65000-12-6

Basic information

• Product Name: 2-Bromo-N,N-diethylbenzenesulphonamide
• Synonyms: 2-Bromo-N,N-diethylbenzenesulphonamide;2-Bromo-N,N-diethylbenzenesulfonamide;N,N-Diethyl 2-bromobenzenesulfonamide
• CAS NO: 65000-12-6
• Molecular Formula: C₁₀H₁₄BrNO₂S
• Molecular Weight: 292.2
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 65000-12-6.mol

Chemical Properties

• Melting Point: 76-78 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 365.4 °C at 760 mmHg
• Flash Point: 174.8 °C
• Appearance: /
• Density: 1.431 g/cm³
• Vapor Pressure: 1.57E-05mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -5.61±0.70(Predicted)
• CAS DataBase Reference: 2-Bromo-N,N-diethylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N,N-diethylbenzenesulphonamide(65000-12-6)
• EPA Substance Registry System: 2-Bromo-N,N-diethylbenzenesulphonamide(65000-12-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 65000-12-6(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-Bromo-N,N-diethylbenzenesulphonamide is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure, featuring a benzene ring, sulfonyl group, bromine atom, and diethylamine functional group, allows it to participate in a range of chemical reactions, facilitating the production of desired products in the chemical industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Bromo-N,N-diethylbenzenesulphonamide is used as a building block for the development of new drugs. Its chemical properties enable it to be incorporated into the molecular structures of potential therapeutic agents, contributing to the discovery and design of novel pharmaceutical compounds with specific therapeutic effects.
Used in Research and Development:
2-Bromo-N,N-diethylbenzenesulphonamide is utilized as a research compound in academic and industrial laboratories. Its reactivity and structural features make it a valuable tool for studying various chemical reactions and processes, aiding in the advancement of scientific knowledge and the development of innovative applications.

InChI:InChI=1/C10H14BrNO2S/c1-3-12(4-2)15(13,14)10-8-6-5-7-9(10)11/h5-8H,3-4H2,1-2H3

Upstream product

• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 109-89-7 diethylamine 
• 615-36-1 2-bromoaniline 
• 1319750-41-8 1-(2-bromophenyl)-3,3-diethyltriaz-1-ene 
• 121-44-8 triethylamine 
• 60199-33-9 ortho-bromobenzenesulfonyl hydrazide 
• 108-86-1 bromobenzene 

Downstream Products

• 65000-18-2 N-ethyl-N-vinylbenzenesulfonamide 

Relevant articles and documents

An approach to C-N activation: Coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with: Tert -amines via a metal-, oxidant- and halogen-free anodic oxidation

tert-Amines were harnessed to afford arenesulfonyl hydrazides and arenesulfonyl chlorides via a metal-, oxidant- and halogen-free electrochemical oxidative coupling in an undivided cell at RT. This environmentally benign approach afforded a wide spectrum of sulfonamides in satisfactory yields using cheap and renewable Pencil Graphite Electrodes (PGEs).

Para-Selective Alkylation of Sulfonylarenes by Cooperative Nickel/Aluminum Catalysis

A method for the para-selective alkylation of a variety of arenesulfonamides and aromatic sulfones with 1-alkenes by cooperative nickel/aluminum catalysis has been developed. Taking advantage of the sulfornyl functionality serving as a removable ortho-directing group, the reaction can be applied to facile access to 1,3-dialkyl-substitued benzenes.

Synthesis of sulfonamides: Via copper-catalyzed oxidative C-N bond cleavage of tertiary amines

A copper-catalyzed coupling reaction of sulfonyl chlorides with tertiary amines via the oxidative C-N bond cleavage of tertiary amines was developed. Sulfonamides were synthesized using this strategy in moderate to good yields. The reaction was applicable to various tertiary amines, as well as sulfonyl chlorides.

Catalytic conversion of aryl triazenes into aryl sulfonamides using sulfur dioxide as the sulfonyl source

Various sulfonamides have been synthesized from triazenes and sulfur dioxide. In the presence of just a catalytic amount of BF3· OEt2, a series of 1-aryl-triazenes were converted into sulfonyl hydrazines in good to excellent yields. When using CuCl2 as the catalyst, the corresponding sulfonamides can be produced from the 1-aryl triazenes in good yields. This journal is the Partner Organisations 2014.

Palladium-catalysed dehydrogenative sp3 C-H bonds functionalisation into alkenes: A direct access to N-alkenylbenzenesulfonamides

The palladium-catalysed dehydrogenation of sp3 carbon-hydrogen bonds of N-alkylbenzenesulfonamides allows a simple access to N-alkenylbenzenesulfonamides. The reaction proceeds with easily accessible catalysts, with pivalate as a base, and allo