5685-05-2

Basic information

• Product Name: 2-Mercaptothiazole
• Synonyms: 2-Mercapto-1,3-thiazole;2-Thiazolethiol;4-Thiazoline-2-thione;Thiazoline-2-thione;2-Mercaptothiazole;Thiazole-2(3H)-thione;2(3H)-Thiazolethione (9ci);4-Thiazoline-2-thione (8ci)
• CAS NO: 5685-05-2
• Molecular Formula: C₃H₃NS₂
• Molecular Weight: 117.19
• EINECS: 423-680-4
• Product Categories: API intermediates
• Mol File: 5685-05-2.mol

Chemical Properties

• Melting Point: 80 °C(Solv: water (7732-18-5))
• Boiling Point: 194.7 °C at 760 mmHg
• Flash Point: 71.5 °C
• Appearance: /
• Density: 1.47 g/cm³
• Vapor Pressure: 0.437mmHg at 25°C
• Refractive Index: 1.754
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.58±0.20(Predicted)
• CAS DataBase Reference: 2-Mercaptothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Mercaptothiazole(5685-05-2)
• EPA Substance Registry System: 2-Mercaptothiazole(5685-05-2)

Safety Data

• Statements: R20/22:
• Safety Statements: S22;S36/37:
• Hazardous Substances Data: 5685-05-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Mercaptothiazole is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its unique chemical properties to contribute to the development of new drugs.
Used in Pesticide Industry:
In the pesticide industry, 2-Mercaptothiazole is utilized as an intermediate in the production of different types of pesticides, enhancing their effectiveness in controlling pests.
Used in Petroleum Industry:
2-Mercaptothiazole is employed as a corrosion inhibitor in the petroleum industry, where it plays a crucial role in preventing the corrosion of metal surfaces, thereby extending the lifespan of equipment and infrastructure.
Used in Pharmaceutical Research:
Due to its potential anti-fungal and anti-bacterial properties, 2-Mercaptothiazole is studied for its applications in pharmaceutical research, offering a promising avenue for the development of new treatments and therapies.

InChI:InChI=1/C3H3NS2/c5-3-4-1-2-6-3/h1-2H,(H,4,5)

Upstream product

• 107-20-0 2-chloroethanal 
• 513-74-6 ammonium dithiocarbamate 
• 17157-48-1 bromoacetaldehyde 
• 64-17-5 ethanol 
• 3034-53-5 2-bromo-1,3-thiazole 

Downstream Products

• 69390-09-6 bis(1,3-thiazol-2-yl) sulfide 
• 69390-08-5 2-Butylmercapto-thiazol 
• 71371-09-0 3-oxo-2-phenyl-2,3-dihydro-thiazolo[2,3-b]thiazolylium betaine 
• 15545-32-1 2-benzylthio-1,3-thiazole 
• 406162-66-1 4-(3-chlorophenyl)-6-[hydroxy(1-methyl-1H-imidazol-5-yl)[4-[(2-thiazolylthio)methyl]phenyl]methyl]-1-methyl-2(1H)-quinolinone 
• 152759-58-5 Cu(P(C₆H₅)3)2(C₃H₃NS₂)I 
• 118613-31-3 2-thiolato thiazoline hydridocarbonylbis(triphenylphosphine)ruthenium(II) 
• 118613-30-2 2-thiolato thiazoline chlorocarbonylbis(triphenylphosphine)ruthenium(II) 
• 97022-93-0 2-Thioxo-3,5-bis--thiazol 
• 90649-05-1 2-Thioxo-3-piperidinomethyl-thiazol 
• 6503-08-8 2-(4-chloro-cis-styrylsulfanyl)-thiazole 
• 6503-10-2 2-(2,4,5-trichloro-cis-styrylsulfanyl)-thiazole 
• 91088-95-8 3-(2-methyl-anilinomethyl)-3H-thiazole-2-thione 
• 91088-94-7 3-(N-methyl-anilinomethyl)-3H-thiazole-2-thione 

Relevant articles and documents

Thiazole derivatives and application thereof in agriculture

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5 - Hydroxy indoles containing heterocyclic ring derivative and its use

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Compounds containing a N-heteroaryl moiety linked to fused ring moieties for the inhibition of NAD(P)H oxidases and platelet activation

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Thiazolo[4,5-d]pyrimidines and pyridines as corticotropin releasing factor (CRF) antagonists

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Cephalosporin compounds and antibacterial agents

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A DIRECT SYNTHESIS OF HETEROCYCLIC THIOLS

Heterocyclic thiols (thiones) are conveniently synthesized in good yields by the reaction of heterocyclic halides with sodium thiosulfate.The reaction requires the presence of acid, either added or liberated during the reaction, to hydrolyze the intermediate thiosulfate to thiol.

Cephalosporin displacement reaction

The present invention is directed to a process for the displacement of the acetoxy group of a cephalosporanic acid by a sulfur nucleophile, in an organic solvent and under essentially anhydrous conditions.