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616867-28-8

616867-28-8

Identification

Synonyms:(R)-N-FMOC-alpha-Methylvaline, 98% ee, 98%;(R)-N-FMOC-alpha-Methylvaline, 98%, 98% ee;FMoc-(R)-2-aMino-2,3-diMethylbutanoic acid;(R)-N-FMOC-alpha-Methylvaline;FMoc-α-Me-D-Val-OH;Fmoc-α-methyl-D-Valine;(R)-N-Fmoc-a-Methylvaline;Fmoc-alpha-Me-D-Val-OH

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
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  • Purchase
  • Manufacture/Brand:Crysdot
  • Product Description:(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoicacid 95+%
  • Packaging:1g
  • Price:$ 465
  • Delivery:In stock
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  • Manufacture/Brand:ChemSupplyAustralia
  • Product Description:(R)-N-Fmoc-α-Methylvaline, 98%
  • Packaging:100 mg
  • Price:$ 74.8
  • Delivery:In stock
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  • Manufacture/Brand:ChemSupplyAustralia
  • Product Description:(R)-N-Fmoc-α-Methylvaline, 98%
  • Packaging:1 g
  • Price:$ 440
  • Delivery:In stock
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  • Manufacture/Brand:ChemSupplyAustralia
  • Product Description:(R)-N-Fmoc-α-Methylvaline, 98%
  • Packaging:5 g
  • Price:$ 1320
  • Delivery:In stock
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  • Manufacture/Brand:ChemPep
  • Product Description:Fmoc-α-Me-D-Val-OH
  • Packaging:5g
  • Price:$ 1400
  • Delivery:In stock
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  • Manufacture/Brand:ChemPep
  • Product Description:Fmoc-α-Me-D-Val-OH
  • Packaging:1g
  • Price:$ 500
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoicacid 95%
  • Packaging:1g
  • Price:$ 439
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:(R)-N-FMOC-A-METHYLVALINE 95.00%
  • Packaging:5MG
  • Price:$ 451.42
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoicacid 95+%
  • Packaging:1g
  • Price:$ 517
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoicacid 95+%
  • Packaging:250mg
  • Price:$ 517
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Relevant articles and documentsAll total 2 Articles be found

A stereodivergent approach to chiral nonracemic N-protected α,α-dialkylated amino acids

Spino, Claude,Gobdout, Cedrickx

, p. 12106 - 12107 (2007/10/03)

Menthyl carboxaldehyde is used as a chiral auxiliary to make quaternary amino acids of either configuration via a stereodivergent approach that includes an SN2′ displacement by a cuprate reagent and a Curtius rearrangement as key steps. Copyright

Process route upstream and downstream products

Process route

(R)-2-amino-2,3-dimethylbutanoic acid
53940-82-2

(R)-2-amino-2,3-dimethylbutanoic acid

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

(R)-N<sup>2</sup>-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline
616867-28-8

(R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline

Conditions
Conditions Yield
With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; Multistep reaction; 1.) CH2Cl2, 60 deg C, 1 h, 2.) CH2Cl2, 50 deg C, 2 h;
(1-hydroxymethyl-1,2-dimethyl-propyl)-carbamic acid 9<i>H</i>-fluoren-9-ylmethyl ester
616867-27-7

(1-hydroxymethyl-1,2-dimethyl-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

(R)-N<sup>2</sup>-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline
616867-28-8

(R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline

Conditions
Conditions Yield
With jones reagent; In acetone; at 20 ℃; for 3h;
83%
9-Fluorenylmethanol
24324-17-2

9-Fluorenylmethanol

(R)-N<sup>2</sup>-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline
616867-28-8

(R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 676 mg / 110 °C
2: 100 percent / HF*pyridine / tetrahydrofuran / 6 h / 20 °C
3: 83 percent / Jones reagent / acetone / 3 h / 20 °C
With jones reagent; pyridine hydrogenfluoride; In tetrahydrofuran; acetone;
<i>tert</i>-butyl-(2-isocyanato-2,3-dimethyl-butoxy)-diphenyl-silane

tert-butyl-(2-isocyanato-2,3-dimethyl-butoxy)-diphenyl-silane

(R)-N<sup>2</sup>-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline
616867-28-8

(R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 676 mg / 110 °C
2: 100 percent / HF*pyridine / tetrahydrofuran / 6 h / 20 °C
3: 83 percent / Jones reagent / acetone / 3 h / 20 °C
With jones reagent; pyridine hydrogenfluoride; In tetrahydrofuran; acetone;
2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-2,3-dimethyl-butyric acid
616867-25-5

2-(tert-butyl-diphenyl-silanyloxymethyl)-2,3-dimethyl-butyric acid

(R)-N<sup>2</sup>-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline
616867-28-8

(R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: Et3N; diphenylphosphoryl azide / toluene / 2 h / Heating
2: 676 mg / 110 °C
3: 100 percent / HF*pyridine / tetrahydrofuran / 6 h / 20 °C
4: 83 percent / Jones reagent / acetone / 3 h / 20 °C
With jones reagent; diphenylphosphoranyl azide; pyridine hydrogenfluoride; triethylamine; In tetrahydrofuran; acetone; toluene; 1: Curtius rearrangement;
[1-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-1,2-dimethyl-propyl]-carbamic acid 9<i>H</i>-fluoren-9-ylmethyl ester

[1-(tert-butyl-diphenyl-silanyloxymethyl)-1,2-dimethyl-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

(R)-N<sup>2</sup>-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline
616867-28-8

(R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 100 percent / HF*pyridine / tetrahydrofuran / 6 h / 20 °C
2: 83 percent / Jones reagent / acetone / 3 h / 20 °C
With jones reagent; pyridine hydrogenfluoride; In tetrahydrofuran; acetone;
methyl (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-amino-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoate
669074-47-9

methyl (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-amino-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoate

(R)-N<sup>2</sup>-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline
616867-28-8

(R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline

3-methyl-D-isovalyl-N-{(1S,2R)-4-{(2S)-2-[(1R,2R)-3-{[(1S)-1-benzyl-2-methoxy-2-oxoethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl}-N-methyl-L-valinamide

3-methyl-D-isovalyl-N-{(1S,2R)-4-{(2S)-2-[(1R,2R)-3-{[(1S)-1-benzyl-2-methoxy-2-oxoethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl}-N-methyl-L-valinamide

Conditions
Conditions Yield
methyl (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-amino-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoate; (R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 12h;
With diethylamine; In tetrahydrofuran; for 12h;
69%

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