65994-70-9

Basic information

• Product Name: dipropargylacetic acid
• Synonyms: dipropargylacetic acid
• CAS NO: 65994-70-9
• Molecular Weight: 136.15
• Mol File: 65994-70-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: dipropargylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: dipropargylacetic acid(65994-70-9)
• EPA Substance Registry System: dipropargylacetic acid(65994-70-9)

Safety Data

• Hazardous Substances Data: 65994-70-9(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-96-7 propargyl bromide 
• 99179-69-8 allyl-prop-2-ynyl-malonic acid 
• 181478-00-2 methyl 2-(prop-2-yn-1-yl)pent-4-ynoate 
• 17920-23-9 diethyl propargylmalonate 
• 2689-88-5 diethyl 2,2-di(prop-2-yn-1-yl)malonate 
• 107428-06-8 dimethyl allylpropargylmalonate 
• 63104-44-9 dimethyl 2,2-di(prop-2-ynyl)malonate 
• 111218-05-4 2-acetyl-4-bromo-2-(2-bromo-prop-2-enyl)-pent-4-enoic acid ethyl ester 
• 4431-32-7 2,2-di(prop-2-ynyl)propan-1,3-dioic acid 

Downstream Products

• 109257-45-6 2-(2-propinyl)-4-pentinoic acid anilide 
• 112404-95-2 2-(2-propinyl)-4-pentinoic acid N-benzylamide 
• 112404-90-7 N-phenyl-N'-(2-(2-propinyl)-4-pentinoyl)thiourea 
• 112404-89-4 N-benzyl-N'-(2-(2-propinyl)-4-pentinoyl)thiourea 
• 112404-91-8 N,N-diphenyl-N'-(2-(2-propinyl)-4-pentinoyl)thiourea 
• 107428-15-9 methyl N-(hepta-1,6-diyn-4-oyl)anthranilate 
• 99-04-7 m-Toluic acid 
• 106950-10-1 3-methyl-5-oxo-3-cyclohexene-1-carboxylic acid 

Relevant articles and documents

Monomeric Cinchona Alkaloid-Based Catalysts for Highly Enantioselective Bromolactonisation of Alkynes

The cinchona alkaloid dimer (DHQD)2PHAL has been shown to be a broadly applicable catalyst for asymmetric halogenations. However, this catalyst does not have to be dimeric and a class of monomeric quinidine and quinine-derived catalysts was prepared, often showing superior selectivity in bromolactonisations of terminal alkynoic acids. Mechanistic investigations show that these organocatalysts act as host molecules that can bind carboxylic acid-based substrates as guests with substantial binding constants. Based on these findings, it is proposed that this class of catalysts is bifunctional in nature activating the halogenating agent as well as the nucleophile in electrophilic halogenation reactions.

Oxidative rearrangement of malondialdehyde: Substrate scope and mechanistic insights

A novel oxidative rearrangement of malondialdehyde was described. Under the effect of H2O2, malondialdehyde smoothly transferred to carboxylic acid with C-C bond cleavage in good to excellent yields. Mechanistic studies showed that this reaction proceeded via the formation of a 1,2-dioxolane intermediate, followed by concert C-C, O-O, C-H bond cleavage and a hydride shift.

BINDING-SITE MODIFIED LECTINS AND USES THEREOF

In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one covalently linked affinity ligand which is capable of competing with gluco