropyl alcohol; Reflux;
4,6-dichloropyrimidine
1193-21-1

4,6-dichloropyrimidine

benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

1-[6-(6-Chloro-pyrimidin-4-ylamino)-benzothiazol-2-yl]-3-(2-methoxy-5-methyl-phenyl)-urea
895533-26-3

1-[6-(6-Chloro-pyrimidin-4-ylamino)-benzothiazol-2-yl]-3-(2-methoxy-5-methyl-phenyl)-urea

Conditions
Conditions Yield
4,6-dichloropyrimidine; benzothiazole-2,6-diamine; With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 85 ℃; for 3h;
In N,N-dimethyl-formamide; at 85 ℃; for 3h;
85%
benzothiazole-2,6-diamine
5407-51-2

benzothiazole-2,6-diamine

Benzoyl isothiocyanate
532-55-8

Benzoyl isothiocyanate

1-(2-aminobenzothiazol-6-yl)-3-benzoylthiourea
659742-86-6

1-(2-aminobenzothiazol-6-yl)-3-benzoylthiourea

Conditions
Conditions Yield
In tetrahydrofuran; at 20 ℃; for 7h;
97.3%
In tetrahydrofuran;

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