66131-70-2

Basic information

• Product Name: 2-Pyrimidinamine, N-ethyl- (9CI)
• Synonyms: 2-Pyrimidinamine, N-ethyl- (9CI);2-(N-ethylamino)pyrimidine
• CAS NO: 66131-70-2
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.15576
• Product Categories: PYRIMIDINE
• Mol File: 66131-70-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 50-51 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 228.9±23.0 °C(Predicted)
• Appearance: /
• Density: 1.101±0.06 g/cm3(Predicted)
• PKA: 3.89±0.10(Predicted)
• CAS DataBase Reference: 2-Pyrimidinamine, N-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, N-ethyl- (9CI)(66131-70-2)
• EPA Substance Registry System: 2-Pyrimidinamine, N-ethyl- (9CI)(66131-70-2)

Safety Data

• Hazardous Substances Data: 66131-70-2(Hazardous Substances Data)

Upstream product

• 109-12-6 2-aminopyrimidine 
• 5796-97-4 bis(triethylsilyl) peroxide 
• 20232-76-2 1,2-dihydro-1-ethyl-2-iminopyrimidine hydroiodide 
• 1722-12-9 2-chloropyrimidine 
• 75-04-7 ethylamine 
• 64-17-5 ethanol 

Downstream Products

• 918801-64-6 1-ethyl-5-(4-fluorophenyl)-1H-imidazol-2-ylamine 

Relevant articles and documents

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Alkylsilyl Peroxides as Alkylating Agents in the Copper-Catalyzed Selective Mono-N-Alkylation of Primary Amides and Arylamines

The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the alkylsilyl peroxides, as well as to the primary amides and arylamines. Mechanistic studies suggest that the present reaction should proceed through a free-radical process that includes alkyl radicals generated from the alkylsilyl peroxides.

A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines

(Chemical Equation Presented) A new divergent and efficient synthesis of substituted 2-aminoimidazoles 5 and 6 has been developed starting from the readily available 2-aminopyrimidines 1 and α-bromocarbonyl compounds 2, using conventional heating or microwave irradiation. Thus, the cleavage of 1,2,3-substituted imidazo[1,2-a]pyrimidin-1-ium salts 4 with hydrazine or secondary amines led to 1,4,5-trisubstituted 2-aminoimidazoles 5, when the hydrazinolysis of 2-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium salts 3, followed by a novel Dimroth-type rearrangement, resulted in formation of 2-amino-1H-imidazoles 6. The relevant pathway of transformations was identified by characterization of the intermediates.