132256-98-5

Upstream product

• 40663-31-8 1-(3,4,5-trimethoxyphenyl)-2-nitroethene 
• 5081-42-5 3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester 
• 66907-52-6 3,4,5-trimethoxy-2-nitrobenzoic acid 
• 5435-28-9 (3,4,5-trimethoxy-2-nitrophenyl)methanol 
• 75-52-5 nitromethane 
• 55149-78-5 2-nitro-3,4,5-trimethoxybenzaldehyde 

Downstream Products

• 1308881-77-7 1-(4'-methylbenzyl)-5,6,7-trimethoxyindole 
• 1308881-82-4 1-(3'-fluoro-4'-methoxybenzyl)-5,6,7-trimethoxy-1H-indole 
• 1308881-62-0 2-methoxy-5-(5,6,7-trimethoxyindol-1-yl)phenol 

Relevant academic research and scientific papers

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.