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75833-38-4

75833-38-4

Identification

Synonyms:2-Chloro-4-cyanopyrimidine;NSC 59978;2-chloropyrimidine-4-carbonitrile;4-Pyrimidinecarbonitrile, 2-chloro-;Pyrimidine-4-carbonitrile, 2-chloro-;

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Safety information and MSDS view more

  • Pictogram(s):Xn

  • Hazard Codes:Xn

  • Signal Word:Warning

  • Hazard Statement:H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaledH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
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  • Manufacture/Brand:Usbiological
  • Product Description:2-Chloro-4-pyrimidinecarbonitrile
  • Packaging:250mg
  • Price:$ 347
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:2-Chloropyrimidine-4-carbonitrile
  • Packaging:1g
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:2-Chloropyrimidine-4-carbonitrile 95+%
  • Packaging:1 g
  • Price:$ 365
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  • Product Description:2-Chloro-4-pyrimidinecarbonitrile >95%
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  • Price:$ 740
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Chloro-4-pyrimidinecarbonitrile >95%
  • Packaging:5g
  • Price:$ 235
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Chloro-4-pyrimidinecarbonitrile >95%
  • Packaging:1g
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  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:2-Chloropyrimidine-4-carbonitrile 97%
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  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:2-Chloropyrimidine-4-carbonitrile 97%
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  • Product Description:2-Chloropyrimidine-4-carbonitrile 98%
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  • Manufacture/Brand:Chemenu
  • Product Description:2-chloropyrimidine-4-carbonitrile 98%
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Relevant articles and documentsAll total 9 Articles be found

Synthesis method of 2-chloropyrimidine-4-formic acid

-

Paragraph 0024-0028, (2020/07/21)

The invention relates to a synthesis method of 2-chloropyrimidine-4-formic acid. 2, 4-dichloropyrimidine is used as a starting raw material, the target product 2-chloropyrimidine-4-formic acid is prepared through a two-step reaction, and the whole synthesis process is high in yield, the purity is good, and the operation is convenient, green and environmentally friendly, therefore the method is suitable for industrial production.

NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK

-

Paragraph 0110, (2017/04/04)

The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases s

COMPOSITIONS AND METHODS FOR TREATING CANCER

-

Page/Page column 39, (2013/03/28)

The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.

Process route upstream and downstream products

Process route

2-hydroxy-pyrimidine-4-carbaldehyde oxime
7460-56-2

2-hydroxy-pyrimidine-4-carbaldehyde oxime

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 100 ℃;
69%
With phosphorus trichloride; for 4h;
60%
With trichlorophosphate; at 45 - 70 ℃; for 3h;
30%
With trichlorophosphate; at 45 - 70 ℃; for 3h;
30%
2-oxo-1,2-dihydro-pyrimidine-4-carbaldehyde oxime
7460-56-2

2-oxo-1,2-dihydro-pyrimidine-4-carbaldehyde oxime

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

Conditions
Conditions Yield
2-oxo-1,2-dihydro-pyrimidine-4-carbaldehyde oxime; With trichlorophosphate; at 0 - 20 ℃; for 0.5h;
With N,N-diethylaniline; for 0.5h; Reflux;
86.5%
With N,N-diethylaniline; trichlorophosphate; for 0.5h; Heating / reflux;
zinc(II) cyanide
557-21-1

zinc(II) cyanide

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

Conditions
Conditions Yield
tetrakis(triphenylphosphine) palladium(0); In N,N-dimethyl-formamide; at 120 ℃; for 2.08333h; Inert atmosphere;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

2-hydroxy-2-methylpropanenitrile
75-86-5

2-hydroxy-2-methylpropanenitrile

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

Conditions
Conditions Yield
With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; nickel(I) bromide; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 6h; Reagent/catalyst; Temperature;
2-hydroxy-4-pyrimidinecarboxaldehyde
950514-12-2

2-hydroxy-4-pyrimidinecarboxaldehyde

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

Conditions
Conditions Yield
In dichloromethane; water; N,N-dimethyl-aniline;
2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

Conditions
Conditions Yield
2-Hydroxy-4-oximinomethyl-pyrimidin, 1. POCl3, vors. Erhitzen bis zur exothermen Rk. 2. N,N-Dimethyl-anilin (Siedetemp., 30 min), 3. Hydrolyse;
(2), POCl3;
2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

2-chloro-4-pyrimidinecarboxamide
22536-66-9

2-chloro-4-pyrimidinecarboxamide

Conditions
Conditions Yield
With sulfuric acid;
With hydrogenchloride; formic acid; In nitromethane; ethyl acetate;
With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;
(S)-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(piperazin-1-yl)methanone

(S)-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(piperazin-1-yl)methanone

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

(S)-2-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperazin-1-yl)pyrimidine-4-carbonitrile

(S)-2-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperazin-1-yl)pyrimidine-4-carbonitrile

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 70 ℃; for 32h;
100%
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 70 ℃; for 32h;
100%
(1s,4s)-4-aminocyclohexan-1-ol hydrochloride
56239-26-0

(1s,4s)-4-aminocyclohexan-1-ol hydrochloride

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

2-(((1s,4s)-4-hydroxycyclohexyl)amino)pyrimidine-4-carbonitrile

2-(((1s,4s)-4-hydroxycyclohexyl)amino)pyrimidine-4-carbonitrile

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 4h;
95%
N-tert-butyl-1-(3,5-dichlorophenyl)-7-methoxy-N-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamide

N-tert-butyl-1-(3,5-dichlorophenyl)-7-methoxy-N-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamide

2-chloro-pyrimidine-4-carbonitrile
75833-38-4

2-chloro-pyrimidine-4-carbonitrile

N-tert-butyl-8-(4-cyanopyrimidin-2-yl)-1-(3,5-dichlorophenyl)-7-methoxy-N-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamide

N-tert-butyl-8-(4-cyanopyrimidin-2-yl)-1-(3,5-dichlorophenyl)-7-methoxy-N-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamide

Conditions
Conditions Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; In 1,4-dioxane; water; at 90 ℃; for 2h; Inert atmosphere; Microwave irradiation;
75%

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