486424-37-7

Basic information

• Product Name: 3-Amino-6-bromopyrazine-2-carboxylic acid
• Synonyms: 3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID, 95+%;3-AMINO-6-BROMOPYRAZINE-2-CARB;3-AMino-6-broMo-2-pyrazinecarboxylic Acid;2-Amino-5-bromo-3-carboxypyrazine, 2-Amino-5-bromo-3-carboxy-1,4-diazine
• CAS NO: 486424-37-7
• Molecular Formula: C₅H₄BrN₃O₂
• Molecular Weight: 218.01
• EINECS: 1312995-182-4
• Product Categories: Bases & Related Reagents;Nucleotides
• Mol File: 486424-37-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 178-183℃
• Boiling Point: 397.76 °C at 760 mmHg
• Flash Point: 194.359 °C
• Appearance: Pale yellow/Solid
• Density: 2.04 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.7
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: Soluble in dimethyl sulfoxide and methanol.
• PKA: 3.26±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-Amino-6-bromopyrazine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-6-bromopyrazine-2-carboxylic acid(486424-37-7)
• EPA Substance Registry System: 3-Amino-6-bromopyrazine-2-carboxylic acid(486424-37-7)

Safety Data

• Hazardous Substances Data: 486424-37-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

3-Amino-6-bromopyrazine-2-carboxylic acid used to prepare 3-bromo-5-phenylpyrazine-2-amine. It serves as an intermediate in organic synthesis and pharmaceuticals.

InChI:InChI=1/C5H4BrN3O2/c6-2-1-8-4(7)3(9-2)5(10)11/h1H,(H2,7,8)(H,10,11)

Upstream product

• 5424-01-1 3-aminopyrazinoic acid 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 6966-01-4 methyl 3-amino-6-bromopyrazine-2-carboxylate 

Downstream Products

• 1373042-89-7 C₁₇H₂₂N₆O₃S 
• 1466564-87-3 C₂₆H₂₅ClN₆O₅S 
• 1466564-85-1 C₂₄H₂₃ClN₆O₄S 
• 6966-01-4 methyl 3-amino-6-bromopyrazine-2-carboxylate 
• 714218-67-4 3-amino-6-bromo-N-(2-methoxyethyl)pyrazine-2-carboxamide 
• 714218-76-5 3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride 
• 714237-32-8 3-amino-N-(3-methoxyphenyl)-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-2-pyrazinecarboxamide hydrochloride 
• 1373042-91-1 C₁₉H₂₆N₆O₃S 
• 1373042-90-0 C₁₈H₂₄N₆O₃S 
• 1373042-92-2 C₁₇H₂₂N₆O₃S 
• 1373042-97-7 C₂₂H₂₇N₅O₃S 
• 1373042-94-4 C₂₀H₂₈N₆O₃S 

Relevant articles and documents

Synthesis method of 2-amino-3, 5-dihalogenated pyrazine

The invention relates to a synthesis method of 2-amino-3, 5-dihalogenated pyrazine, and the synthesis route is shown in the specification. In the formula, X1 is Cl, Br or I; X2 is Cl, Br or I; and X1 and X2 are different, a first halogen source provides X1, and a second halogen source provides X2. The synthesis method disclosed by the invention can be suitable for all types of 2-amino-3, 5-dihalogenated pyrazine except for fluorinated pyrazine. According to the method, the reaction conditions are mild, all reactions can be completed at the temperature of 80 DEG C or below and under the normal pressure condition, and special equipment is not needed; and the method has the advantages of high reaction yield, stable amplification yield, simple post-treatment, economy and convenience.

INHIBITING ATAXIA TELANGIECTASIA AND RAD3-RELATED PROTEIN (ATR)

Novel compounds inhibiting ATR protein kinase include compounds of formula (I) disclosed herein, as well as liposome formulations comprising ATR protein kinase inhibitor compounds. The compositions are useful for the treatment of cancer.

SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

Disclosed are compounds of formula (I) that are useful as hepatitis C virus (HCV) NSSB polymerise inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NSSB polymerise activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.