55876-91-0

Basic information

• Product Name: METHYL 5-FORMYLPICOLINATE
• Synonyms: METHYL 5-FORMYLPICOLINATE;ethyl 5-forMylpicolinate;5-ForMyl-pyridine-2-carboxylic acid Methyl ester;methyl 5-formylpyridine-2-carboxylate;2-Pyridinecarboxylic acid, 5-formyl-, methyl ester;5-formyl-2-Pyridinecarboxylic acid methyl ester
• CAS NO: 55876-91-0
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 55876-91-0.mol

Chemical Properties

• Boiling Point: 322.7°C at 760 mmHg
• Flash Point: 148.9°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 0.000275mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.11±0.10(Predicted)
• CAS DataBase Reference: METHYL 5-FORMYLPICOLINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-FORMYLPICOLINATE(55876-91-0)
• EPA Substance Registry System: METHYL 5-FORMYLPICOLINATE(55876-91-0)

Safety Data

• Hazardous Substances Data: 55876-91-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-formylpicolinate is used as a building block in organic synthesis for the development of potential drug candidates. Its unique chemical properties and structural features contribute to the creation of novel compounds with therapeutic potential.
Used in Agrochemicals:
Methyl 5-formylpicolinate is also utilized in the synthesis of various chemical compounds, including those with potential applications in agrochemicals. Its versatility allows for the development of new compounds that can address specific agricultural needs.
Used in Medicinal Chemistry and Drug Discovery:
Due to its diverse chemical properties, Methyl 5-formylpicolinate has potential applications in medicinal chemistry and drug discovery. It can be employed to design and synthesize new molecules with therapeutic effects, contributing to the advancement of pharmaceutical research.
Used in Research and Industrial Purposes:
Methyl 5-formylpicolinate serves as a valuable reagent in the preparation of complex organic molecules for both research and industrial applications. Its ability to form various chemical compounds makes it an essential component in the synthesis of advanced organic molecules.

InChI:InChI=1/C8H7NO3/c1-12-8(11)7-3-2-6(5-10)4-9-7/h2-5H,1H3

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 149806-06-4 6-bromonicotinaldehyde 

Downstream Products

• 138815-50-6 5-<2-(4-chlorophenyl)ethenyl>-2-(methoxycarbonyl)pyridine 
• 138834-58-9 methyl (E)-5-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)picolinate 
• 138834-61-4 2-carboxypyridine-5-propenoic acid 
• 138815-49-3 5-<2-(4-chlorophenyl)ethenyl>pyridine-2-carboxylic acid 
• 1239173-97-7 C₂₁H₁₈F₃N₃O₅ 

Relevant articles and documents

COMPOUNDS AND METHODS OF USE

This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated to modulate the NMDA receptor.

Povarov reaction, scope and limitations: Preparation of diversely heterocyclic tetrahydro-1H-cyclopenta[c]quinolines

Parallel synthesis of diverse heterocyclic-tetrahydro-1H-cyclopenta[c]quinolines in excellent yields and high endo diastereoselectivity has been described hereia These compounds are highly functionalized natural product-like tricyclic systems, which may be useful as biologically relevant targets. Fine tuning of the reaction conditions need to be performed depending on the nature and molecular structure of the heterocyclic aromatic carbaldehyde, as well as the choice of the Lewis acid catalyst. Synthesis of the heterocyclic aromatic aldehyde precursors of the Povarov Reaction is also described.

LSD1 INHIBITORS AND USES THEREOF

Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSDl.

SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS

The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.

DIMERIC PYRROLOPYRIMIDINEDIONE AND ITS USE IN THERAPY OF RESPIRATORY DISEASES

The compound of formula(I)is an inhibitor of human neutrophil elastase,useful for inhalation treatment of pulmonary inflammation