61781-58-6

Basic information

• Product Name: L-Phenylalanine, N-acetyl-, cyanomethyl ester
• CAS NO: 61781-58-6
• Molecular Formula: C13H14N2O3
• Molecular Weight: 246.266
• Mol File: 61781-58-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-acetyl-, cyanomethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-acetyl-, cyanomethyl ester(61781-58-6)
• EPA Substance Registry System: L-Phenylalanine, N-acetyl-, cyanomethyl ester(61781-58-6)

Safety Data

• Hazardous Substances Data: 61781-58-6(Hazardous Substances Data)

Upstream product

• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 590-17-0 cyanomethyl bromide 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 1130858-12-6 2-amino-2-thioxoethyl N-acetyl-L-phenylalaninate 
• 34996-32-2 (S)-(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl 2-acetamido-3-phenylpropanoate 
• 60397-86-6 N-acetyl-L-phenylalanine carbamoylmethyl ester 

Relevant articles and documents

Homoserine and Threonine Peptide Assembly

Drawing on our recent success with reagent-less peptide-bond formation through serine-based assembly reactions in organic solvent, their range has been expanded to threonine and homoserine (an aspartic acid precursor) in the N -terminal peptide. Amino aci

Native Serine Peptide Assembly – Scope and Utility

This work develops serine peptide assembly (SPA), which complements and contrasts with classic native chemical ligation (NCL). Advances in reagentless peptide-bond formation have been applied to serine (and serine models) and a range of C-terminal amino acids, including bulky residues that are not amenable to NCL. The particular appeal of SPA is preparative-scale segment condensations with zero racemization risk and favorable process mass intensity (PMI). Mechanistic studies support a previously proposed reaction pathway via an initial transesterification step. An understanding of the factors favoring this pathway relies on hard–soft acid–base theory, according to which mildly activated esters with the largest carbonyl positive charge are most reactive with hydroxyamines. Novel C-terminal activators have been discovered that enhance reactivity and give harmless byproducts.

The BF3·OEt2-assisted conversion of nitriles into thioamides with Lawesson's reagent

A method for the thiolysis of nitriles by applying Lawesson's reagent and facilitated by the addition of boron trifluoride-diethyl ether complex is reported. The method opens an easy access to primary thioamides. Aromatic, benzylic, and aliphatic nitriles were converted into the corresponding thioamides in high to quantitative yields (even in unfavorable cases, e.g., ortho-substitut-ed benzonitriles). The reaction was performed in 1,2-dimethoxyethane-tetrahydrofuran or toluene-diethyl ether solvent mixtures at 20-50°C, and exhibited considerable selectivity in the case of multifunctional nitrile substrates, such as cyanomethyl N-acetylphenylalaninate, benzoylacetonitrile, 4-cyanobenzamide, 4-acetylbenzonitrile, or pent-3-enenitrile. Georg Thieme Verlag Stuttgart.