74572-09-1

Basic information

• Product Name: Benzenemethanol, a-[[(2-hydroxyethyl)amino]methyl]-, (S)-
• CAS NO: 74572-09-1
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Mol File: 74572-09-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-[[(2-hydroxyethyl)amino]methyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-[[(2-hydroxyethyl)amino]methyl]-, (S)-(74572-09-1)
• EPA Substance Registry System: Benzenemethanol, a-[[(2-hydroxyethyl)amino]methyl]-, (S)-(74572-09-1)

Safety Data

• Hazardous Substances Data: 74572-09-1(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 141-43-5 ethanolamine 
• 20780-53-4 (R)-Styrene oxide 
• 20780-54-5 (S)-styrene oxide 

Downstream Products

• 1174144-80-9 toluene-4-sulfonic acid 2-[(2-hydroxy-2-phenylethyl)(toluene-4-sulfonyl)amino]ethyl ester 
• 942123-01-5 (S)-(2-hydroxy-ethyl)-(2-hydroxy-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 23972-41-0 2-phenylmorpholine 
• 74572-15-9 (2S)-2-phenylmorpholine 
• 74572-12-6 (S)-4-(4-methylbenzenesulfonyl)-2-phenylmorpholine 
• 74572-27-3 (S)-4-(1-Oxy-pyridin-2-yl)-2-phenyl-morpholine 
• 1225376-02-2 (R)-2-phenylmorpholine 
• 131203-51-5 5-phenyl-3-(2-hydroxyethyl)oxazolidin-2-one 
• 65329-72-8 1-(2-hydroxy-ethyl)-4-phenyl-imidazolidin-2-one 

Relevant articles and documents

Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles

We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the accumulation of 5,6α-epoxy-cholesterol (5,6α-EC) and 5,6β-epoxy-cholesterol (5,6β-EC). This could be considered a paradox because epoxides are known as alkylating agents with putative carcinogenic properties. We report here that, as opposed to the carcinogen styrene-oxide, neither of the ECs reacted spontaneously with nucleophiles. Under catalytic conditions, 5,6β-EC remains unreactive whereas 5,6α-EC gives cholestan-3β,5 α-diol-6β-substituted compounds. These data showed that 5,6-ECs are stable epoxides and unreactive toward nucleophiles in the absence of a catalyst, which contrasts with the well-known reactivity of aromatic and aliphatic epoxides. These data rule out 5,6-EC acting as spontaneous alkylating agents. In addition, these data support the existence of a stereoselective metabolism of 5,6α-EC. Copyright

POLYCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR

Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treati

COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR

Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein, R1, R2, A, Y, X, Ar1 and Ar2 have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.