63132-85-4

Basic information

• Product Name: 3-CHLORO-PROPANE-1-SULFONIC ACID TERT-BUTYLAMIDE
• Synonyms: 1-PROPANESULFONAMIDE, 3-CHLORO-N-(1,1-DIMETHYLETHYL)-;3-CHLORO-PROPANE-1-SULFONIC ACID TERT-BUTYLAMIDE;N-TERT-BUTYL-3-CHLOROPROPANE-1-SULFONAMIDE;3-Chloropropane-1-Sulfonic
• CAS NO: 63132-85-4
• Molecular Formula: C₇H₁₆ClNO₂S
• Molecular Weight: 213.727
• Mol File: 63132-85-4.mol

Chemical Properties

• Melting Point: 70-72 °C(Solv: hexane (110-54-3))
• Boiling Point: 293.735°C at 760 mmHg
• Flash Point: 131.446°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: 2-8°C
• PKA: 11.45±0.40(Predicted)
• CAS DataBase Reference: 3-CHLORO-PROPANE-1-SULFONIC ACID TERT-BUTYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-PROPANE-1-SULFONIC ACID TERT-BUTYLAMIDE(63132-85-4)
• EPA Substance Registry System: 3-CHLORO-PROPANE-1-SULFONIC ACID TERT-BUTYLAMIDE(63132-85-4)

Safety Data

• Hazardous Substances Data: 63132-85-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Chloro-propane-1-sulfonic acid tert-butylamide is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of a wide range of compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-chloro-propane-1-sulfonic acid tert-butylamide is utilized as an intermediate in the manufacturing process of various drugs, playing a crucial role in the synthesis of active pharmaceutical ingredients.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 3-CHLORO-PROPANE-1-SULFONIC ACID TERT-BUTYLAMIDE is employed as an intermediate for the production of various agrochemicals, aiding in the development of substances used in agriculture to protect crops and enhance yields.
Used in Dye and Pigment Manufacturing:
3-Chloro-propane-1-sulfonic acid tert-butylamide is also used in the manufacturing of dyes and pigments, where its chemical properties contribute to the creation of a diverse palette of colors for various applications.

InChI:InChI=1/C7H16ClNO2S/c1-7(2,3)9-12(10,11)6-4-5-8/h9H,4-6H2,1-3H3

Upstream product

• 1633-82-5 3-chloro-n-propanesulfonyl chloride 
• 75-64-9 tert-butylamine 

Downstream Products

• 669008-31-5 N-tert-butyl-(1-benzoyl)cyclopropanesulfonamide 
• 669008-25-7 N-(tert-butyl)-1-methylcyclopropane-1-sulfonamide 
• 669008-33-7 N-tert-butyl-(1-benzyl)cyclopropanesulfonamide 
• 669008-29-1 N-tert-butyl-[1-(1-hydroxy)cyclohexyl]-cyclopropanesulfonamide 
• 630421-42-0 N-t-butyl-1-cyclopropylsulfonamide 

Relevant articles and documents

Toward the Synthesis of Fluorinated Analogues of HCV NS3/4A Serine Protease Inhibitors Using Methyl α-Amino-β-fluoro-β-vinylcyclopropanecarboxylate as Key Intermediate

Synthesis of fluorocyclopropyl building blocks, which constitute the core of various therapeutic agents against the hepatitis C virus, is described. The relevant methyl α-amino-β-fluoro-β-vinylcyclopropanecarboxylate has been used as a key intermediate for the total synthesis of a fluorinated analogue of Simeprevir (TMC 435), a HCV NS3/4A protease inhibitor.

Preparation of cyclopropyl sulfonylamides

A novel process for the preparation of cyclopropyl sulfonamide of the formula I is described. Cyclopropyl sulfonamide is a versatile building block for many biologically active compounds.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Inhibitors of Hepatitis C Virus

Macrocyclic peptides are disclosed having the general formula: wherein R3, R3′, R4, R6, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

MACROCYCLIC PEPTIDES AS HEPATITIS C VIRUS INHIBITORS

Macrocyclic peptides having the general formula (I): are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Inhibitors of Hepatitis C Virus

Macrocyclic peptides are disclosed having the general formula: wherein R3, R3′, R4, R6, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Inhibitors of Hepatitis C Virus

Macrocyclic peptides are disclosed having the general formula: wherein R3, R′3, R4, R6, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

MACROCYCLIC PEPTIDES AS HEPATITIS C VIRUS INHIBITORS

Macrocyclic peptides having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.