616867-28-8 Usage
Uses
Used in Pharmaceutical Industry:
(R)-N-FMOC-alpha-Methylvaline, 98% ee, 98% is used as a building block for the synthesis of complex peptide-based drug molecules. Its high purity and enantiomeric excess ensure the quality and consistency of the synthesized compounds, which is crucial for drug development and efficacy.
Used in Biotechnology Industry:
In the biotechnology field, (R)-N-FMOC-alpha-Methylvaline, 98% ee, 98% is utilized as a component in the study of protein function and structure. Its incorporation into peptides and peptidomimetics allows researchers to investigate the role of specific amino acid sequences in protein-protein interactions and other biological processes.
Used in Organic Chemistry Research:
(R)-N-FMOC-alpha-Methylvaline, 98% ee, 98% serves as a valuable reagent in organic chemistry research, particularly in the development of novel synthetic methods and the exploration of new chemical reactions. Its high purity and enantiomeric excess facilitate the synthesis of enantiomerically pure compounds, which are essential for understanding the stereochemistry of chemical reactions and the biological activity of chiral molecules.
Used in Drug Discovery:
(R)-N-FMOC-alpha-Methylvaline, 98% ee, 98% is employed in drug discovery as a key component in the design and synthesis of potential therapeutic agents. Its unique structural features and high purity make it an attractive candidate for the development of new drugs with improved pharmacological properties and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 616867-28-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,6,8,6 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 616867-28:
(8*6)+(7*1)+(6*6)+(5*8)+(4*6)+(3*7)+(2*2)+(1*8)=188
188 % 10 = 8
So 616867-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H23NO4/c1-13(2)21(3,19(23)24)22-20(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18H,12H2,1-3H3,(H,22,25)(H,23,24)/t21-/m1/s1
616867-28-8Relevant articles and documents
A stereodivergent approach to chiral nonracemic N-protected α,α-dialkylated amino acids
Spino, Claude,Gobdout, Cedrickx
, p. 12106 - 12107 (2007/10/03)
Menthyl carboxaldehyde is used as a chiral auxiliary to make quaternary amino acids of either configuration via a stereodivergent approach that includes an SN2′ displacement by a cuprate reagent and a Curtius rearrangement as key steps. Copyright
L-phenylalanine cyclohexylamide: A simple and convenient auxiliary for the synthesis of optically pure α,α-disubstituted (R)- and (S)-amino acids
Obrecht,Bohdal,Broger,Bur,Lehmann,Ruffieux,Schonholzer,Spiegler,Muller
, p. 563 - 580 (2007/10/02)
This work describes L-phenylalanine cyclohexylamide (5c) as a simple, cheap, and powerful chiral auxiliary for the synthesis of a series of optically pure α,α-disubstituted (R)- and (S)-amino acids of type 1, such as (R)- and (S)-2-methyl-phenylalanine (1a), (R)- and (S)-2-methyl-2-phenylglycine (1b), and (R)- and (S)-2-methylvaline (1c). These amino acids were efficiently transformed into the suitably protected and activated amino-acid building blocks (R)- and (S)-12b and (R)- and (S)-12c which are ready for incorporation into peptides by solution or solid-phase techniques. Based on the crystal structures of 6b, 6c, and 7a belonging to the diastereoisomeric peptides series 6 and 7, the absolute configurations of each member of the series were determined. β-Turn geometries of type II' and I were observed for 6b and 7a, respectively, whereas 6c crystallized in an extended conformation. The impacts of side-chain variation on conformation and crystal packing of these triamides are discussed.
