74572-15-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-phenylmorpholine is used as a building block for the synthesis of biologically active compounds, leveraging its unique structure to create new pharmaceutical agents with potential therapeutic benefits.
Used in Agrochemical Industry:
(S)-2-phenylmorpholine is utilized as a precursor in the development of agrochemicals, contributing to the creation of effective compounds for agricultural applications.
Used as an Antifungal Agent:
(S)-2-phenylmorpholine is used as an antifungal agent, demonstrating its potential to combat fungal infections, which is crucial in both medical and agricultural settings.
Used as an Antiviral Agent:
(S)-2-phenylmorpholine is employed for its antiviral properties, showing promise in the development of treatments for viral diseases.
Used in Asymmetric Synthesis:
(S)-2-phenylmorpholine is used as a valuable tool in asymmetric synthesis, enabling the production of enantiomerically pure compounds with high selectivity and efficiency, which is essential in creating pharmaceuticals with fewer side effects.
Used in Catalysis:
(S)-2-phenylmorpholine is applied in catalysis processes, where its chiral nature aids in the selective formation of desired enantiomers, enhancing the efficiency and selectivity of chemical reactions.

Upstream product

• 74572-12-6 (S)-4-(4-methylbenzenesulfonyl)-2-phenylmorpholine 
• 1020673-57-7 (S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester 
• 942123-04-8 (S)-6-phenylmorpholin-3-one 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 149495-00-1 (S)-1-phenyl-2-nitroethanol 
• 100-52-7 benzaldehyde 
• 74572-09-1 (S)-2-(2-hydroxy-ethylamino)-1-phenyl-ethanol 
• 20780-54-5 (S)-styrene oxide 

Downstream Products

• 74572-27-3 (S)-4-(1-Oxy-pyridin-2-yl)-2-phenyl-morpholine 
• 1020673-55-5 (S)-4-(4-phenoxy-benzyl)-2-phenyl-morpholine 
• 1020673-59-9 (S)-4-(6-chloropyridin-3-methyl)-2-phenyl-morpholine 

Relevant academic research and scientific papers

Preparation method of chiral morpholine compound

The invention provides a preparation method of a chiral morpholine compound. With chiral ethylene oxide as a raw material, the preparation method comprises the steps of ring opening, cyclization and deprotection reaction to obtain the chiral 2-substituted morpholine compound. The preparation process is simple and environmentally friendly, has mild reaction conditions, is free of irritation or allergens, has higher total yield and good safety and is suitable for industrial amplification.

Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1-5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).

Use of copper(II)/diamine catalysts in the desymmetrisation of?meso-diols and asymmetric Henry reactions: comparison of?(?)-sparteine and (+)-sparteine surrogates

Four new copper(II)/diamine complexes comprising some (+)-sparteine surrogates and a cyclohexane-derived diamine were prepared and evaluated as chiral catalysts in desymmetrisation of meso-diols and asymmetric Henry reactions. Mono-benzoylation reactions generated two products with high enantioselectivity (90:10 to 97:3 er). Asymmetric Henry reactions gave nitro alcohols in 90:10 to 98:2 er. Notably, the sense of induction with the (+)-sparteine surrogates was opposite to that obtained using the copper(II)/(?)-sparteine complex. One of the nitro alcohol products was utilised in a concise synthesis of a chiral morpholine.

POLYCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR

Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treati

COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR

Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein, R1, R2, A, Y, X, Ar1 and Ar2 have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.

SYNTHESIS AND ABSOLUTE CONFIGURATION OF SUBSTITUTED MORPHOLINES

We studied methods of stereospecific synthesis that enabled us to obtain variously substituted morpholinic compounds and to determine their absolute configuration.From a study of the chiroptical properties of synthetic N-(2-pyridyl-N-oxide) derivatives of optically active morpholines, it was possible to correlate the sign of the Cotton effect with the absolute configuration.This correlation agrees with that previously established for derivatives of the piperidine type.By evaluating the various contributions to the Cotton effect of substituents in positions 2 and 3, we established the absolute configuration of bicyclic compounds condensed in the two positions mentioned above.