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714218-67-4

3-amino-6-bromo-N-(2-methoxyethyl)pyrazine-2-carboxamide is a complex organic compound with the molecular formula C8H11BrN4O3. It features a pyrazine-2-carboxamide core, which is a heterocyclic structure with two nitrogen atoms in a six-membered ring. The compound is characterized by the presence of a bromine atom at the 6-position, an amino group at the 3-position, and a 2-methoxyethyl group attached to the nitrogen atom. This molecule is of interest in the field of medicinal chemistry and may have potential applications in the development of pharmaceuticals due to its unique structure and functional groups.

714218-67-4

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714218-67-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 714218-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,1,4,2,1 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 714218-67:
(8*7)+(7*1)+(6*4)+(5*2)+(4*1)+(3*8)+(2*6)+(1*7)=144
144 % 10 = 4
So 714218-67-4 is a valid CAS Registry Number.

714218-67-4Relevant articles and documents

Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimers Disease: Design, synthesis, and characterization of pyrazines

Berg, Stefan,Bergh, Margareta,Hellberg, Sven,Hoegdin, Katharina,Lo-Alfredsson, Yvonne,Soederman, Peter,Von Berg, Stefan,Weigelt, Tatjana,Ormoe, Mats,Xue, Yafeng,Tucker, Julie,Neelissen, Jan,Jerning, Eva,Nilsson, Yvonne,Bhat, Ratan

supporting information, p. 9107 - 9119,13 (2020/10/15)

Glycogen synthase kinase-3β, also called tau phosphorylating kinase, is a proline-directed serine/threonine kinase which was originally identified due to its role in glycogen metabolism. Active forms of GSK3β localize to pretangle pathology including dystrophic neuritis and neurofibrillary tangles in Alzheimers disease (AD) brain. By using a high throughput screening (HTS) approach to search for new chemical series and cocrystallization of key analogues to guide the optimization and synthesis of our pyrazine series, we have developed highly potent and selective inhibitors showing cellular efficacy and bloo-brain barrier penetrance. The inhibitors are suitable for in vivo efficacy testing and may serve as a new treatment strategy for Alzheimers disease.

NOBEL COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3

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Page 36, (2008/06/13)

The present invention relates to new compounds of formula (I) wherein Z is N; Y is CONR5, NR5CO, SO2NR5, NR5SO2, CH2NR5, NR5, NR5CONR5

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