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6-Hydroxy-5-nitronicotinic acid is a chemical compound derived from nicotinic acid, also known as vitamin B3 or niacin. It is characterized by the addition of a hydroxy group and a nitro group to the nicotinic acid structure, which significantly alters its chemical properties. 6-Hydroxy-5-nitronicotinic acid is primarily used in research and scientific studies, with its potential applications and roles not being well defined in the literature. Due to the lack of safety and toxicity data, it is mostly relevant in controlled experimental settings.

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  • 6635-31-0 Structure
  • Basic information

    1. Product Name: 6-Hydroxy-5-nitronicotinic acid
    2. Synonyms: 5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE;6-HYDROXY-5-NITRONICOTINIC ACID;2-HYDROXY-3-NITRO-5-PYRIDINECARBOXYLIC ACID;2-HYDROXY-3-NITROPYRIDINE-5-CARBOXYLIC ACID;6-Hydroxy-5-nitronicotinic acid 97%;6-hyroxy-5-nitronicotinic acid;6-Hydroxy-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-hydroxy-3-nitropyridine
    3. CAS NO:6635-31-0
    4. Molecular Formula: C6H4N2O5
    5. Molecular Weight: 184.11
    6. EINECS: N/A
    7. Product Categories: blocks;Carboxes;NitroCompounds;Pyridines;CHIRAL CHEMICALS
    8. Mol File: 6635-31-0.mol
  • Chemical Properties

    1. Melting Point: 269-271
    2. Boiling Point: 463.434 °C at 760 mmHg
    3. Flash Point: 234.076 °C
    4. Appearance: /
    5. Density: 1.746 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Keep Cold
    8. Solubility: N/A
    9. PKA: 3.09±0.50(Predicted)
    10. BRN: 177986
    11. CAS DataBase Reference: 6-Hydroxy-5-nitronicotinic acid(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-Hydroxy-5-nitronicotinic acid(6635-31-0)
    13. EPA Substance Registry System: 6-Hydroxy-5-nitronicotinic acid(6635-31-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6635-31-0(Hazardous Substances Data)

6635-31-0 Usage

Uses

Used in Research and Scientific Studies:
6-Hydroxy-5-nitronicotinic acid is used as a research compound for [application reason] in the field of [application industry]. Its unique chemical structure, with a hydroxy and nitro group, allows for exploration of its properties and potential interactions with other molecules, making it a valuable tool in scientific investigations.
Used in Pharmaceutical Research:
6-Hydroxy-5-nitronicotinic acid is used as a potential drug candidate for [application reason] in the pharmaceutical industry. Its structural modifications from the parent compound, nicotinic acid, may offer new avenues for drug development, particularly in the context of diseases where nicotinic acid has shown therapeutic potential.
Used in Chemical Synthesis:
6-Hydroxy-5-nitronicotinic acid is used as a synthetic intermediate for [application reason] in the chemical industry. Its unique structure may serve as a building block for the synthesis of more complex molecules, contributing to the development of novel compounds with potential applications in various fields.
Note: Since the provided materials do not specify the exact applications or industries for 6-Hydroxy-5-nitronicotinic acid, the above uses are hypothetical and based on the general properties of the compound. Further research and data would be required to confirm its specific uses and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 6635-31-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,3 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6635-31:
(6*6)+(5*6)+(4*3)+(3*5)+(2*3)+(1*1)=100
100 % 10 = 0
So 6635-31-0 is a valid CAS Registry Number.

6635-31-0 Well-known Company Product Price

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  • (Code)Product description
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  • Aldrich

  • (669679)  6-Hydroxy-5-nitropyridine-3-carboxylicacid  97%

  • 6635-31-0

  • 669679-1G

  • 950.04CNY

  • Detail
  • Aldrich

  • (669679)  6-Hydroxy-5-nitropyridine-3-carboxylicacid  97%

  • 6635-31-0

  • 669679-5G

  • 3,542.76CNY

  • Detail

6635-31-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Hydroxy-5-nitropyridine-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 5-nitro-6-oxo-1H-pyridine-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6635-31-0 SDS

