54998-75-3Relevant articles and documents
METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
-
Paragraph 0177, (2021/04/02)
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
4-Methylthio-2-trifluoromethylmethanesulfonanilide and derivatives thereof
-
, (2008/06/13)
2-(Trifluoromethyl)methanesulfonanilides substituted in the para position by methylthio, methylsulfinyl or methylsulfonyl groups and horticulturally acceptable salts thereof and composition containing these compounds are useful herbicides.