69573-75-7Relevant articles and documents
5-Fluorouracil derivatives
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, (2008/06/13)
5-Fluorouracil derivatives and a process for their preparation are provided. The 5-fluorouracil derivatives according to the invention have the general formula: STR1 R1 and R2 are the same or different and are hydrogen or STR2 with the proviso that both R1 and R2 are not hydrogen at the same time. A1, A2 and A3 are independently selected from hydrogen, and optionally substituted alkoxy and phenyloxy; at least one of A1, A2 and A3 being other than hydrogen. The 5-fluorouracil derivative is prepared by condensing 5-fluorouracil with a halide of the formula: STR3 in the presence of a base. The 5-fluorouracils according to the invention show anti-tumor activity.