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76045-71-1

76045-71-1

Identification

  • Product Name:Benzoic acid,3-amino-5-hydroxy-

  • CAS Number: 76045-71-1

  • EINECS:

  • Molecular Weight:153.137

  • Molecular Formula: C7H7NO3

  • HS Code:2922509090

  • Mol File:76045-71-1.mol

Synonyms:3-Amino-5-hydroxybenzoic acid;3-Hydroxy-5-aminobenzoic acid;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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  • Manufacture/Brand:TRC
  • Product Description:3-Amino-5-hydroxybenzoicAcid
  • Packaging:250mg
  • Price:$ 40
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  • Product Description:3-Amino-5-hydroxybenzoicacid 97%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:3-AMINO-5-HYDROXY BENZOIC ACID 95.00%
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Relevant articles and documentsAll total 8 Articles be found

As neuroprotective agents of pharmaceutical compounds

-

, (2019/06/26)

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Halide-guided oligo(aryl-triazole-amide)s foldamers: Receptors for multiple halide ions

Wang, Ying,Xiang, Junfeng,Jiang, Hua

supporting information; experimental part, p. 613 - 619 (2011/03/18)

We synthesized and characterized a series of oligo(phenyl-amide-triazole)s that can fold into a helical conformation guided by halide ions. Their binding models and affinities are highly dependent on the length of the foldamer, media and the inducing capa

Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin c

Chamberland, Stephen,Grueschow, Sabine,Sherman, David H.,Williams, Robert M.

supporting information; experimental part, p. 791 - 794 (2009/08/15)

Beyond the identification of 3-amino-5-hydroxybenzoic acid (AHBA) and D-glucosamine as biosynthetic precursors to mitomycin C (5) and FR900482 (6), little is known about the pathway Nature uses to prepare these antitumor antibiotics. To gain some insight

Pilot-plant preparation of an αvβ3 integrin antagonist. Part 2. Synthesis of N-[2-(5-hydroxy-4,6- tetrahydropyrimidine)]-3-amino-5-hydroxybenzoic acid

Clark, Jerry D.,Collins, Joe T.,Kleine, H. Peter,Weisenburger, Gerald A.,Anderson, D. Keith

, p. 571 - 575 (2013/09/02)

Studies directed toward the process research and development of a scalable method for preparing tetrahydropyrimidine 2, a key intermediate to the αvβ3 integrin antagonist 1, are described. A linear approach employing 3-amino-5-hydrox

Kanosamine biosynthesis: A likely source of the aminoshikimate pathway's nitrogen atom

Guo, Jiantao,Frost

, p. 10642 - 10643 (2007/10/03)

The biosynthetic source of the nitrogen atom incorporated into the aminoshikimate pathway has remained a question for some time. 3-Amino-3-deoxy-d-fructose 6-phosphate has previously been demonstrated to be a precursor to 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate and 3-amino-5-hydroxybenzoic acid via the inferred intermediacy of 1-deoxy-1-imino-d-erythrose 4-phosphate in Amycolatopsis mediterranei cell-free extract. This investigation examines the possibility that the natural product kanosamine might be a precursor to 3-amino-3-deoxy-d-fructose 6-phosphate. Kanosamine 6-phosphate was synthesized by a chemoenzymatic route and incubated in A. mediterranei cell-free lysate along with d-ribose 5-phosphate and phosphoenolpyruvate. Formation of 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate and 3-amino-5-hydroxybenzoic acid was observed. Subsequent incubation in A. mediterranei cell-free lysate of glutamine and NAD with UDP-glucose resulted in the formation of kanosamine. The bioconversion of UDP-glucose into kanosamine along with the bioconversion of kanosamine 6-phosphate into 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate and 3-amino-5-hydroxybenzoic acid suggests that kanosamine biosynthesis is the source of the aminoshikimate pathway's nitrogen atom. Copyright

Process route upstream and downstream products

Process route

3-hydroxy-5-nitrobenzoic acid
78238-14-9

3-hydroxy-5-nitrobenzoic acid

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In ethanol; for 0.25h; under 760 Torr;
100%
With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 1.5h;
88%
With ammonium iron (II) sulfate; ammonia; In water; at 120 ℃; for 0.166667h;
45%
With palladium on activated charcoal; hydrogen; In methanol; for 2h; under 760.051 Torr;
5-deoxy-5-amino-3-dehydroshikimic acid
141726-22-9

