68697-61-0

Basic information

• Product Name: DL-TYROSINE METHYL ESTER HCL
• Synonyms: methyl DL-tyrosinate hydrochloride;(±)-Tyrosine methyl ester hydrochloride;H-DL-Tyr-OMe;2-Amino-3-(4-hydroxyphenyl)propionic acid methyl ester hydrochloride;Methyl 2-amino-3-(4-hydroxyphenyl);DL-TYROSINE METHYL ESTER HCL
• CAS NO: 68697-61-0
• Molecular Formula: C₁₀H₁₄NO₃*Cl
• Molecular Weight: 231.67606
• EINECS: 272-084-9
• Mol File: 68697-61-0.mol

Chemical Properties

• Boiling Point: 330oC at 760 mmHg
• Flash Point: 153.4oC
• Appearance: /
• Vapor Pressure: 8.89E-05mmHg at 25°C
• Storage Temp.: −20°C
• CAS DataBase Reference: DL-TYROSINE METHYL ESTER HCL(CAS DataBase Reference)
• NIST Chemistry Reference: DL-TYROSINE METHYL ESTER HCL(68697-61-0)
• EPA Substance Registry System: DL-TYROSINE METHYL ESTER HCL(68697-61-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 68697-61-0(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
DL-Tyrosine Methyl Ester HCl is used as a research compound for studying enzymology, neurotransmitter regulation, and pharmacological investigations. Its enhanced lipophilicity and stability make it a valuable tool in understanding the complex interactions and processes within biological systems.
Used in Pharmaceutical Development:
DL-Tyrosine Methyl Ester HCl is used as a starting material or intermediate in the synthesis of various pharmaceutical compounds. Its unique properties, such as increased lipophilicity and stability, can contribute to the development of new drugs with improved efficacy and bioavailability.
Used in Enzyme Studies:
DL-Tyrosine Methyl Ester HCl is used as a substrate or inhibitor in enzyme studies, particularly those involving enzymes that act on tyrosine-containing compounds. Its modified structure allows researchers to investigate the enzyme's specificity, activity, and mechanism of action.
Used in Neurotransmitter Regulation Research:
DL-Tyrosine Methyl Ester HCl is used as a research tool in studies focused on neurotransmitter regulation, as tyrosine is a precursor to several neurotransmitters, including dopamine, norepinephrine, and epinephrine. Understanding the role of DL-TYROSINE METHYL ESTER HCL in neurotransmitter synthesis and regulation can provide insights into neurological disorders and potential therapeutic interventions.

InChI:InChI=1/C10H13NO3.ClH/c1-14-10(13)9(11)6-7-2-4-8(12)5-3-7;/h2-5,9,12H,6,11H2,1H3;1H/t9-;/m0./s1

Upstream product

• 67-56-1 methanol 
• 142847-18-5 N-(tert-butoxycarbonyl)tyrosine 
• 556-02-5 ?Tyr 

Downstream Products

• 556-02-5 tyrosine 
• 3410-66-0 D-tyrosine methyl ester 
• 60-18-4 L-tyrosine 
• 21467-33-4 N-benzyloxycarbonyl-D,L-tyrosine methyl ester 
• 60142-79-2 methyl N-(4-methoxybenzoyl)-phenylalanyltyrosinate 
• 35047-20-2 2-diazo-3-(4-hydroxyphenyl)propanoic acid methyl ester 
• 18621-06-2 methyl trityltyrosinate 

Relevant articles and documents

(2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative as well as preparation method and application thereof

The invention discloses a (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative shown as a formula (I) or an optical isomer, a diastereomer and racemate mixture and pharmaceutically acceptable salt thereof as well as a preparation method and application of the (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative. It is shown by comparison of results of a positive control group and a model group on lymphedema prevention experiments that the compound disclosed in the invention shows obvious anti-edema activity.

Nickel-catalyzed deallylation of aryl allyl ethers with hydrosilanes

An efficient and mild catalytic deallylation method of aryl allyl ethers is developed, with commercially available Ni(COD)2 as catalyst precursor, simple substituted bipyridine as ligand and air-stable hydrosilanes. The process is compatible with a variety of functional groups and the desired phenol products can be obtained with excellent yields and selectivity. Besides, by detection or isolation of key intermediates, mechanism studies confirm that the deallylation undergoes η3-allylnickel intermediate pathway.

