Relevant articles and documents
All total 9 Articles be found
Synthesis method of 2-chloropyrimidine-4-formic acid
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Paragraph 0024-0028, (2020/07/21)
The invention relates to a synthesis method of 2-chloropyrimidine-4-formic acid. 2, 4-dichloropyrimidine is used as a starting raw material, the target product 2-chloropyrimidine-4-formic acid is prepared through a two-step reaction, and the whole synthesis process is high in yield, the purity is good, and the operation is convenient, green and environmentally friendly, therefore the method is suitable for industrial production.
NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK
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Paragraph 0110, (2017/04/04)
The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases s
COMPOSITIONS AND METHODS FOR TREATING CANCER
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Page/Page column 39, (2013/03/28)
The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.