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75277-39-3

HEPES sodium salt, also known as 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid sodium salt, is a zwitterionic buffer that does not bind to essential metal ions such as magnesium, calcium, manganese(II), or copper(II). It is a white powder and has been classified as a Good's buffer by Dr. Norman Good and his colleagues in 1966. HEPES is most effective in the pH range of 6.8 to 8.2 and is widely used in various applications due to its chemical properties.

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  • High quality N-(2-Hydroxyethyl)Piperazine-N’-(2-Ethanesulfonic Acid) Sodium Salt supplier in China

    Cas No: 75277-39-3

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  • 2000 Metric Ton/Year

  • Simagchem Corporation
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  • 75277-39-3 Structure

  • Basic information

    1. Product Name: HEPES sodium salt
    2. Synonyms: 2-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]ETHANESULFONIC ACID SODIUM SALT;2-[4-(2-HYDROXYETHYL)-1-PIPERAZINE]ETHANESULFONIC ACID SODIUM SALT;4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANESULFONIC ACID, DISODIUM SALT;4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANESULFONIC ACID HEMISODIUM SALT;4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANE-SULFONIC ACID HALF-SODIUM SALT;4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC ACID SODIUM SALT BUFFER;4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC ACID SODIUM SALT;4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANESULFONIC ACID, SODIUM SALT
    3. CAS NO:75277-39-3
    4. Molecular Formula: C8H17N2O4S*Na
    5. Molecular Weight: 260.29
    6. EINECS: 278-169-7
    7. Product Categories: Buffer;Biotechnology Performance Certified (BPC) BuffersBiological Buffers;Buffer SolutionsBiological Buffers;Good Buffers;Biological Buffers;Buffer Convenience Packaging;Buffers A to ZBiological Buffers
    8. Mol File: 75277-39-3.mol

  • Chemical Properties

    1. Melting Point: 234 °C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: White/dry powder
    5. Density: 1.504[at 20℃]
    6. Vapor Pressure: 0Pa at 25℃
    7. Refractive Index: N/A
    8. Storage Temp.: Store at RT.
    9. Solubility: H2O: 1 M at 20 °C, clear, colorless
    10. PKA: 7.5(at 25℃)
    11. Water Solubility: It is soluble in water.
    12. Sensitive: Hygroscopic
    13. Stability: Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents.
    14. CAS DataBase Reference: HEPES sodium salt(CAS DataBase Reference)
    15. NIST Chemistry Reference: HEPES sodium salt(75277-39-3)
    16. EPA Substance Registry System: HEPES sodium salt(75277-39-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany: 3
    5. RTECS:
    6. F: 3-10
    7. TSCA: Yes
    8. HazardClass: N/A
    9. PackingGroup: N/A
    10. Hazardous Substances Data: 75277-39-3(Hazardous Substances Data)

75277-39-3 Usage

Uses

Used in Cell Culture Studies:
HEPES sodium salt is used as a buffer in cell culture studies to maintain a stable pH environment, which is crucial for cell growth and function.
Used in Buffer Preparation:
HEPES sodium salt is used in the preparation of HEPES buffer solution, which is essential for various biological and chemical experiments.
Used in Phosphorylation Assays:
HEPES sodium salt is used as a buffer during phosphorylation assays in permeabilized fibroblasts, ensuring a stable pH environment for accurate results.
Used in Complex Dialysis Buffer Composition:
HEPES sodium salt is used to compose a complex dialysis buffer, which is utilized in the determination of free thyroxin in serum by radioimmunoassay.
Used in Pharmaceutical and Biotechnology Industries:
HEPES sodium salt is used as a buffering agent in the pharmaceutical and biotechnology industries for various applications, including drug formulation and stability testing.
Used in Research and Development:
HEPES sodium salt is used in research and development for maintaining a stable pH environment in various biochemical and cellular assays, contributing to accurate and reliable results.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 75277-39-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,2,7 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 75277-39:
(7*7)+(6*5)+(5*2)+(4*7)+(3*7)+(2*3)+(1*9)=153
153 % 10 = 3
So 75277-39-3 is a valid CAS Registry Number.

75277-39-3 Well-known Company Product Price

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  • Alfa Aesar

  • (A16516)  HEPES sodium salt, 99%   

  • 75277-39-3

  • 25g

  • 266.0CNY

  • Detail

  • Alfa Aesar

  • (A16516)  HEPES sodium salt, 99%   

  • 75277-39-3

  • 100g

  • 700.0CNY

  • Detail

  • Alfa Aesar

  • (M10340)  HEPES (Sodium Salt), 99%   

  • 75277-39-3

  • 500g

  • 1695.0CNY

  • Detail

75277-39-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate

1.2 Other means of identification

Product number -
Other names HEPES sodium salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75277-39-3 SDS

75277-39-3Synthetic route

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

sodium 2-hydroxyethanesulfonate
1562-00-1

sodium 2-hydroxyethanesulfonate

4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid sodium salt
75277-39-3

4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid sodium salt

Conditions
ConditionsYield
sodium hydroxide at 204℃; under 4793.91 Torr; for 2.25h; Product distribution / selectivity; Autoclave;94.6%
sodium hydroxide In water at 140 - 200℃; under 1587.51 - 5414.51 Torr; for 2 - 72h; Product distribution / selectivity; Autoclave;6%

75277-39-3Downstream Products

75277-39-3Relevant articles and documents

Preparation of substituted alkanesulfonates from 2-hydroxyalkanesulfonates

-

Page/Page column 4-6, (2008/06/13)

The present invention relates to a process for the preparation of substituted alkanesulfonates by the reaction of an aqueous metal substituted 2-hydroxyethanesulfonate with a nucleophile. 2-Alkylaminoalkanesulfonate is formed when the nucleophile is an amine. The invention also relates to the optimization of reaction conditions to produce an optimum yield.

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