5435-28-9

Basic information

• Product Name: (3,4,5-trimethoxy-2-nitrophenyl)methanol
• CAS NO: 5435-28-9
• Molecular Formula: C₁₀H₁₃NO₆
• Molecular Weight: 243.2133
• Mol File: 5435-28-9.mol

Chemical Properties

• Boiling Point: 418.1°C at 760 mmHg
• Flash Point: 206.7°C
• Density: 1.299g/cm³
• Vapor Pressure: 9.71E-08mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: (3,4,5-trimethoxy-2-nitrophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4,5-trimethoxy-2-nitrophenyl)methanol(5435-28-9)
• EPA Substance Registry System: (3,4,5-trimethoxy-2-nitrophenyl)methanol(5435-28-9)

Safety Data

• Hazardous Substances Data: 5435-28-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
TNNM is utilized as a precursor in the pharmaceutical industry for the synthesis of various drugs and organic compounds. Its unique structure allows it to be a versatile building block in the development of new medicinal agents.
Used in Research and Development:
In the realm of research and development, TNNM serves as a valuable component for the creation of novel molecules. Its properties make it suitable for exploring potential applications in medicine and industry, contributing to the advancement of scientific knowledge.
Used in Antioxidant and Anti-Inflammatory Applications:
Although further studies are required, TNNM may exhibit potential as an antioxidant and anti-inflammatory agent. Its chemical structure suggests it could play a role in combating oxidative stress and inflammation, which are important factors in various diseases and conditions.
Used in Industrial Applications:
Beyond its pharmaceutical and research applications, TNNM may also find use in various industrial processes. Its chemical properties could be harnessed for specific technical applications, although the exact uses would depend on the industry's needs and further research into its practical applications.

Upstream product

• 66907-52-6 3,4,5-trimethoxy-2-nitrobenzoic acid 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 5081-42-5 3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester 

Downstream Products

• 605-94-7 2,3-Dimethoxy-5-methyl-1,4-benzoquinone 
• 22028-15-5 2,3-Dimethoxy-5-(hydroxymethyl)-2,5-cyclohexadiene-1,4-dione 
• 119137-02-9 Anthracen-2-yl-carbamic acid 3,4,5-trimethoxy-2-nitro-benzyl ester 
• 119137-08-5 3,4,5-Trimethoxy-2-nitroso-benzaldehyde 
• 103387-07-1 2-nitro-3,4,5-trimethoxybenzyl bromide 
• 32151-64-7 (E)-N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-(3,4,5-trimethoxy-2-nitro-phenyl)-acrylamide 
• 32042-18-5 2-Nitro-3,4,5-trimethoxy-zimtsaeure 
• 1308881-77-7 1-(4'-methylbenzyl)-5,6,7-trimethoxyindole 
• 1308881-82-4 1-(3'-fluoro-4'-methoxybenzyl)-5,6,7-trimethoxy-1H-indole 
• 1308881-62-0 2-methoxy-5-(5,6,7-trimethoxyindol-1-yl)phenol 
• 132256-98-5 1,2,3-trimethoxy-4-nitro-5-(2-nitrovinyl)benzene 
• 1379535-26-8 1-(3,4,5-trimethoxy-2-nitrophenyl)prop-2-yn-1-ol 
• 1379535-30-4 1-(3,4,5-trimethoxy-2-nitrophenyl)prop-2-yn-1-one 
• 1379535-66-6 (Z)-3-(4-methoxyphenylamino)-1-(3,4,5-trimethoxy-2-nitrophenyl)prop-2-en-1-one 

Relevant articles and documents

Synthesis of photocaged diamines and their application in photoinduced self-assembly

The photochemical cleavage of covalent bonds is an important strategy in protection group chemistry, as well as for the triggering of chemical events posterior to the application of the physicochemical stimulus. Photocages allow the arresting and traceles

(Z)-1-Aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: Synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies

Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-aryl-3-arylamino-2- propen-1-one (10) were synthesized and evaluated for antiproliferative activity in cell-based assay. The most active compound (Z)-1-(2-bromo-3,4,5- trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one (10ae) was tested in 20 tumor cell lines including multidrug resistant phenotype and was found to induce apoptosis in all these cell lines with similar GI50 values. Flow cytometry studies showed that 10ae arrested the cells in G2/M phase of cell cycle. In addition to G2/M block, these compounds caused microtubule stabilization like paclitaxel and induced apoptosis via activation of the caspase family. The observations made in this investigation demonstrate that (Z)-1-Aryl-3-arylamino-2-propen-1-one (10) represents a new class of microtubule-stabilizing agents.

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.

Z-stilbenes derivatives and the pharmaceutical composition thereof

A series of Z-stilbenes derivatives are disclosed, which have the structure as shown by formula 1. In the structure of formula 1, X is hydrogen, NHR, or nitro group, and R is hydrogen. Y and Z is independently hydrogen, halogen, C1-C10 /s

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

A novel series of 2-amino and 2′-aminocombretastatin derivatives were synthesized and evaluated for antitumor activity. Several compounds had excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 11, 20, and 21 with ICsu