7451-47-0

Basic information

• Product Name: ethyl hexylcarbamate
• CAS NO: 7451-47-0
• Molecular Formula: C₉H₁₉NO₂
• Molecular Weight: 173.2527
• Mol File: 7451-47-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 230°C at 760 mmHg
• Flash Point: 92.9°C
• Density: 0.914g/cm³
• Vapor Pressure: 0.0675mmHg at 25°C
• Refractive Index: 1.431
• CAS DataBase Reference: ethyl hexylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl hexylcarbamate(7451-47-0)
• EPA Substance Registry System: ethyl hexylcarbamate(7451-47-0)

Safety Data

• Hazardous Substances Data: 7451-47-0(Hazardous Substances Data)

Usage

General Description

Ethyl hexylcarbamate, also known as EHC, is a chemical compound commonly used as a preservative in personal care products such as lotions, sunscreen, and hair care products. It is also used as a disinfectant in industrial and household products. EHC is known for its antimicrobial and antifungal properties, which help to extend the shelf life of products and prevent the growth of harmful bacteria and fungi. However, it is important to note that EHC has been associated with skin irritation and allergic reactions in some individuals, and there is ongoing research to better understand its potential health effects. As a result, some countries have imposed restrictions on its use in certain products.

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Relevant articles and documents

Redox self-sufficient biocatalyst network for the amination of primary alcohols

Driving the machinery: A biocatalytic redox-neutral cascade for the preparation of terminal primary amines from primary alcohols at the expense of ammonia has been established in a one-pot one-step method (see picture). Applying this artificial biocatalyst network, long-chain 1,ω-alkanediols were converted into diamines, which are building blocks for polymers, in up to 99 % conversion. Copyright

Pd(OAc)2-catalyzed carbonylation of amines

A phosphine-free catalytic system [Pd(OAc)2-Cu(OAc) 2-air] induced a substrate-specific carbonylation of amines in boiling toluene under CO gas (1 atm). Symmetrical N,N′-dialkylureas were obtained by the carbonylation of primary amines. N,N,N′-Trialkylureas were selectively formed by addition of a secondary amine to the above reaction vessel. Secondary amines did not give tetraalkylureas. However, dialkylamines with a phenyl group on their alkyl chains, such as N-monoalkylated benzylic amine or phenethylamine derivatives, underwent a direct aromatic carbonylation to afford five- or six-membered benzolactams. In the carbonylation, the chelation effect or steric repulsion between Pd(II) and the meta-substituent in the ortho-palladation and the ring sizes of cyclopalladation products that were formed prior to carbonylation were found to generate good site selectivity and increase the reaction rate. In contrast, carbonylation of ω- arylalkylamines with a hydroxyl group gave neither ureas nor benzolactams but instead produced 1,3-oxazolidinones smoothly. Hydrochlorides of amines also underwent carbonylation to afford the corresponding amides under the conditions used. This procedure made it possible to prepare ureas of amino acid esters and N-alkylcarbamates in practical yields.

Zinc promoted simple and convenient synthesis of carbamates: An easy access for amino group protection

Synthesis of alkyl, aryl, heterocyclic, carbohydrate and amino acid carbamates is described. The protection of the amino group in the presence of other functionality in amino acids demonstrates the importance of this method.