67130-14-7Relevant articles and documents
Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii
Kopańska, Katarzyna,Najda, Andzelika,Zebrowska, Justyna,Chomicz, Lidia,Piekarczyk, Janusz,Myjak, Przemys?aw,Bretner, Maria
, p. 2617 - 2624 (2007/10/03)
Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.
A NEW SYNTHESIS OF DIAMINOPREHNITOL
D'yachenko, E. K.,Pesin, V. G.,Papirnik, M. P.
, p. 372 - 375 (2007/10/02)
The reaction of 4,7-di(chloromethyl)-5,6-dimethylbenzo-2,1,3-thiadiazole with a small excess of tin(II) chloride leads to a high yield of tetramethylbenzo-2,1,3-thiadiazole.With a large excess of tin chloride the thiadiazole ring is cleaved to 1,2,3,4-tet