1426899-84-4

Basic information

• Product Name: 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester
• Synonyms: 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester
• CAS NO: 1426899-84-4
• Molecular Weight: 381.452
• Mol File: 1426899-84-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester(1426899-84-4)
• EPA Substance Registry System: 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester(1426899-84-4)

Safety Data

• Hazardous Substances Data: 1426899-84-4(Hazardous Substances Data)

Upstream product

• 4079-51-0 1-(3-bromophenyl)-2-hydroxyethan-1-one 
• 1426899-76-4 6-bromo-2-o-tolyl-chroman-4-ol 
• 1426899-80-0 2-o-tolyl-chroman-6-ol 
• 72605-86-8 2-chlorothiazole-5-carboxylic acid methyl ester 
• 1426899-77-5 6-bromo-2-o-tolyl-chroman 
• 1426899-74-2 (E)-1-(5-bromo-2-hydroxy-phenyl)-3-o-tolyl-propenone 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 529-20-4 2-methylphenyl aldehyde 
• 1426899-75-3 6-bromo-2-o-tolyl-chroman-4-one 

Downstream Products

• 1426899-70-8 phosphoric acid mono-(2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]amino}ethyl) ester 
• 1426900-45-9 2-(2-o-tolyl-chroman-6-yloxy)thiazole-5-carboxylic acid 
• 1426899-88-8 phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester 
• 1426899-86-6 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide 
• 1426899-85-5 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt 

Relevant articles and documents

Substituted 2 - (chroman - 6 - yloxy) thiazole and use thereof as a medicament

The invention relates to a substitutional-2-(chroman-6-oxyl) thiazole shown as a formula I, wherein Ar, R2, R3 and R4 are defined in claims. The compound shown as the formula I is a sodium-calcium permutoid (NCX) inhibitor, especially a sodium-calcium permutoid subtype 1 (NCX1) inhibitor, and is applicable to treatment of various disorders caused by calcium unbalance in cells, such as arrhythmia, cardiac failure and apoplexy. The invention also relates to a method for preparing the compound shown as the formula I, an application of the compound as the medicine and a medicine composition containing the compound.

SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula (I), in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.

Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals

Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.