55095-22-2

Basic information

• Product Name: 1,1-bis(4-methylphenyl)methanamine
• Synonyms: 1,1-bis(4-methylphenyl)methanamine;4-METHYL-ALPHA-(4-METHYLPHENYL)-BENZENEMETHANAMINE;DI-P-TOLYLMETHANAMINE
• CAS NO: 55095-22-2
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.306
• Mol File: 55095-22-2.mol

Chemical Properties

• Boiling Point: 339.5±11.0 °C(Predicted)
• Appearance: /
• Density: 1.026±0.06 g/cm3(Predicted)
• PKA: 8.74±0.10(Predicted)
• CAS DataBase Reference: 1,1-bis(4-methylphenyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis(4-methylphenyl)methanamine(55095-22-2)
• EPA Substance Registry System: 1,1-bis(4-methylphenyl)methanamine(55095-22-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 55095-22-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,1-bis(4-methylphenyl)methanamine is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Production:
In the dye industry, 1,1-bis(4-methylphenyl)methanamine serves as a raw material for the production of dyes. Its chemical properties make it suitable for creating a range of colorants used in various applications, including textiles, plastics, and printing inks.
Used in Polymer Synthesis:
1,1-bis(4-methylphenyl)methanamine is utilized as a monomer or a building block in the synthesis of polymers. Its incorporation into polymer chains can enhance the material properties, such as stability, durability, and color, making it valuable in the development of specialty polymers for diverse applications.
Used in Specialty Chemicals Production:
1,1-bis(4-methylphenyl)methanamine also finds application in the production of specialty chemicals, where its unique structure and properties can be harnessed to create high-value products for specific industries, such as agriculture, cosmetics, and coatings.
It is crucial to handle 1,1-bis(4-methylphenyl)methanamine with care due to its potential health hazards if not properly managed. Safe handling practices and appropriate safety measures should be implemented to minimize risks during its use in various industrial applications.

Upstream product

• 44398-45-0 N-dichloromethyl-formamidine 
• 13389-70-3 bis(4-methylphenyl)methyl chloride 
• 127568-35-8 N-[bis(4-methylphenyl)methyl]formamide 
• 76085-56-8 N-(dichloromethyl)methanimidamide hydrochloride 
• 108-88-3 toluene 
• 1714-49-4 4,4'-dimethyl-benzophenone oxime 
• 16620-75-0 4,4'-dimethylbenzophenone imine 
• 104-85-8 para-methylbenzonitrile 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 885-77-8 4,4'-dimethylbenzhydrol 
• 25891-29-6 tris(dichloromethyl)amine 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 114583-47-0 benzophenone N,N,N-trimethylhydrazonium iodide 
• 106-38-7 para-bromotoluene 

Downstream Products

• 5267-52-7 N-(di-p-tolylmethyl)acetamide 
• 69790-44-9 Benzaldehyde N-(4,4'-dimethyl)-benzhydrylimine 
• 78817-21-7 Benzil bis(4,4'-dimethylbenzhydrylimine) 
• 78817-22-8 2,3-diphenyl-5,6-di-(4-methylphenyl)pyrazine 
• 205874-88-0 N-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)bis(4-methylphenyl)methanamine 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 4957-14-6 4,4'-dimethyldiphenylmethane 
• 1101850-33-2 (S)-N-{(R)-2-[bis(p-methylphenyl)methylamino]-2-phenylethyl}prolinol 
• 1421837-11-7 N-(di-p-tolylmethyl)-2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)acetamide 
• 1581274-94-3 C₂₂H₂₃NO₂S 
• 205875-00-9 N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)bis(4-methylphenyl)methanamine 

Relevant articles and documents

Electrochemical Oxidative C(sp3)-H/N-H Coupling of Diarylmethanes with Sulfoximines or Benzophenone Imine

Herein, we report an efficient electrochemical method for the synthesis of N-alkylated sulfoximines by electrochemical oxidative C(sp3)-H/N-H coupling of sulfoximines and diarylmethanes. In addition, we used the same conditions for electrochemical dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent. The reactions showed good functional group tolerance and afforded the corresponding products in moderate to good yields without the use of a stoichiometric oxidant, a metal catalyst, or an activating agent.

