66774-80-9

Basic information

• Product Name: Inhoffen Lythgoe Diol Monotosylate
• Synonyms: (S,1R,3aR,4S,7aR)-Octahydro-4-hydroxy-,7a-dimethyl-1H-indene-1-ethanol 1-(4-Methylbenzenesulfonate);Inhoffen Lythgoe Diol Monotosylate;1H-Indene-1-ethanol, octahydro-4-hydroxy-b, 7a-diMethyl-1-(4-Methylbenzenesulfonate),(bS, 1R, 3aR, 4S, 7aR)
• CAS NO: 66774-80-9
• Molecular Formula: C₂₀H₃₀O₄S
• Molecular Weight: 366.51
• Product Categories: Chiral Reagents;Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 66774-80-9.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 498.382°C at 760 mmHg
• Flash Point: 255.213°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Inhoffen Lythgoe Diol Monotosylate(CAS DataBase Reference)
• NIST Chemistry Reference: Inhoffen Lythgoe Diol Monotosylate(66774-80-9)
• EPA Substance Registry System: Inhoffen Lythgoe Diol Monotosylate(66774-80-9)

Safety Data

• Hazardous Substances Data: 66774-80-9(Hazardous Substances Data)

Usage

Uses

Vitamin D analog.

InChI:InChI=1/C20H30O4S/c1-14-6-8-16(9-7-14)25(22,23)24-13-15(2)17-10-11-18-19(21)5-4-12-20(17,18)3/h6-9,15,17-19,21H,4-5,10-13H2,1-3H3/t15-,17-,18+,19?,20?/m1/s1

Upstream product

• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 104-15-4 toluene-4-sulfonic acid 
• 50-14-6 Calciferol 

Downstream Products

• 100858-19-3 de-A,B-8β-(benzoyloxy)-23,24-dinor-22-(tosyloxy)cholane 
• 930767-53-6 (1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene 
• 930767-56-9 1α,2β,3β-tris(triethylsilyloxy)-24S,25-di(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene 
• 930767-57-0 1α,2β,3β-tris(triethylsilyloxy)-24R,25-di(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene 
• 239100-21-1 (1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]octahydro-1H-inden-4-ol 
• 154082-42-5 [(1R,3aR,4S,7aR)-1-((S)-2-Benzenesulfonyl-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-trimethyl-silane 
• 1026272-78-5 (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((1R,4R)-4-ethyl-1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene 
• 113490-39-4 25-hydroxy-3-deoxy-2-oxavitamin D₃ 
• 113490-37-2 2-nor-1,3-seco-1,25-dihydroxyvitamin D₃ 
• 1258066-59-9 (20S)-2-methylene-22-(imidazol-1-yl)-19,23,24,25,26,27-esanor-1α-hydroxyvitamin D3 
• 248257-32-1 Toluene-4-sulfonic acid (R)-2-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyl-octahydro-inden-1-yl)-propyl ester 
• 725227-40-7 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 725227-35-0 2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol 

Relevant articles and documents

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Synthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3

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