6205-08-9

Basic information

• Product Name: N-ALPHA-ACETYL-L-ORNITHINE
• Synonyms: AC-ORNITHINE;AC-ORN-OH;AC-OM-OH;ACETYL-L-ORNITHINE;N-ACETYL-L-ORN;N-ALPHA-ACETYL-L-ORNITHINE;N-A-acetyl-L-ornithine crystalline;nα-acetyl-l-ornithine
• CAS NO: 6205-08-9
• Molecular Formula: C₇H₁₄N₂O₃
• Molecular Weight: 174.2
• Product Categories: A - H;Amino Acids;Modified Amino Acids
• Mol File: 6205-08-9.mol

Chemical Properties

• Boiling Point: 436.2°C at 760 mmHg
• Flash Point: 217.6°C
• Appearance: /Solid
• Density: 1.171g/cm³
• Vapor Pressure: 7.87E-09mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: −20°C
• Solubility: Aqueous Acid (Sparingly, Sonicated), Aqueous Base (Sparingly), Water (Sparingly)
• PKA: 3.41±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: N-ALPHA-ACETYL-L-ORNITHINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ALPHA-ACETYL-L-ORNITHINE(6205-08-9)
• EPA Substance Registry System: N-ALPHA-ACETYL-L-ORNITHINE(6205-08-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 6205-08-9(Hazardous Substances Data)

Usage

Uses

Used in Medical Research:
N-ALPHA-ACETYL-L-ORNITHINE is used as a biomarker for the identification of type 2 diabetes group through topological analysis of patient similarity. This application aids in the diagnosis and understanding of the disease's progression, potentially leading to more effective treatments and interventions.

Biochem/physiol Actions

Nα-Acetyl-L-ornithine (AORN) is a substrate for the identification, differentiation and characterization of N(α)-acetyl-L-ornithine deacetylase(s) and of N-Acetyl-l-ornithine transcarbamylase(s) (AOTCase) found in plants, some eubacteria and some human pathogens.

InChI:InChI=1/C7H14N2O3/c1-5(10)9-6(7(11)12)3-2-4-8/h6H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t6-/m0/s1

Upstream product

• 3304-51-6 N-carboxybenzyl-L-ornithine 
• 108-24-7 acetic anhydride 
• 70-26-8 L-ornithine 
• 35515-72-1 N-acetyl-N^δ-benzyloxycarbonyl-L-ornithine 
• 16937-91-0 N^ε-(benzyloxycarbonyl)ornithine 

Downstream Products

• 70-26-8 L-ornithine 
• 25693-39-4 N^δ-(R,S-2-amino-2-carboxyethyl)-S-ornithine 
• 13074-21-0 N-acetyl-L-glutamate 5-semialdehyde 

Relevant articles and documents

Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid

The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

Inhibitors of N α-acetyl-l-ornithine deacetylase: Synthesis, characterization and analysis of their inhibitory potency

A series of N α-acyl (alkyl)- and N α- alkoxycarbonyl-derivatives of l- and d-ornithine were prepared, characterized, and analyzed for their potency toward the bacterial enzyme N α-acetyl-l-ornithine deacetylase (ArgE). Ar

IsN-acetylornithine aminotransferase the real N-succinyl-LL-diaminopimelate aminotransferase in Escherichia coli and Mycobacterium smegmatis?

We examined the similarities and differences between the activities of N-succinyl-LL-diaminopimelate aminotransferase (DAP-AT) and N-acetylornithine aminotransferase (NAcO-AT) from E. coli and M. smegmatis in order to investigate recent claims that the tw

Cosmetic composition

A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamine derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

Cosmetic composition containing DOPA derivatives

A composition for topical application to human hair or skin contains a chemical analogue of dihydroxyphenyl alanine (DOPA). This chemical analogue can be absorbed by skin or by a hair follicle and metabolised in-vivo, thus leading to the formation of melanin in skin or to the growth of melanin-pigmented hair. Consequently the composition can give controlled skin darkening to mimic sun-induced tanning or can bring about the growth of dar hair in place of the grey or white hair.

Cosmestic composition

A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamic acid derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

Hair growth composition containing citric acid esters

Triesters of citric acid are used for inducing, maintaining or increasing hair growth. Compositions for topical application to mammalian hair or scalp comprise an effective amount of from 1% to 99% by weight of an ester of citric acid having the structure (1): where, R1, R2 and R3 each independently represent a branched or unbranched alkyl, alkenyl, aryl, alkylaryl or arylalkyl group, each said group having from 1 to 18 carbon atoms, R4 represents -H, or a branched or unbranched saturated or unsaturated acyl, alkyl, aryl, alkylaryl or aylalkyl group having from 1 to 18 carbon atoms, in the presence of a cosmetically acceptable vehicle for the citric acid ester and in the absence of solid absorbent for the ester;, said effective amount of said ester being sufficient to increase hair growth in the rat, when said composition is applied topically thereto over a period of no more than three months, by at least 10% more than that obtainable using a control composition from which the said ester has been omitted, in accordance with the Rat Hair Growth Test.

γ-GLUTAMYL PEPTIDES OF VIGNA RADIATA SEEDS

It has been reported elsewerw that Vigna radiata seeds contain a high concentration of γ-glutamyl-S-methylcysteine and its sulphoxide and that these compounds serve as index compounds for the chemotaxonomy of V. radiata.Beside these two γ-glutamyl peptides, nine other γ-glutamyl derivatives, of which three are new compounds, have been isolated and identified from V. radiata seeds.The structures of the new peptides, γ-glutamyl-S-methylcysteinyl-β-alanine (S-methylhomoglutathione), γ-glutamyl-Nδ-acetylornithine and γ-glutamyl-γ-glutamyl-S-methylcysteine, were confirmed by direct comparison with synthetic specimens.The other six γ-glutamyl derivatives were homoglutathione, γ-glutamyl glutamic acid, -aspartic acid, -phenylalanine, -leucine and -isoleucine.Key Word Index- Vigna radiata; Leguminosae; seeds; γ-glutamyl peptides; γ-glutamyl-S-methylcystenyl-β-alanine (S-methylhomoglutathione); γ-glutamyl-Nδ-acetylornithine; γ-glutamyl-γ-glutamyl-S-methylcysteine; homoglutathione; γ-glutamyl derivatives.