57519-09-2

Basic information

• Product Name: N'-Methyl-L-histidine methyl ester
• Synonyms: H-His(Nim-Me)-OMe;N'-Methyl-L-histidine methyl ester;H-His(Nτ-Me)-OMe·HCl;H-His(Nt-Me)-OMeCl;(S)-methyl 2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoate hydrochloride;N-tau-Methyl-L-histidine methyl ester hydrochloride;N-Im-1-Methyl-L-Histidine Methyl Ester Hcl;H-His(1-Me)-Ome Hydrochloride salt
• CAS NO: 57519-09-2
• Molecular Formula: C8H13N3O2
• Molecular Weight: 183.21
• Product Categories: Amino hydrochloride;Histidine [His, H];Amino Acids and Derivatives
• Mol File: 57519-09-2.mol

Chemical Properties

• Boiling Point: 347.2 °C at 760 mmHg
• Flash Point: 163.8 °C
• Appearance: /
• Density: 1.24
• Vapor Pressure: 5.48E-05mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• Solubility: Dichloromethane; Ethyl Acetate; Methanol; Ethanol
• PKA: 6.62±0.10(Predicted)
• CAS DataBase Reference: N'-Methyl-L-histidine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N'-Methyl-L-histidine methyl ester(57519-09-2)
• EPA Substance Registry System: N'-Methyl-L-histidine methyl ester(57519-09-2)

Safety Data

• Hazardous Substances Data: 57519-09-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N'-Methyl-L-histidine methyl ester is used as an intermediate for the synthesis of L-Balenine Hydrochloride (B115520). L-Balenine is an imidazole dipeptide that has been found in the dorsal muscle and amino acid composition in body parts of whales. N'-Methyl-L-histidine methyl ester plays a significant role in the development of pharmaceuticals targeting specific health conditions.
Used in Research and Development:
N'-Methyl-L-histidine methyl ester is also utilized in research and development for the study of its chemical properties and potential applications in the creation of new drugs and therapies. Its unique structure and properties make it a valuable compound for exploring novel pharmaceutical solutions.

InChI:InChI=1/C8H13N3O2/c1-11-4-6(10-5-11)3-7(9)8(12)13-2/h4-5,7H,3,9H2,1-2H3/t7-/m0/s1

Upstream product

• 109-72-8 n-butyllithium 
• 332-80-9 His(1-CH₃) 
• 890306-83-9 (S)-methyl 2-(benzyloxycarbonylamino)-3-(1-methyl-1H-imidazol-4-yl)propanoate 
• 17289-26-8 1-methyl-1H-imidazole-4-carbaldehyde 
• 72212-49-8 N^α-(tertbutoxycarbonyl)-N^τ-methyl-L-histidinate 
• 7389-87-9 L-histidine methyl ester dihydrochloride 
• 69614-04-6 S-(+)-7-Methoxycarbonyl-5,6,7,8-tetrahydroimidazo<1,5-c>pyrimidin-5-on 

Downstream Products

• 331-38-4 L-anserine 

Relevant articles and documents

Preparation method of N(pi)-methyl-L-histidine derivative and application thereof to synthesis of whale carnosine

The invention relates to a preparation method of an N(pi)-methyl-L-histidine derivative and a method for preparing anserine from the synthesized N(pi)-methyl-L-histidine derivative. By the preparationmethod, raw materials are cheap and easy to obtain, the selectivity is good and the yield is high; the operation is simple and easy to implement, a technology is stable, the control is easy, treatment after a reaction is convenient, the product yield is good, the purity is high, and the preparation method can be economically and conveniently applied to industrial production.

Concise Synthesis of Anserine: Efficient Solvent Tuning in Asymmetric Hydrogenation Reaction

A concise synthesis of anserine and related compounds was accomplished by Et-DuPhos-Rh-catalyzed asymmetric hydrogenation of dehydrohistidine derivatives in 2,2,2-trifluoroethanol, which played a key role in improving the yield and selectivity.

Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues

We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. Copyright