72605-86-8

Basic information

• Product Name: methyl 2-chlorothiazole-5-carboxylate
• Synonyms: 2-Chloro-thiazole-5-Carbocylic acid methyl ester;2-Chloro-5-thiazolecarboxylic acid methyl ester;2-Chlorothiazole-5-carboxylic acid methyl ester;5-Carbomethoxy-2-chlorothiazole;Methyl 2-chlorothiazole-5-carboxylate 97%;5-Thiazolecarboxylic acid, 2-chloro-, Methyl ester;Methyl 2-chloro-5-thiazolecarboxylate;2-Chloro-5-(methoxycarbonyl)-1,3-thiazole
• CAS NO: 72605-86-8
• Molecular Formula: C₅H₄ClNO₂S
• Molecular Weight: 178
• EINECS: -0
• Mol File: 72605-86-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 271.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.456±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.09±0.10(Predicted)
• CAS DataBase Reference: methyl 2-chlorothiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-chlorothiazole-5-carboxylate(72605-86-8)
• EPA Substance Registry System: methyl 2-chlorothiazole-5-carboxylate(72605-86-8)

Safety Data

• Hazardous Substances Data: 72605-86-8(Hazardous Substances Data)

Usage

General Description

Methyl 2-chlorothiazole-5-carboxylate is a chemical compound with the molecular formula C6H5ClNO2S. It is a white crystalline solid that is mainly used in the pharmaceutical industry as a building block for the synthesis of various bioactive compounds. This chemical is a derivative of thiazole and contains a chlorine atom and a carboxylate group. It is commonly used as an intermediate in the production of drugs and agrochemicals. Its unique structure and reactivity make it a valuable compound in organic synthesis and drug discovery research. However, it is important to handle and store this compound with caution, as it may have adverse effects on human health and the environment if not properly managed.

Upstream product

• 3034-52-4 2-chlorothiazole 
• 79-22-1 methyl chloroformate 
• 726185-57-5 methyl 2-aminothiazole-5-carboxylate hydrochloride 
• 6633-61-0 methyl 2-aminothiazole-5-carboxylate 

Downstream Products

• 1245157-52-1 methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate 
• 1426899-84-4 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester 
• 133972-64-2 methyl 2-phenylaminothiazole-5-carboxylate 
• 726185-68-8 2-piperazin-1-yl-thiazole-5-carboxylic acid methyl ester 

Relevant articles and documents

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor

Biaryl anthranilides are reported as potent and selective full agonists for the high affinity niacin receptor GPR109A. The SAR presented outlines approaches to reduce serum shift and both CYPCYP2C8 and CYP2C9 liabilities, while improving PK and maintainin

Tyrosine kinase inhibitors

The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such

7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid

7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid, useful as an antiallergic agent, and prepared by reaction of 5-methoxyanthranilic acid with methyl 2-chlorothiazole-5-carboxylate, and subsequent hydrolysis, is described.