5835-26-7 Usage
Description
Isopimaric acid is a terpenoid acid that exhibits a range of biological activities, including the activation of BK (voltage-gated potassium) channels, improvement of spatial and non-spatial memory in Alzheimer's mouse models, and enhancement of motor function in rat spinal cord injury models. It also reduces hyperactivity of spontaneously active auditory networks.
Uses
Used in Pharmaceutical Industry:
Isopimaric acid is used as a potent novel activator of large-conductance Ca2+-activated K+ channels for its potential therapeutic applications in various conditions, such as Alzheimer's disease and spinal cord injuries. Its ability to improve memory and motor function, as well as reduce hyperactivity in auditory networks, makes it a promising candidate for further research and development in the pharmaceutical field.
Biochem/physiol Actions
Potent opener of large conductance calcium activated K+ (BK) channels.
References
Imaizumi et al. (2002), Molecular basis of pimarane compounds as novel activators of large-conductance CA(2+)-activated K(+) channel alpha-subunit; Mol. Pharmacol., 62 836
Wang et al. (2015), Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer’s disease; Neuropharmacology, 92 8
Wang et al. (2015), Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer’s disease model mice; Neuropharmacology, 97 210
Jacobsen et al. (2018), Activation of the Large-conductance, Voltage, and Ca2+-Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat is Neuroprotective; Front. Neurol., 9 1107
Wu et al. (2014), Pharmacodynamics of potassium channel openers in cultured neuronal networks; Eur. J. Pharmacol., 732 68
Check Digit Verification of cas no
The CAS Registry Mumber 5835-26-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,3 and 5 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5835-26:
(6*5)+(5*8)+(4*3)+(3*5)+(2*2)+(1*6)=107
107 % 10 = 7
So 5835-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,7,15-16H,1,6,8-13H2,2-4H3,(H,21,22)/t15?,16?,18-,19+,20+/m0/s1