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1-Bromo-3-difluoromethyl-5-fluorobenzene, a halogenated aromatic compound with the molecular formula C7H4BrF3, is a colorless liquid characterized by a strong, pungent odor. It is known for its high reactivity due to the presence of a bromine atom and two fluorine atoms, making it a valuable building block in organic synthesis. This versatile chemical is utilized in the production of pharmaceuticals, agrochemicals, and other organic compounds, contributing to the development of new materials and pharmaceuticals.

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  • 627526-90-3 Structure
  • Basic information

    1. Product Name: 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE
    2. Synonyms: 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE;BENZENE, 1-BROMO-3-(DIFLUOROMETHYL)-5-FLUORO-;3-BroMo-5-fluorodifluoroMethylbenzene;1-Bromo-3-fluoro-5-(difluoromethyl)benzene
    3. CAS NO:627526-90-3
    4. Molecular Formula: C7H4BrF3
    5. Molecular Weight: 225.0058696
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 627526-90-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 191.834 °C at 760 mmHg
    3. Flash Point: 77.885 °C
    4. Appearance: /
    5. Density: 1.633 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE(627526-90-3)
    11. EPA Substance Registry System: 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE(627526-90-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 627526-90-3(Hazardous Substances Data)

627526-90-3 Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-3-difluoromethyl-5-fluorobenzene is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structure and reactivity. It aids in the development of new drugs by providing a platform for further chemical modifications and functionalization.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Bromo-3-difluoromethyl-5-fluorobenzene is employed as a starting material for the production of pesticides and other agrochemicals. Its reactivity and structural properties enable the creation of effective compounds for crop protection and enhancement of agricultural yields.
Used in Organic Synthesis:
1-Bromo-3-difluoromethyl-5-fluorobenzene is utilized as a versatile building block in organic synthesis for the preparation of a wide range of organic compounds. Its unique structure allows for various chemical reactions, leading to the formation of new materials with potential applications in different industries.
It is crucial to handle 1-Bromo-3-difluoromethyl-5-fluorobenzene with care, as it can pose risks to human health and the environment if not managed and disposed of properly.

Check Digit Verification of cas no

The CAS Registry Mumber 627526-90-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,7,5,2 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 627526-90:
(8*6)+(7*2)+(6*7)+(5*5)+(4*2)+(3*6)+(2*9)+(1*0)=173
173 % 10 = 3
So 627526-90-3 is a valid CAS Registry Number.
InChI:InChI=1S/C7H4BrF3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,7H

627526-90-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-bromo-3-(difluoromethyl)-5-fluorobenzene

1.2 Other means of identification

Product number -
Other names 3-fluoro-5-difluoromethyl-1-bromo-benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:627526-90-3 SDS

627526-90-3Relevant articles and documents

HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES

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Page/Page column 111; 112, (2015/11/09)

The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

PROCESS FOR PREPARING TRIAZOLONES

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Page/Page column 18, (2009/01/20)

The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones

Heterocyclic antiviral compounds

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Page/Page column 12, (2010/02/15)

The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficieny virus containing a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.

Non-nucleoside reverse transcriptase inhibitors

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Page/Page column 39, (2008/06/13)

The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R7a, R7b, R7c, R8-R10, X1, X2 m, n, o and p are as defined herein.

Substituted imidazol-pyridazine derivatives

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Page 21, (2010/02/05)

The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.

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