68716-49-4

Basic information

• Product Name: 2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE
• Synonyms: 2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE;4-Bromophenylboronic acid,pinacol ester;1,3,2-Dioxaborolane, 2-(4-bromophenyl)-4,4,5,5-tetramethyl-
• CAS NO: 68716-49-4
• Molecular Formula: C₁₂H₁₆BBrO₂
• Molecular Weight: 282.98
• Mol File: 68716-49-4.mol
• Article Data: 88

Chemical Properties

• Melting Point: 69.0 to 73.0 °C
• Boiling Point: 324.147°C at 760 mmHg
• Flash Point: 149.839°C
• Appearance: /
• Density: 1.297g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE(68716-49-4)
• EPA Substance Registry System: 2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE(68716-49-4)

Safety Data

• Hazardous Substances Data: 68716-49-4(Hazardous Substances Data)

Usage

General Description

2-(4-Bromo-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane is a chemical compound with the molecular formula C12H17BO2Br. It is a boronic ester derivative, which contains a boron atom and a bromine atom bonded to a phenyl ring. 2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE is commonly used as a building block in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and materials science. It is a versatile reagent in Suzuki-Miyaura cross-coupling reactions, which are widely used in the construction of carbon-carbon bonds. Overall, 2-(4-Bromo-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane is an important and valuable chemical in the field of organic chemistry.

InChI:InChI=1/C12H16BBrO2/c1-11(2)12(3,4)16-13(15-11)9-5-7-10(14)8-6-9/h5-8H,1-4H3

Upstream product

• 589-87-7 1,4-bromoiodobenzene 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 106-37-6 1.4-dibromobenzene 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 4250-49-1 (4-bromophenyl)dichloroborane 
• 108-86-1 bromobenzene 
• 1359224-18-2 Me₂NTol*BCl₃ 
• 1350843-22-9 lutidine 
• 2890-88-2 (C₂H₅)3N*BCl₃ 
• 73183-34-3 bis(pinacol)diborane 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 34176-08-4 sodium 4-bromobenzenesulfinate 

Downstream Products

• 99770-93-1 benzene-1,4-diboronic acid bispinacol ester 
• 852204-67-2 dimethyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]phosphonate 
• 1220095-36-2 N-pentyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1240816-11-8 (R)-2-[1-(4-bromophenyl)-1-phenylpropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1262045-06-6 [Rh(trispyridylmethylamine)(CH₂CH₂OB(OC(CH₃)2)2)(4-Br-C₆H₄)]PF₆ 
• 1269230-74-1 3,3-bis(4-bromophenyl)-5,5,6,6-tetramethyl-2-(trimethylsiloxy)-1,4,2-dioxaborinane 
• 1335316-49-8 tert-butyl (2S,4S)-2-[5-(4-bromophenyl)-1H-benzimidazol-2-yl]-4-methyl-pyrrolidine-1-carboxylate 
• 1613405-40-5 (R)-2-(1-(4-bromophenyl)-1-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1883793-85-8 C₁₇H₂₅BO₄ 
• 820223-94-7 4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl))phenylcyclohexane 

Relevant articles and documents

Unreactive C-N Bond Activation of Anilines via Photoinduced Aerobic Borylation

Unreactive C-N bond activation of anilines was achieved by photoinduced aerobic borylation. A diverse range of tertiary and secondary anilines were converted to aryl boronate esters in moderate to good yields with wide functional group tolerance under simple and ambient photochemical conditions. This transformation achieved the direct and facile C-N bond activation of unreactive anilines, providing a convenient and practical route transforming widely available anilines into useful aryl boronate esters.

Synthesis of arylboronates via the Pd-catalyzed desulfitative coupling reaction of sodium arylsulfinates with bis(pinacolato)diboron

The desulfitative borylation reaction of sodium arylsulfinates with bis(pinacolato)diboron or bis(neopentylglycolato)diboron under palladium catalysis has been developed, allowing selective C-B bond formation to give arylboronates with a range of functional groups in moderate to good yields under mild reaction conditions. A gram-scale preparation as well as the cascade Suzuki-Miyaura cross-coupling of arylboronates demonstrated the potential practical utility in organic synthesis.

Evaluation of the role of graphene-based Cu(i) catalysts in borylation reactions

Carbon-supported catalysts have been considered as macromolecular ligands which modulate the activity of the metallic catalytic center. Understanding the properties and the factors that control the interactions between the metal and support allows a fine tuning of the catalyzed processes. Although huge effort has been devoted to comprehending binding energies and charge transfer for single atom noble metals, the interaction of graphenic surfaces with cheap and versatile Cu(i) salts has been scarcely studied. A methodical experimental and theoretical analysis of different carbon-based Cu(i) materials in the context of the development of an efficient, general, scalable, and sustainable borylation reaction of aliphatic and aromatic halides has been performed. We have also examined the effect of microwave (MW) radiation in the preparation of these type of materials using sustainable graphite nanoplatelets (GNP) as a support. A detailed analysis of all the possible species in solution revealed that the catalysis is mainly due to an interesting synergetic Cu2O/graphene performance, which has been corroborated by an extensive theoretical study. We demonstrated through DFT calculations at a high level of theory that graphene enhances the reactivity of the metal in Cu2O against the halide derivative favoring a radical departure from the halogen. Moreover, this material is able to stabilize radical intermediates providing unexpected pathways not observed using homogeneous Cu(i) catalysed reactions. Finally, we proved that other common carbon-based supports like carbon black, graphene oxide and reduced graphene oxide provided poorer results in the borylation process.