Chiral isoindoline compound and preparation method thereof

The invention belongs to the field of organic chemicals, and provides a chiral isoindoline compound and a preparation method thereof to solve the problem that an existing synthesized chiral isoindoline compound has strict reaction conditions. The preparat

Palladium-Catalyzed α-Arylation of Aryl Nitromethanes

Catalytic conditions for the α-arylation of aryl nitromethanes have been discovered using parallel microscale experimentation, despite two prior reports of the lack of reactivity of these aryl nitromethane precursors. The method efficiently provides a variety of substituted, isolable diaryl nitromethanes. In addition, it is possible to sequentially append two different aryl groups to nitromethane. Mild oxidation conditions were identified to afford the corresponding benzophenones via the Nef reaction, and reduction conditions were optimized to afford several diaryl methylamines.

Pd-catalyzed enantioselective C-H iodination: Asymmetric synthesis of chiral diarylmethylamines

An enantioselective C-H iodination reaction using a mono-N-benzoyl- protected amino acid has been developed for the synthesis of chiral diarylmethylamines. The reaction uses iodine as the sole oxidant and proceeds at ambient temperature and under air.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-reiated orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

THERAPEUTIC METHODS

The present invention relates to methods of treatment of diseases mediated by ROR?.

Cu(OAc)2-mediated cross-coupling reaction of benzophenone N,N,N-trimethylhydrazonium salts and aryl boronic acids

Cu(OAc)2-mediated coupling of benzophenone N,N,N- trimethylhydrazonium salts and aryl boronic acids proceeded to afford N-aryl imines.

Mapping the active site in a chemzyme: Diversity in the N-substituent in the catalytic asymmetric aziridination of imines

(Chemical Equation Presented) The active site of the aziridination catalyst derived from either the VANOL or VAPOL ligand and B(OPh)3 is larger than expected and can accommodate not only significant substitution on the diarylmethyl unit of the imine but also that alkyl (but not perfluorylalkyl) substituents on the aryl groups lead to enhanced rates and enantioselection. The screen of diarylmethyl N-substituents on the imine revealed that the 3,5-di-tert-butyldianisylmethyl group (BUDAM) gave exceptionally high asymmetric inductions for imines of aryl aldehydes.

Orthoamides, LXIV [1]. Formylation of aromatic compounds by tris(dichloromethyl)amine and oligoformylamine derivatives in the presence of superacids

Tris(dichloromethyl)amine (4), triformamide (1) and tris(diformylamino) methane ( formyl-aalen ) (2) can be activated by addition of trifluoromethanesulfonic acid. The formylating systems thus formed transform activated aromatic compounds, such as toluene, anisole or 2,4-dimethoxybenzene to the corresponding aldehydes. The formylating ability of systems from 4 and superacids, such as FSO3H, FSO3H/SbF5, C 4F9SO3H, and mixtures of aluminum chloride with C4F9SO3H and chlorosulfonic acid, respectively, is compared. In general, low reaction temperatures (-20 to -10°C) are necessary to obtain aldehydes with acceptable to good yields. Remarkably, at higher temperatures (～ 100°C) compound 4 can also act as a formylating agent in the presence of suitable zeolites, as e. g. zeolite HBEA. Reaction mechanisms of the new formylation reactions are proposed.

Synthesis of substituted benzhydrylamines

The synthesis of para di- and monosubstituted benzhydrylamines by addition of Grignard reagents to benzonitriles and subsequent reduction, is evaluated and discussed. The reduction step with sodium borohydride allows simple handling and mild conditions. An optimized synthesis of 4,4'-dimethoxybenzhydrylamine by this method is disclosed.