100858-19-3Relevant academic research and scientific papers
Two Novel Allenic Side Chain Analogues of 1α,25-Dihydroxyvitamin D3 (1a)
Craig, Andrew S.,Norman, Anthony W.,Okamura, William H.
, p. 4374 - 4380 (2007/10/02)
Two new analogues of the steroid hormone 1α,25-dihydroxyvitamin D3 (1) in which allenic functionality has been incorporated into the side chain have been synthesized.Both the 22S and 22R allene analogues (2a and 2b) were each separately synthesized in nin
Studies on the Synthesis of Side-Chain Hydroxylated Metabolites of Vitamin D. 2. Stereocontrolled Synthesis of 25-Hydroxyvitamin D2
Sardina, F. Javier,Mourino, Antonio,Castedo, Luis
, p. 1264 - 1269 (2007/10/02)
An efficient synthesis of 25-hydroxyvitamin D2 is described.The chiral center at C-24 was introduced by the stereospecific and regioselective displacement of an allylic carbamate by a cuprate.The triene system was assembled by Horner-Wittig coupling of ke
