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BOC-HIS(TOS)-OH DCHA is a chemical compound that features a BOC-protected histidine (BOC-HIS) with a tosyl (TOS) functional group attached to the nitrogen atom. The DCHA group is attached to the carboxylic acid, acting as a protecting group. BOC-HIS(TOS)-OH DCHA is widely recognized for its role as a building block in peptide synthesis, where the BOC protecting group can be removed under mild acidic conditions to expose the free amine group for peptide coupling reactions. The tosyl group provides additional selectivity in peptide synthesis, making BOC-HIS(TOS)-OH DCHA a valuable tool in the construction of complex peptides in organic chemistry.

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  • N-cyclohexylcyclohexanamine; (2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-(tert-butoxycarbonylamino)propanoic acid

    Cas No: 65057-34-3

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  • N-cyclohexylcyclohexanamine; (2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-(tert-butoxycarbonylamino)propanoic acid

    Cas No: 65057-34-3

  • USD $ 1.0-1.0 / Metric Ton

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  • 65057-34-3 Structure
  • Basic information

    1. Product Name: BOC-HIS(TOS)-OH DCHA
    2. Synonyms: BOC-N-IM-4-TOLUENESYLFONYL-L-HISTIDINE DICYCLOHEXYLAMMONIUM SALT;BOC-NIM-TOSYL-L-HISTIDINE DCHA SALT;BOC-L-HISTIDINE(TOSYL) DCHA SALT;BOC-L-HIS(TOS)-OH DCHA;BOC-HIS(TOS)-OH DCHA;N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TOSYL-L-HISTIDINE DICYCLOHEXYLAMINE;N-ALPHA-BOC-N(IM)-TOSYL-LHISTIDINE DICYCLOHEXYLAMINE SALT;Boc-His(Tos)-OH dicyclohexylamine salt
    3. CAS NO:65057-34-3
    4. Molecular Formula: C12H23N*C18H23N3O6S
    5. Molecular Weight: 590.77
    6. EINECS: 265-328-0
    7. Product Categories: AMINOACIDS DERIVATIVES;Amino Acids;Boc-Amino Acids and Derivative
    8. Mol File: 65057-34-3.mol
  • Chemical Properties

    1. Melting Point: ~165 °C (dec.)
    2. Boiling Point: 766.9°C at 760 mmHg
    3. Flash Point: 417.6°C
    4. Appearance: /Solid
    5. Density: N/A
    6. Vapor Pressure: 9.83E-25mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: BOC-HIS(TOS)-OH DCHA(CAS DataBase Reference)
    11. NIST Chemistry Reference: BOC-HIS(TOS)-OH DCHA(65057-34-3)
    12. EPA Substance Registry System: BOC-HIS(TOS)-OH DCHA(65057-34-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. F: 10-21
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 65057-34-3(Hazardous Substances Data)

65057-34-3 Usage

Uses

Used in Organic Chemistry:
BOC-HIS(TOS)-OH DCHA is used as a building block for the synthesis of complex peptides, offering a versatile approach to creating diverse peptide structures. The BOC protecting group allows for mild acidic deprotection, facilitating the coupling of amino acids in peptide synthesis.
Used in Peptide Synthesis:
In the field of peptide synthesis, BOC-HIS(TOS)-OH DCHA is utilized as a protected amino acid, enabling chemists to selectively incorporate histidine into peptide sequences. The tosyl group on the histidine side chain provides an additional level of selectivity, which is crucial for the synthesis of peptides with specific properties and functions.
Used in Pharmaceutical Development:
BOC-HIS(TOS)-OH DCHA is employed in the development of pharmaceuticals, particularly in the synthesis of peptide-based drugs. Its role in peptide synthesis allows for the creation of bioactive peptides with potential therapeutic applications.
Used in Research Laboratories:
In research settings, BOC-HIS(TOS)-OH DCHA is used for studying the synthesis and properties of peptides. Its versatility as a building block in peptide synthesis makes it an essential tool for exploring the structure-function relationships of peptides and their potential applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 65057-34-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,5 and 7 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 65057-34:
(7*6)+(6*5)+(5*0)+(4*5)+(3*7)+(2*3)+(1*4)=123
123 % 10 = 3
So 65057-34-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H23N3O6S.C12H23N/c1-12-5-7-14(8-6-12)28(25,26)21-10-13(19-11-21)9-15(16(22)23)20-17(24)27-18(2,3)4;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h5-8,10-11,15H,9H2,1-4H3,(H,20,24)(H,22,23);11-13H,1-10H2/t15-;/m0./s1

65057-34-3 Well-known Company Product Price

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  • Alfa Aesar

  • (H62205)  N-Boc-1-(p-toluenesulfonyl)-L-histidine dicyclohexylammonium salt, 98%   

  • 65057-34-3

  • 5g

  • 328.0CNY

  • Detail
  • Alfa Aesar

  • (H62205)  N-Boc-1-(p-toluenesulfonyl)-L-histidine dicyclohexylammonium salt, 98%   

  • 65057-34-3

  • 25g

  • 1310.0CNY

  • Detail

65057-34-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoate

1.2 Other means of identification

Product number -
Other names N-cyclohexylcyclohexanamine,(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:65057-34-3 SDS

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