NovelN-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

A novel universalN-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides fromN-terminal dipeptides (32 examples, up to 91%).

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF

Novel TRF1 modulators and analogues thereof. There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell cancer like glioblastoma and lung cancer, and can be also useful for the development of additional TRF1 inhibitors and increasing knowledge about TRF1 activity.

Method for synthesizing tyrosine framework type periodic mesoporous organosilicas materials

The invention relates to a method for preparing tyrosine framework type periodic mesoporous organosilicas materials. The method for synthesizing the tyrosine framework type periodic mesoporous organosilicas materials includes esterifying tyrosine in methanol by the aid of thionyl chloride; carrying out acrylation on the tyrosine by the aid of hydrazine hydrate and carrying out reaction on the tyrosine and isocyanic acid propyltriethoxysilane to obtain tyrosine organosilicas precursors; hydrolyzing the tyrosine organosilicas precursors and surfactants under acidic conditions to form PMO (periodic mesoporous organosilicas) materials; removing the surfactants from the PMO materials by means of extraction to ultimately form PMO materials with specific morphological structures. The tyrosine is used as a substrate. The methanol is used as a solvent. The method has the advantages synthesis reaction raw materials are simple and are easily available, synthesis operation is simple and convenient and is easy to implement, and the method is high in yield and low in energy consumption and is safe and inexpensive; the tyrosine framework type periodic mesoporous organosilicas materials prepared by the aid of the method have important application prospects in the fields of biosensors, catalyst carriers, adsorbents, sustained-release medicine capsules, chromatographic separation and the like.

Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus

A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established.

A PRODUCING METHOD OF D-FORM OR L-FORM AMINO ACID DERIVATIVES HAVING A THIOL GROUP

This invention provides a producing method of an optical active D-form and/or L-form amino acid having a thiol group on its side chain by a simple method with good yield. This invention provides a producing method of an amino acid derivative having a thiol group on its side chain, and an intermediate thereof, wherein the producing method is characterized by producing an intermediate composition comprising a D-form and L-form of amino acid derivate having a thiol group at β -position, reacting D- or L-amino acid selective hydrolytic enzyme, and isolating the hydrolyzed D- or L-amino acid derivative.

Iron-catalyzed oxidative C - H/C - H cross-coupling: An efficient route to α-quaternary α-amino acid derivatives

Fully loaded: A coordinating activation strategy has been developed to furnish α-quaternary α-amino acids through the iron(III)-catalyzed oxidative functionalization of α-C(sp3) - H bonds of α-tertiary α-amino acid esters. The reaction exhibits a broad substrate scope for both α-amino acids and nucleophiles (Nu) as well as good functional-group tolerance (see scheme, DTBP=di-tert-butyl peroxide, DCE=1,2-dichloroethane). Copyright

Enzymatic synthesis of chiral phenylalanine derivatives by a dynamic kinetic resolution of corresponding amide and nitrile substrates with a multi-enzyme system

Mutant α-amino-ε-caprolactam (ACL) racemase (L19V/L78T) from Achromobacter obae with improved substrate specificity toward phenylalaninamide was obtained by directed evolution. The mutant ACL racemase and thermostable mutant D-amino acid amidase (DaaA) from Ochrobactrum anthropi SV3 co-expressed in Escherichia coli (pACLmut/pDBFB40) were utilized for synthesis of (R)-phenylalanine and non-natural (R)-phenylalanine derivatives (4-OH, 4-F, 3-F, and 2-F-Phe) by dynamic kinetic resolution (DKR). Recombinant E. coli with DaaA and mutant ACL racemase genes catalyzed the synthesis of (R)-phenylalanine with 84% yield and 99% ee from (RS)-phenylalaninamide (400 mM) in 22 h. (R)-Tyrosine and 4-fluoro-(R)-phenylalanine were also efficiently synthesized from the corresponding amide compounds. We also co-expresed two genes encoding mutant ACL racemase and L-amino acid amidase from Brevundimonas diminuta in E. coli and performed the efficient production of various (S)-phenylalanine derivatives. Moreover, 2-aminophenylpropionitrile was converted to (R)-phenylalanine by DKR using a combination of the non-stereoselective nitrile hydratase from recombinamt E. coli and mutant ACL racemase and DaaA from E. coli encoding mutant ACL racemase and DaaA genes. Copyright