6635-31-0Relevant articles and documents

A 6-hydroxy-5-nitro-nicotinic acid synthetic method and its separating and purifying method

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Paragraph 0045-0064, (2018/02/04)

The invention discloses a synthetic method and a separation purification method of 6-hydroxyl-5-nitro niacin and belongs to the field of fine chemical engineering. According to the method, 6-hydroxyl niacin is used as a raw material and is subjected to pre-nitration reaction under the action of concentrated sulfuric acid, concentrated nitric acid and a catalyst ammonium bisulfate, nitration reaction, crystal separation purification and the like to obtain highly purified 6- hydroxyl-5-nitro niacin to meet purity requirements on midbody by pharmaceutical synthetic fields. The synthetic method has the advantages of being simple in synthetic process, mild in condition, high in yield, high in purity of obtained product, easy to operate and the like and is suitable for industrial production.

INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE

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Paragraph 00372, (2016/09/22)

The invention provides indazolyl thiadiazolamines and related compounds, pharmaceutical compositions, methods of inhibiting Rho-associated protein kinase, and methods of treating inflammatory disorders, immune disorders, fibrotic disorders, and other medical disorders using such compounds. An exemplary indazolyl thiadiazolamine compound is an N-(5-[5-[(1H4ndazol-5-yl)amino]-1,3,4-thiadiazol-2-yl]pyridin-3-yl)acetamide compound.

NOVEL COMPOUND, PRODUCTION METHOD THEREFOR, AND APPLICATION THEREFOR

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Paragraph 0188; 0190-0192, (2016/11/09)

[Problems] To provide a novel peptide synthesis technique that is completely different than heretofore, and to provide a novel compound that enables the synthesis/creation of a novel artificial functional protein and the synthesis/creation of a novel functional peptide, as well as a method for producing the same. [Solution] A compound represented by formula (I) or a salt thereof.

NITROGENATED HETEROCYCLIC COMPOUND

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Paragraph 1032, (2015/03/28)

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

Development of a solid-supported biotinylation reagent for efficient biotin labeling of SH groups on small molecules

Fukumoto, Kentarou,Adachi, Kumi,Kajiyama, Akihiro,Yamazaki, Yuri,Yakushiji, Fumika,Hayashi, Yoshio

supporting information; experimental part, p. 535 - 538 (2012/03/11)

We report here the design and synthesis of a novel and selective SH-group biotinylating reagent, KSH-1 (1), for the biotinylation of small molecules using solid phase chemistry. The results demonstrate that 1 efficiently biotinylated a small molecule, cap

Identification of a sulfonamide series of CCR2 antagonists

Peace, Simon,Philp, Joanne,Brooks, Carl,Piercy, Val,Moores, Kitty,Smethurst, Chris,Watson, Steve,Gaines, Simon,Zippoli, Mara,Mookherjee, Claudette,Ife, Robert

scheme or table, p. 3961 - 3964 (2010/09/03)

A series of sulfonamide CCR2 antagonists was identified by high-throughput screening. Management of molecular weight and physical properties, in particular moderation of lipophilicity and study of pKa, yielded highly potent CCR2 antagonists exh

The design of efficient and selective routes to pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes

Brooks, Gerald,Dabbs, Steven,Davies, David T.,Hennessy, Alan J.,Jones, Graham E.,Markwell, Roger E.,Miles, Timothy J.,Owston, Nathan A.,Pearson, Neil D.,Peng, Tony W.

scheme or table, p. 5035 - 5037 (2011/01/04)

This Letter describes the synthesis of challenging pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes. The six different routes described are high yielding, contain no major purification issues and have been used to give gram quantities of each aldehyde.

N3-substituted imidazopyridine c-Kit inhibitors

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Page/Page column 11; 14-15, (2008/06/13)

Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.

BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE

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Page/Page column 221, (2008/06/13)

Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.

N3-SUBSTITUTED IMIDAZOPYRIDINE C-KIT INHIBITORS

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Page/Page column 29, (2008/06/13)

Compounds represented by Formula (I): (I) or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.

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