710943-26-3

Basic information

• Product Name: 6-AMINOMETHYL INDAZOLE
• Synonyms: 6-AMINOMETHYL INDAZOLE;6-aminomethyl-1H-indazole;(1H-indazol-6-yl)methanamine;1-(1H-indazol-6-yl)methanamine;(1H-Indazol-6-yl)methylamine;C-(1H-Indazol-6-yl)-methylamine
• CAS NO: 710943-26-3
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• Product Categories: Building Blocks;Indazole
• Mol File: 710943-26-3.mol

Chemical Properties

• Boiling Point: 352.1 °C at 760 mmHg
• Flash Point: 193.8 °C
• Appearance: /
• Density: 1.278 g/cm³
• Vapor Pressure: 3.93E-05mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.27±0.40(Predicted)
• CAS DataBase Reference: 6-AMINOMETHYL INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINOMETHYL INDAZOLE(710943-26-3)
• EPA Substance Registry System: 6-AMINOMETHYL INDAZOLE(710943-26-3)

Safety Data

• RIDADR: UN3439
• Hazardous Substances Data: 710943-26-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Aminomethyl Indazole is used as an intermediate chemical for the synthesis of various pharmaceuticals. Its indazole group is a common structure in many bioactive molecules, making it an essential component in the development of new drugs.
Used in Scientific Research:
6-Aminomethyl Indazole is used as a research compound to study the properties and potential applications of indazole-containing molecules. This helps in understanding the role of such structures in biological systems and their potential for therapeutic use.
Used in Drug Development:
6-Aminomethyl Indazole is used as a key component in the synthesis of novel biologically active compounds. Its presence in many bioactive molecules makes it a valuable asset in the development of new drugs with potential therapeutic applications.

InChI:InChI=1/C8H9N3/c9-4-6-1-2-7-5-10-11-8(7)3-6/h1-3,5H,4,9H2,(H,10,11)

Upstream product

• 141290-59-7 1H-indazole-6-carbonitrile 

Downstream Products

• 1612182-03-2 6-(2,3-dimethylphenyl)-4-N-(1H-indazol-6-ylmethyl)pyrimidine-2,4-diamine 

Relevant articles and documents

Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases

Nitric oxide (NO) is an essential endogenous mediator with a physiological role in the central nervous system as neurotransmitter and neuromodulator. A growing number of studies have demonstrated that abnormal nitrergic signaling is a crucial event in the development of neurodegeneration. In particular, the uncontrolled production of NO by neuronal nitric oxide synthase (nNOS) is observed in several neurodegenerative diseases. Moreover, it is well recognized that specific isoforms of human carbonic anhydrase (hCA) physiologically modulate crucial pathways of signal processing and that low expression of CA affects cognition, leading to mental retardation, Alzheimer′s disease, and aging-related cognitive impairments. In light of this, dual agents that are able to target both NOS (inhibition) and CA (activation) could be useful drug candidates for the treatment of Alzheimer′s disease, aging, and other neurodegenerative diseases. In the present work, we show the design, synthesis, and in vitro biological evaluation of new nitrogen-based heterocyclic compounds. Among the tested molecules, 2-amino-3-(4-hydroxyphenyl)-N-(1H-indazol-5-yl)propanamide hydrochloride (10 b) was revealed to be a potent dual agent, able to act as a selective nNOS inhibitor and activator of the hCA I isoform.

MODULATORS OF CELLULAR ADHESION

The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).