115-20-8

Basic information

• Product Name: Trichloroethanol
• Synonyms: (Hydroxymethyl)trichloromethane;2,2,2-Trichloro-1-ethanol;2,2,2-trichloro-ethano;2,2,2-Trichloroethyl alcohol;2,2,2-trichloroethylalcohol;beta,beta,.beta-Trichloroethanol;beta,beta,beta-trichloroethanol;CCl3CH2OH
• CAS NO: 115-20-8
• Molecular Formula: C₂H₃Cl₃O
• Molecular Weight: 149.4
• EINECS: 204-071-0
• Product Categories: Miscellaneous
• Mol File: 115-20-8.mol
• Article Data: 32

Chemical Properties

• Melting Point: 17.8 °C(lit.)
• Boiling Point: 152-154 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.56 g/mL at 20 °C(lit.)
• Vapor Density: 5.16 (vs air)
• Vapor Pressure: 1 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.49(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: 83g/l
• PKA: 12.24(at 25℃)
• Water Solubility: Slightly soluble in water.
• Sensitive: Hygroscopic
• Merck: 14,9638
• BRN: 1697495
• CAS DataBase Reference: Trichloroethanol(CAS DataBase Reference)
• NIST Chemistry Reference: Trichloroethanol(115-20-8)
• EPA Substance Registry System: Trichloroethanol(115-20-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41-67
• Safety Statements: 26-39
• RIDADR: 1760
• WGK Germany: 1
• RTECS: KM3850000
• F: 3-21
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 115-20-8(Hazardous Substances Data)

Usage

Chemical Description

Trichloroethanol is a colorless liquid with a chloroform-like odor, while triethyl orthoformate is a clear, colorless liquid with a pungent odor.

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

Different sources of media describe the Uses of 115-20-8 differently. You can refer to the following data:
1. Intermediate, anesthetic.
2. 2,2,2-Trichloroethanol (TCE) is an active metabolite of Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] (T774055), a sedative/hypnotic that increases cerebral blood flow (CBF).
3. The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.Some of its other application include:Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.Preparation of TCE ester of chlorosulfuric acid.Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andrectal routes. Human mutation data reported. Explosivereaction with concentrated sodium hydroxide solutions.When heated to decomposition it emits toxic fumes ofClí. Us

InChI:InChI=1/C2H3Cl3O/c3-1-2(4,5)6/h6H,1H2

Upstream product

• 515-84-4 Ethyl trichloroacetate 
• 76-02-8 trifluoroacetyl chloride 
• 50-00-0 formaldehyd 
• 67-66-3 chloroform 
• 19468-97-4 α,α-dichloroethyl radical 
• 23273-89-4 1,1,1-trichloroethyl radical 
• 29817-35-4 1-acetyl-2-methylhydrazine 
• 1118-44-1 1,1,1-trichloro-2-cyanato-ethane 
• 1199-86-6 N-(phenylacetyl)-N'-methylhydrazine 
• 1215-52-7 N-benzoyl-N'-benzylhydrazine 
• 75-87-6 chloral 
• 108-93-0 cyclohexanol 
• 79-01-6 Trichloroethylene 
• 76-01-7 pentachloroethane 

Downstream Products

• 107-69-7 Voluntal 
• 97631-94-2 2-chloro-benzoic acid-(2,2,2-trichloro-ethyl ester) 
• 126336-29-6 4-methoxy-benzoic acid-(2,2,2-trichloro-ethyl ester) 
• 19361-93-4 4-chloro-benzenesulfonic acid-(2,2,2-trichloro-ethyl ester) 
• 28394-59-4 3,4-dichloro-benzoic acid-(2,2,2-trichloro-ethyl ester) 
• 37934-99-9 2,2,2-trichloroethyl benzoate 
• 632-50-8 1,1,2,2-tetraphenylethane 
• 6093-25-0 3,5-dinitro-benzoic acid-(2,2,2-trichloro-ethyl ester) 
• 58159-62-9 1-methyl-2,4,6-triphenyl-1-(2,2,2-trichloro-ethoxy)-1λ⁵-phosphinine 
• 69573-75-7 chloromethyl-(2,2,2-trichloroethyl)-ether 
• 6263-69-0 Di-(2,2,2-trichlor-ethoxy)-methan 
• 46825-82-5 o-Hydroxyphenyl-2,2,2-trichlorethylphosphat 
• 52451-89-5 6-Methyl-2-oxo-4-(2,2,2-trichloro-ethoxy)-cyclohex-3-enecarboxylic acid ethyl ester 
• 37150-42-8 [Ethoxy-(2,2,2-trichloro-ethoxy)-methyl]-benzene 

Related news

Short communicationInhibition by chloral hydrate and Trichloroethanol (cas 115-20-8) of AMPA-induced Ca2+ influx in rat cultured cortical neurones08/31/2019

The effects of chloral hydrate and its main metabolite 2,2,2-trichloroethanol were investigated on the (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-induced rise of intracellular Ca2+ concentration ([Ca2+]i) in cultured non-pyramidal cortical neurones of rats by using single-cell ...detailed

Trichloroethanol (cas 115-20-8) up-regulates matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in HaCaT cells08/27/2019

Occupational trichloroethylene (TCE) exposure could induce generalized skin hypersensitivity reactions complicated with severe liver dysfunctions. Active extracellular matrix degradation and remodeling are involved in the skin hypersensitivity reaction induced by chemical exposure. In the presen...detailed

Trichloroethanol (cas 115-20-8) enhances the activity of recombinant human TREK-1 and TRAAK channels08/26/2019

Human TREK-1 and TRAAK (hTREK-1 and hTRAAK) are the recently cloned tandem pore-domain potassium channels that are highly expressed in the central nervous system (CNS). The roles of 2P domain K+ channels in general anesthesia and neuroprotection have been proposed recently. We have investigated ...detailed

Trichloroethylene oxidative metabolism in plants: the Trichloroethanol (cas 115-20-8) pathway08/22/2019

Trichloroethylene (TCE) is a widespread and persistent environmental contaminant. Recently, plants, poplar trees in particular, have been investigated as a tool to remove TCE from soil and groundwater. The metabolism of TCE in plants is being investigated for two reasons: one, plant uptake and m...detailed

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