Welcome to LookChem.com Sign In|Join Free

CAS

  • or

63572-67-8

2-(1H-BENZIMIDAZOL-2-YL)-4-CHLORO-3-OXOBUTANENITRILE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

63572-67-8 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 63572-67-8 Structure

  • Basic information

    1. Product Name: 2-(1H-BENZIMIDAZOL-2-YL)-4-CHLORO-3-OXOBUTANENITRILE
    2. Synonyms: ASISCHEM C58350;2-(1H-BENZIMIDAZOL-2-YL)-4-CHLORO-3-OXOBUTANENITRILE;AKOS BBS-00004653
    3. CAS NO:63572-67-8
    4. Molecular Formula: C11H8ClN3O
    5. Molecular Weight: 233.65
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 63572-67-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(1H-BENZIMIDAZOL-2-YL)-4-CHLORO-3-OXOBUTANENITRILE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(1H-BENZIMIDAZOL-2-YL)-4-CHLORO-3-OXOBUTANENITRILE(63572-67-8)
    11. EPA Substance Registry System: 2-(1H-BENZIMIDAZOL-2-YL)-4-CHLORO-3-OXOBUTANENITRILE(63572-67-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 63572-67-8(Hazardous Substances Data)

63572-67-8 Usage

Explanation

The compound's chemical composition consists of 11 carbon atoms, 7 hydrogen atoms, 1 chlorine atom, 4 nitrogen atoms, and 1 oxygen atom.

Explanation

The physical form of the compound is a yellow to brown colored powder.

Explanation

The compound dissolves easily in organic solvents such as ethanol and dimethyl sulfoxide, which is useful for its handling and application in research and pharmaceuticals.
4. Potential use as an antifungal agent

Explanation

Studies have been conducted on the compound to explore its potential as an antifungal agent, which could be useful in treating fungal infections.
5. Inhibitory effects on certain enzymes

Explanation

The compound has been shown to have inhibitory effects on specific enzymes, which could be beneficial in the development of new therapies for various medical conditions.

Explanation

The compound's structure contains a benzimidazole ring, a chlorine atom, and a nitrile group attached to a ketone. These features make it a versatile molecule for medicinal chemistry and drug development.
7. Applications in research and pharmaceuticals

Explanation

Due to its unique structure and properties, the compound is commonly used in research and pharmaceutical applications to better understand biological systems and develop new therapies for various medical conditions.

Appearance

Yellow to brown powder

Solubility

Soluble in organic solvents like ethanol and dimethyl sulfoxide

Structural features

Benzimidazole ring, chlorine atom, nitrile group, and ketone

Check Digit Verification of cas no

The CAS Registry Mumber 63572-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,5,7 and 2 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 63572-67:
(7*6)+(6*3)+(5*5)+(4*7)+(3*2)+(2*6)+(1*7)=138
138 % 10 = 8
So 63572-67-8 is a valid CAS Registry Number.

63572-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(1H-benzoimidazol-2-yl)-4-chloro-3-oxo-butyronitrile

1.2 Other means of identification

Product number -
Other names 2-(1H-Benzoimidazol-2-yl)-4-chloro-3-oxo-butyronitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:63572-67-8 SDS

63572-67-8Relevant articles and documents

Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1

Gryshchenko,Tarnavskiy,Levchenko,Bdzhola,Volynets,Golub,Ruban,Vygranenko,Lukash,Yarmoluk

, p. 2053 - 2059 (2016/04/20)

Fibroblast growth factor receptor 1 (FGFR1) plays an important role in tumorigenesis and is therefore an attractive target for anticancer therapy. Using molecular docking approach we have identified inhibitor of FGFR1 belonging to 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones with IC50 value of 3.5 μM. A series of derivatives of this chemical scaffold has been synthesized and evaluated for inhibition of FGFR1 kinase activity. It was revealed that the most promising compounds 5-amino-1-(3-hydroxy-phenyl)-4-(6-methyl-1H-benzoimidazol-2-yl)-1,2-dihydro-pyrrol-3-one and 5-amino-4-(1H-benzoimidazol-2-yl)-1-(3-hydroxy-phenyl)-1,2-dihydro-pyrrol-3-one inhibit FGFR1 with IC50 values of 0.63 and 0.32 μM, respectively, and posses antiproliferative activity against KG1 myeloma cell line with IC50 values of 5.6 and 9.3 μM. Structure-activity relationships have been studied and binding mode of this chemical class has been proposed.

Synthesis of New Heterocyclic Benzimidazole Derivatives Based on 2-Cyanomethylbenzimidazole

Zielinski, W.,Zaki, M. E. A.

, p. 1569 - 1574 (2007/10/02)

It was found that N-acyl derivatives of 2-cyanomethylbenzimidazole (2) may form fused heterocyclic systems and, through 1-3 migration of acyl groups into more thermodynamically stable C-acyl derivatives (3), ring assembled systems.A migration of acyl groups in reverse direction in C-acyl derivatives (3) was observed.Key words: 2-cyanomethylbenzimidazole, acylation, migration of acyl groups, heterocyclic benzimidazole derivatives

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 63572-67-8