1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE

Base Information

• Chemical Name: 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE
• CAS No.: 627526-90-3
• Molecular Formula: C7H4BrF3
• Molecular Weight: 225.008
• Hs Code.: 2903998090
• Mol file: 627526-90-3.mol

Synonyms:1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE;BENZENE, 1-BROMO-3-(DIFLUOROMETHYL)-5-FLUORO-;3-BroMo-5-fluorodifluoroMethylbenzene

Chemical Property of 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE

Chemical Property:

• Boiling Point: 191.834 °C at 760 mmHg
• Flash Point: 77.885 °C
• PSA: 0.00000
• Density: 1.633 g/cm³
• LogP: 3.52580
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-3-difluoromethyl-5-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE

There total 2 articles about 1-BROMO-3-DIFLUOROMETHYL-5-FLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.3%

3-bromo-5-fluorobenzaldehyde (188813-02-7) → 1-bromo-3-(difluoromethyl)-5-fluorobenzene (627526-90-3)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

→ 1-bromo-3-(difluoromethyl)-5-fluorobenzene (627526-90-3)

Guidance literature:

Reference yield: 89.0%

1-bromo-3-(difluoromethyl)-5-fluorobenzene (627526-90-3) + 1-cyclopropylpiperazine (20327-23-5) → 1-[3-bromo-5-(difluoromethyl)phenyl]piperazine

Guidance literature:

at 200 ℃; for 1h; Microwave irradiation;

upstream raw materials:

3-bromo-5-fluorobenzaldehyde

Downstream raw materials:

3-(difluoromethyl)-5-fluorobenzonitrile

1-bromo-3-difluoromethyl-5-(4-methoxy-benzyloxy)-benzene

3-bromo-5-fluorobenzaldehyde

2-(3-(difluoromethyl)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Refernces

• 1、 -. "PROCESS FOR PREPARING TRIAZOLONES". Page/Page column 18. . Retrieved 2009/01/20.
• 2、 -. "Non-nucleoside reverse transcriptase inhibitors". Page/Page column 39. . Retrieved 2008/06/13.