1124-75-0

Basic information

• Product Name: 2-methylsulfanylpyrimidine-4-carbonitrile
• Synonyms: 2-methylsulfanylpyrimidine-4-carbonitrile;2-(Methylthio)-4-pyrimidinecarbonitrile;2-(Methylthio)pyriMidine-4-carbonitrile
• CAS NO: 1124-75-0
• Molecular Formula: C6H5N3S
• Molecular Weight: 151.19
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 1124-75-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 311.4°Cat760mmHg
• Flash Point: 142.1°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 0.000566mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-methylsulfanylpyrimidine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylsulfanylpyrimidine-4-carbonitrile(1124-75-0)
• EPA Substance Registry System: 2-methylsulfanylpyrimidine-4-carbonitrile(1124-75-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 1124-75-0(Hazardous Substances Data)

Usage

General Description

2-Methylsulfanylpyrimidine-4-carbonitrile is a chemical compound with the molecular formula C7H6N4S. It is a pyrimidine derivative with a methylsulfanyl group attached to the 2-position and a cyano group attached to the 4-position of the pyrimidine ring. 2-methylsulfanylpyrimidine-4-carbonitrile is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs and pesticides. 2-Methylsulfanylpyrimidine-4-carbonitrile may also be utilized in organic chemistry research and in the production of specialty chemicals. Due to its unique molecular structure, this compound has properties that make it useful in a variety of chemical reactions and industrial processes.

InChI:InChI=1/C6H5N3S/c1-10-6-8-3-2-5(4-7)9-6/h2-3H,1H3

Upstream product

• 13435-20-6 tetraethylammoniumcyanide 
• 6622-64-6 Trimethyl-4-(2-methylthiopyrimidinyl)ammoniumchlorid 
• 75833-38-4 2-chloro-pyrimidine-4-carbonitrile 
• 5188-07-8 sodium thiomethoxide 
• 1122-74-3 4-iodo-2-(methylthio)pyrimidine 
• 544-92-3 copper(I) cyanide 
• 49844-90-8 4-Chloro-2-methylthiopyrimidine 

Relevant articles and documents

Structure–Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa

Drug-resistant Pseudomonas aeruginosa (PA) strains are on the rise, making treatment with current antibiotics ineffective. Hence, circumventing resistance or restoring the activity of antibiotics by novel approaches is of high demand. Targeting the Pseudomonas quinolone signal quorum sensing (PQS-QS) system is an intriguing strategy to abolish PA pathogenicity without affecting the viability of the pathogen. Herein we report the structure–activity relationships of 2-sulfonylpyrimidines, which were previously identified as dual-target inhibitors of the PQS receptor PqsR and the PQS synthase PqsD. The SAR elucidation was guided by a combined approach using ligand efficiency and ligand lipophilicity efficiency to select the most promising compounds. In addition, the most effective inhibitors were rationally modified by the guidance of QSAR using Hansch analyses. Finally, these inhibitors showed the capacity to decrease biofilm mass and extracellular DNA, which are important determinants for antibiotic resistance.

1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF

This invention provides a compound represented by the formula (I) :wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents;R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents;n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I) , which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.