622-59-3 Usage
Description
4-Methylphenyl isothiocyanate, also known as p-Tolyl isothiocyanate, is an organic compound with the chemical formula C8H7NS. It is a colorless to pale yellow liquid with a pungent odor and is soluble in organic solvents. It is an isothiocyanate derivative of 4-methylphenol and can be synthesized through various methods, such as the reaction of 4-methylphenol with chlorosulfonyl isocyanate or thionyl chloride.
Uses
Used in Pharmaceutical Industry:
4-Methylphenyl isothiocyanate is used as a pharmaceutical intermediate for the synthesis of various drugs and drug candidates. It is involved in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1,3-dione, which may have potential therapeutic applications.
Used in Biochemistry Research:
4-Methylphenyl isothiocyanate is used as a capping agent to cap the N-terminal ends of polypeptides. This application is particularly useful in biochemistry research, where it helps in the modification and stabilization of polypeptides for further analysis and study.
Check Digit Verification of cas no
The CAS Registry Mumber 622-59-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 622-59:
(5*6)+(4*2)+(3*2)+(2*5)+(1*9)=63
63 % 10 = 3
So 622-59-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NS/c1-7-2-4-8(5-3-7)9-6-10/h2-5H,1H3
622-59-3Relevant articles and documents
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Liebermann,Natanson
, (1881)
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Tetrabutylammonium Iodide/I2 Mediated Convenient and Green Synthesis of Substituted Organic Isothiocyanates
Srivastava, Nitin
, p. 562 - 570 (2021/10/07)
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A catalyst-free method for the synthesis of 1,4,2-dithiazoles from isothiocyanates and hydroxylamine triflic acid salts
An, Zhenyu,Liu, Yafeng,Ren, Yi,Wang, Ting,Yan, Rulong
supporting information, p. 6206 - 6209 (2021/07/28)
A catalyst-free method for the preparation of 1,4,2-dithiazoles is developed by reactions of isothiocyanates with hydroxylamine triflic acid salts. This reaction achieves C-S, C-N, and S-N bond formation, and a range of products are obtained in moderate to good yields. The obvious feature is using shelf-stable hydroxylamine triflic acid salts as a N source to synthesize heterocycles under mild conditions.
