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Cas Database

7146-67-0

7146-67-0

Identification

  • Product Name:Benzenesulfonamide,N,N-bis(2-hydroxyethyl)-4-methyl-

  • CAS Number: 7146-67-0

  • EINECS:230-455-2

  • Molecular Weight:259.326

  • Molecular Formula: C11H17NO4S

  • HS Code:2935009090

  • Mol File:7146-67-0.mol

Synonyms:p-Toluenesulfonamide,N,N-bis(2-hydroxyethyl)- (6CI,7CI,8CI);(p-Tolylsulfonyl)diethanolamine;N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide;N,N-Bis(2-hydroxyethyl)-p-toluenesulfonamide;NSC 23811;NSC 46865;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Hydroxy-N-(2-hydroxyethyl)-S-(4-methylphenyl)ethane-1-sulfonamido
  • Packaging:1g
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:N,N-Bis(2-hydroxyethyl)-p-toluenesulfonamide >97.0%(HPLC)
  • Packaging:25g
  • Price:$ 132
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide 95+%
  • Packaging:500g
  • Price:$ 653
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide 95%
  • Packaging:500g
  • Price:$ 611
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:N,N-BIS-(2-HYDROXYETHYL)-P-TOLUENESULFONAMIDE 95.00%
  • Packaging:1G
  • Price:$ 638.1
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide
  • Packaging:500g
  • Price:$ 672.59
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide
  • Packaging:25g
  • Price:$ 226
  • Delivery:In stock
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Relevant articles and documentsAll total 13 Articles be found

Impact of N-substituents on crystal packing of N-alkyl-N′-tosylpiperazines and development of new polymorph of tosylbis(2-(tosyloxy)ethyl)amine: Synthesis, DFT, photophysical, cytotoxic property

Kadu, Rahul,Savani, Chirag,Roy, Hetal,Soni,Singh, Atresh Kumar,Vennapu, Dushyanth R.,Singh, Vinay K.

, (2020/11/25)

Diethanol amine (DEA) was selected as a lead compound to prepare N-tosyldiethanol amine 1, N-tosylbis(2-(tosyloxy)ethyl)amine 2 and disubstituted piperazines ca N-alkyl-N′-tosylpiperazines 3–5 in high yield. The new compounds were characterized by using relevant techniques viz. MS, IR, 1H, 13C, DEPT 135 NMR, UV–vis. absorption and fluorescence spectral studies. Single crystal X-ray diffraction technique was used to detect a new polymorphic form of 2 and to measure the influence of various N-substituents on the association of molecules of 3–5 in the solid state. Evidently, the introduction of N-cyclohexyl substituent in 3 successfully switches off all the synthons ca CH…O and CH…N seen in compound 4 and 5. Compounds 4 and 5 holding N-furfuryl and N-benzyl substituents, respectively, adopt other packing strategies based on CH…O, CH…N (4) and CH…O (5) interactions. The antitumor activity of 1–5 was evaluated in vitro against Hep 3B and IMR 32 by the MTT assay and the results were compared with cisplatin. Remarkably, some compounds were found extremely active against both the cell lines and proved to be more potent as cytotoxic agents than cisplatin. Density functional theory and molecular docking studies have been performed to rationalize the experimental results.

Transition metal- And catalyst-free one-pot green method for the synthesis of: N -sulfonyl amidines via direct reaction of sulfonyl azides with amines

Aoyama, Hiroshi,Kaboudin, Babak,Kazemi, Foad,Torabi, Saeed

, p. 26701 - 26708 (2020/08/19)

In this report, a green synthesis of N-sulfonyl amidines via the direct reaction of tertiary or secondary amines with sulfonyl azides is described. Transition metal- and catalyst-free conditions were used for the synthesis of biologically important N-sulfonyl amidines. Further studies showed that the reaction proceeded via in situ aerobic oxidation of amines under reflux conditions.

NOVEL CYTOTOXIC AGENTS AND CONJUGATES THEREOF

-

Page/Page column 97, (2018/04/13)

Provided herein are novel maytansinoid compounds of general formula I. Also provided herein are conjugates comprising the compounds linked to a binding protein via a linker, and conjugating reagents comprising the compounds attached via a linker to at least one functional group capable of reacting with a binding protein. Also provided herein are pharmaceutical compositions comprising the compounds and conjugates, therapeutic methods and uses involving the compounds and conjugates, for example in cancer therapy, and novel synthetic processes.

CONJUGATES AND CONJUGATING REAGENTS COMPRISING A LINKER THAT INCLUDES AT LEAST TWO (-CH2-CH2-0-) UNITS IN A RING

-

Page/Page column 44, (2017/11/16)

A conjugate comprising a protein or peptide conjugated to a therapeutic, diagnostic or labelling agent via a linker, characterised in that the linker includes at least two ~(CH2-CH2- 0-)~ units within a ring, said ring being attached via a single tethering atom within the ring to the rest of the linker, or said ring being attached via two or more tethering atoms within the ring to the rest of the linker at a single point.

