72324-23-3

Basic information

• Product Name: (4-hydroxy-3-methylphenyl)(4-methoxyphenyl)methanone
• Synonyms: (4-hydroxy-3-methylphenyl)(4-methoxyphenyl)methanone
• CAS NO: 72324-23-3
• Molecular Weight: 242.274
• Mol File: 72324-23-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-hydroxy-3-methylphenyl)(4-methoxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-hydroxy-3-methylphenyl)(4-methoxyphenyl)methanone(72324-23-3)
• EPA Substance Registry System: (4-hydroxy-3-methylphenyl)(4-methoxyphenyl)methanone(72324-23-3)

Safety Data

• Hazardous Substances Data: 72324-23-3(Hazardous Substances Data)

Upstream product

• 1016161-79-7 1-bromo-3-methyl-4-triisopropylsilyloxybenzene 
• 2362-12-1 4-Bromo-2-methylphenol 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 95-48-7 ortho-cresol 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 7504-73-6 2-methylphenyl 4-methoxybenzoate 

Downstream Products

• 1150104-96-3 C₂₂H₂₇NO₃ 
• 115057-30-2 {4-[[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-(4-methoxy-phenyl)-methyl]-2-methyl-phenoxy}-acetic acid 
• 115057-35-7 <4-<(4-methoxyphenyl)methyl>-2-methylphenoxy>acetic acid 
• 115057-32-4 methyl 4-(4'-methoxybenzoyl)-2-methylphenoxyacetate 

Relevant articles and documents

Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis

Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl,gem-dimethyl and carbonyl groups has been demonstrated to often improve chemical properties of target molecules for drug discovery purposes. The investigation of the properties of 3,3-diaryloxetanes, particularly of interest as a benzophenone replacement, remains largely unexplored. With recent synthetic advances in accessing this motif we studied the effects of 3,3-diaryloxetanes on the physicochemical properties of ‘drug-like’ molecules. Here, we describe our efforts in the design and synthesis of a range of drug-like compounds for matched molecular pair analysis to investigate the viability of the 3,3-diaryloxetane motif as a replacement group in drug discovery. We conclude that the properties of the diaryloxetanes and ketones are similar, and generally superior to related alkyl linkers, and that diaryloxetanes provide a potentially useful new design element.

Benzophenone-N-ethyl piperidine ether analogues-Synthesis and efficacy as anti-inflammatory agent

A sequence of substituted benzophenone-N-ethyl piperidine ether analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-inflammatory and ulcerogenic activities of the compounds were compared with naproxen, indomethacin, and phenylbutazone. These analogues showed an interesting anti-inflammatory activity in carrageenan-induced foot pad edema assay. In the air-pouch test, some of the analogues reduced the total number of leukocytes of the exudate, which indicates inhibition of prostaglandin production. Side effects of the compounds were examined on gastric mucosa, in the liver and stomach. None of the compounds illustrated significant side effects compared with standard drugs like indomethacin and naproxen.