761443-50-9

Usage

Uses

Used in Pharmaceutical Industry:
1-Ethyloxycarbonyl-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-pyrrolo[3,4-c]pyrazole is used as a potential pharmacological agent for drug development due to its ability to interact with biological targets. Its unique structure may contribute to the discovery of new therapeutic agents or the enhancement of existing ones.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-Ethyloxycarbonyl-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-pyrrolo[3,4-c]pyrazole serves as a compound of interest for further study. Its structural features and potential interactions with biological targets make it a candidate for the development of new drugs or the improvement of existing pharmaceuticals.

Upstream product

• 266353-18-8 N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester 
• 175463-32-8 3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 398495-65-3 3-amino-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester 
• 761443-69-0 5-tert-butyl 1-ethyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate 
• 3088-42-4 N-(2-cyanoethyl)glycine 
• 398491-59-3 3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 
• 44981-94-4 N-cyanoethyl glycine ethyl ester 

Downstream Products

• 916995-51-2 danusertib 
• 1430587-71-5 C₂₄H₂₆N₆O₂ 
• 850997-40-9 C₂₄H₂₇N₇O₂ 
• 1430587-20-4 C₂₇H₃₁N₇O₄ 
• 948019-51-0 C₂₄H₂₈N₆O₃S 

Relevant academic research and scientific papers

(R)- N - [5 - (2 - methoxy - 2 - phenyl-acetyl) - 1, 4, 5, 6 - tetrahydro-pyrrolo [3, 4 - c] pyrazole - 3 - yl] - 4 - (4 - methyl piperazine - 1 - yl) benzamide synthesis method

The invention belongs to the technical field of medicine and relates to a preparation method for PHA739358(Danusertib), i.e., (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide. According to the invention, altogether four reaction routes are designed, simple and easily available glycine is used as a raw material, reactions like addition, esterification, amino protection and cyclization are carried out so as to prepare (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide, yield of the route 1, 2 and 4 is more than 25%, respectively, and yield of the route 3 is more than 20%. The preparation method has the advantages of a few reaction steps, simple and convenient post-treatment operation, little time consumption, high yield and low total cost. Thus, a novel method is provided for preparation of the antitumor drug PHA739358.

BICYCLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Compounds which are pyrrolo-pyrazole derivatives and pharmaceutically acceptable salts thereof, together with the process for their preparation and pharmaceutical compositions thereof are disclosed; these compounds or compositions are useful in the treatm