Synthesis, biological evaluation and study of the effect of various N-substituents on the thermal stabilities of some new diethanolamine derivatives

Yar, Muhammad,Mushtaq, Nafeesa,Afzal, Sadia,Khan, Abdul Samad,Khan, Islam Ullah,Akhter, Muhammad Nadeem,Zareen, Seema,Shahzad, Sohail Anjum,Khan, Zulfiqar Ali,Raza Naqvi, Syed Ali,Mahmood, Nasir,Tahir, Lubna,Saleem, Muhammad

, p. 7297 - 7304 (2013/08/23)

Diethanolamine and its derivatives are of considerable interest in medicinal and other industrial products. A series of new diethanolamine derivatives has been synthesized and characterized by 1H NMR, 13C NMR, FTIR and mass spectrometry. All synthesized compounds have been tested for their in vitro antibacterial activity against pathogenic microorganisms Escherichia coli, Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa, Bacillus subtilis, Pasteurrella mutocida, Rhizopus oryzae and Salmonella typhi. Among the tested compounds, compounds 2a, 2b, 2c, 3a and 4b have been found to be most potent members, which inhibited most of the pathogens used in the assay. Diethanolamine must posses tosyl or trifluoro groups in order to have good antimicrobial activities. All synthesized derivatives exhibited average FRAP activity and considerably good metal chelating activity and compound 2c showed excellent ABTS radical scavanging among all tested derivatives. Thermal stability and the effect of various N-protected groups on the thermal stability and degradation of selected diethanolamine derivatives (free flowing oils at room temperature and solid derivative 2a) has been studied by TGA and DSC analysis.

Process route upstream and downstream products

Process route

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
With triethylamine; In dichloromethane; at 20 ℃; for 4h;
90%
With sodium carbonate; at 95 ℃; for 1h;
86%
With sodium carbonate; In water; at 95 ℃; for 1h;
85%
With potassium carbonate; In water; at 100 ℃; for 1h;
80%
With triethylamine; In toluene; at 5 - 10 ℃;
80%
With potassium carbonate; In water; at 100 ℃; for 1h;
63%
With sodium carbonate;
With triethylamine; In dichloromethane; at 20 ℃; for 2h;
4.7 g
With triethylamine; In dichloromethane; at 20 ℃; for 2h;
4.7 g
With potassium carbonate; triethylamine; In dichloromethane; Inert atmosphere;
N,N-Bis[2-(tetrahydropyran-2-yloxy)ethyl]toluene-p-sulfonamide
292824-79-4

N,N-Bis[2-(tetrahydropyran-2-yloxy)ethyl]toluene-p-sulfonamide

N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
With Amberlist-15; In methanol; at 20 ℃; for 12h;
82%
4-toluenesulfonyl azide
941-55-9

4-toluenesulfonyl azide

triethanolamine
102-71-6,64114-46-1

triethanolamine

N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
In 1,4-dioxane; at 110 ℃; for 24h; Green chemistry;
46%
toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
With sodium hydroxide; benzene;
toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

2-chloro-ethanol
107-07-3

2-chloro-ethanol

N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
With sodium hydroxide;
2-chloro-ethanol
107-07-3

2-chloro-ethanol

N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
at 120 ℃;
N,N-bis(tosyloxyethyl)-p-toluenesulfonamide
16695-22-0

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide

N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

Conditions
Conditions Yield
2,2'-Dihydroxy-diethylamin <2Mol>, p-Toluolsulfochlorid <1Mol> ;
(yield)90percent;
p-Toluol-sulfochlorid, Diethanolamin, wss.Na2CO3 <100grad>;
Diaethanolamin(1), p-Toluolsulfonylchlorid(2);
N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

N,N-bis(2-chloroethyl)-p-toluenesulfonamide
42137-88-2

N,N-bis(2-chloroethyl)-p-toluenesulfonamide

Conditions
Conditions Yield
With thionyl chloride; at 110 ℃; for 1h;
84%
With thionyl chloride;
With thionyl chloride; In dichloromethane;
N-tosyldiethanolamine
7146-67-0

N-tosyldiethanolamine

N-(p-tosyl)-4-phenyl-4-cyano-piperidine
24476-55-9

N-(p-tosyl)-4-phenyl-4-cyano-piperidine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 84 percent / thionyl chloride / 1 h / 110 °C
2: 80 percent / NaNH2 / toluene / 1 h / Heating
With thionyl chloride; sodium amide; In toluene;

Global suppliers and manufacturers

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  • Amadis Chemical Co., Ltd.
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  • GIHI CHEMICALS CO.,LIMITED
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  • Finetech Industry Limited
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  • Antimex Chemical Limied
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  • Skyrun Industrial Co.,Ltd
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  • Debye Scientific
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  • Bide Pharmatech Ltd
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