7149-10-2Relevant articles and documents
Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines
Chen, Lina,Ding, Yingying,Jiao, Qingcai,Liu, Junzhong,Yu, Jinhai,Zhang, Hongjuan,Zong, Weilu
, (2021/11/05)
In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.
Efficient hydrogenation of benzaldoximes and Schiff bases on ceramic high-porosity palladium catalysts
Ignatov,Varakutin,Solov’eva,Karmanova,Kozlov,Semenova,Semenov
, p. 1394 - 1400 (2018/10/31)
An efficient catalytic method for the synthesis of benzyl- and dibenzylamines by hydrogenating oximes and Schiffbases was developed on palladium supported high-porosity foamed ceramic block catalyst. The multiple regeneration ability of the foamed ceramic block catalyst can significantly decrease the Pd consumption as compared to the use of the conventional 10%Pd/C catalyst. Owing to a high hardness of the foamed ceramic catalyst, the reaction mixture can rapidly be removed from the reactor without using filtering devices. The structures produced by the reaction are fragments of biologically active and natural molecules. Antiproliferative properties of dibenzylamines revealed on the sea urchin embryo model suggest that these compounds can be considered as promising agents for the design of new anticancer drugs.
A capsaicin preparation method
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Paragraph 0029; 0030; 0032; 0033, (2017/08/25)
The invention discloses a preparation method of capsaicine. The method takes vanillin as a raw material, and comprises the steps of: carrying out reaction in an ammonia-gas-containing methanol solution; carrying out hydrogenation reduction by sodium borohydride; carrying out hydrochlorination on the vanillin amine collected from the reaction product; adding the intermediate vanillin amine hydrochloride into a dimethyl formamide (DMF) solvent, and dissolving; and adding nonoic acid, triethylamine and a condensing agent HBTU into the solution, and carrying out condensation reaction to obtain the target product capsaicine. The detection proves that the purity reaches up to more than 98%, and the total yield is 72.1%-81.1%. The preparation method is mild in reaction conditions, high in controllability of the operation process, low in cost and good in purity; a thin layer chromatography (TLC) detection method is used for controlling the reaction process, so that the obtained target product capsaicine is stable in quality and suitable for industrial production.