5-deoxy-5-amino-3-dehydroshikimic acid

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
With Tris buffer; at 28 ℃; for 10h; cell-free extract of N. mediterranei;
95%
3,5-Dihydroxybenzoic acid
99-10-5

3,5-Dihydroxybenzoic acid

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 1.) NH4Cl, NH4OH, 2.) 6N HCl / 1.) 180 deg C, 40 h, under pressure, 2.) reflux, 16 h
2: 96 percent / 2N NaOH / H2O
With hydrogenchloride; ammonium hydroxide; sodium hydroxide; ammonium chloride; In water;
3,5-Dihydroxybenzoic acid; With ammonium hydroxide; ammonium chloride; at 180 - 190 ℃; under 19636.5 - 23049.7 Torr; Large scale;
With hydrogenchloride; In water; at 100 - 112 ℃; Large scale;
3-amino-5-hydroxybenzoic acid hydrochloride
14206-69-0

3-amino-5-hydroxybenzoic acid hydrochloride

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
With sodium hydroxide; In water;
96%
phosphoenolpyruvic acid
138-08-9

phosphoenolpyruvic acid

3-amino-3-deoxy-D-glucopyranose-6-phosphate

3-amino-3-deoxy-D-glucopyranose-6-phosphate

3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate
61857-46-3

3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

4-amino-3,4-dideoxy-D-arabino-heptulosonic acid 7-phosphate

4-amino-3,4-dideoxy-D-arabino-heptulosonic acid 7-phosphate

Conditions
Conditions Yield
With A. mediterranei cell-free extract (DAHP synthase activity); at 28 ℃; for 6h; pH=7.3;
20 % Spectr.
6 % Spectr.
2 % Spectr.
methyl 3,5-dinitrobenzoate
2702-58-1

methyl 3,5-dinitrobenzoate

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 63 percent / MeOLi / 4 h / Heating
2: 79 percent / 48percent aq. HBr, AcOH / 22 h / Heating
3: 100 percent / H2 / 10percent Pd/C / ethanol / 0.25 h / 760 Torr
With lithium methanolate; hydrogen bromide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol;
3-methoxy-5-nitrobenzoic acid methyl ester
78238-13-8

3-methoxy-5-nitrobenzoic acid methyl ester

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 79 percent / 48percent aq. HBr, AcOH / 22 h / Heating
2: 100 percent / H2 / 10percent Pd/C / ethanol / 0.25 h / 760 Torr
With hydrogen bromide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol;
3,5-dinitrobenzoic acid
99-34-3

3,5-dinitrobenzoic acid

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: iron; acetic acid
2.1: sulfuric acid; sodium nitrite / water / 0 °C
2.2: 0.03 h / 20 °C
3.1: ammonium iron (II) sulfate; ammonia / water / 0.17 h / 120 °C
With ammonium iron (II) sulfate; sulfuric acid; ammonia; iron; acetic acid; sodium nitrite; In water;
Multi-step reaction with 3 steps
1.1: 0.25 h / -78 °C
1.2: 24 h / 20 - 80 °C
2.1: boron tribromide / dichloromethane / 15 h / -10 - 20 °C
3.1: hydrogen; palladium on activated charcoal / methanol / 2 h / 760.05 Torr
With palladium on activated charcoal; hydrogen; boron tribromide; In methanol; dichloromethane;
3-amino-5-nitro-benzoic acid
618-84-8

3-amino-5-nitro-benzoic acid

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: sulfuric acid; sodium nitrite / water / 0 °C
1.2: 0.03 h / 20 °C
2.1: ammonium iron (II) sulfate; ammonia / water / 0.17 h / 120 °C
With ammonium iron (II) sulfate; sulfuric acid; ammonia; sodium nitrite; In water;
benzoic acid
65-85-0,8013-63-6

benzoic acid

3-amino-5-hydroxybenzoic acid
76045-71-1

3-amino-5-hydroxybenzoic acid

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / 25 h / 135 °C
2.1: 0.25 h / -78 °C
2.2: 24 h / 20 - 80 °C
3.1: boron tribromide / dichloromethane / 15 h / -10 - 20 °C
4.1: hydrogen; palladium on activated charcoal / methanol / 2 h / 760.05 Torr
With sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; boron tribromide; In methanol; dichloromethane;

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