76273-44-4Relevant articles and documents
Baker's yeast catalyzed synthesis of 1,4-benzothiazines, performed under ultrasonication
Pratap, Umesh R.,Jawale, Dhanaji V.,Londhe, Balaji S.,Mane, Ramrao A.
experimental part, p. 94 - 97 (2011/07/07)
An efficient and simple one pot method has been developed for the synthesis of 1,4-benzothiazines by allowing the condensation of 2-aminobenzenethiols and 1,3-dicarbonyls using cheaper biocatalyst, baker's yeast. The role of ultrasonication in the rate expediting of the condensation has been discussed.
Synthesis of a series of 2,3-disubstituted 4H-1,4-benzothiazines and X-ray crystal structure of ethyl 7-chloro-3-methyl-4H-1,4-benzothiazine-2-carboxylate
Dandia, Anshu,Sarawgi, Pritima,Hursthouse, Michael B.,Bingham, Ann L.,Light, Mark E.,Drake, John E.,Ratnani, Raju
, p. 445 - 448 (2007/10/03)
The reaction between 2-aminobenzenethiol and ethyl acetoacetate is studied under a variety of conditions, and a procedure for the exclusive synthesis of 1,4-benzothiazines by the neat reaction of substituted aminothiols with β-ketoesters and β-dicarbonyl compounds in 85-96% yield is described. With microwave heating, even when both the reactants are solid, yields are high, reaction times brief, and work-up easy. A facile reaction is also observed even in a solid-state reaction. The molecular structure of ethyl 7-chloro-3-methyl-4H-1,4-benzothiazine-2-carboxylate (4d) was determined by single-crystal X-ray diffraction.
Synthesis of new 4-thiazolidinones bearing potentially active heteryl moities
Ingle,Sawale,Ingle,Mane
, p. 124 - 128 (2007/10/03)
2-Acyl-3-methyl-7-substituted-1,4-benzothiazines 1A and 5-acyl-1-aryl-2-mercapto-4-methylimidazoles 1B have been converted to their respective hydrazones 2A and 2B by refluxing them with hydrazine hydrate in digol. The hydrazino derivatives on condensation with aryl isothiocyanates give asymmetric thioureas 3A and 3B. The thioureas when refluxed with monochloroacetic acid in glacial acetic acid using anhydrous sodium acetate as catalyst yield the title products, 2-[(-3′-methyl-4H-7′-substituted-1,4-benzothiazin-2′-yl) -methyl-ketoiminyl]imino-3-aryl-4-thiazolidinones 4A and 2-[(l′-substituted phenyl-2′-mercapto-4′-methylimidazol-5′-yl) -methyl-ketoiminyl]imino-3-substituted phenyl-4-thiazolidinones 4B. Some of the newly synthesised compounds have been screened against Alternaria brassicae, Gloeosporium ampelophagum and Fusarium oxysporium and the results are presented.
Dry media synthesis of 4H-1, 4-benzothiazines under microwave irradiation using basic alumina as solid support
Paul,Gupta,Loupy,Rani,Dandia
, p. 711 - 717 (2007/10/03)
A simple and efficient method has been developed for the rapid synthesis of substituted 4H-1, 4-benzothiazines (3) from 2-aminobenzenethiols (1) and β-ketoester/ β-diketones (2) in dry media under microwave irradiation using basic alumina as solid support.
A CONVENIENT AND SINGLE STEP SYNTHESIS OF SUBSTITUTED 4H-BENZOTHIAZINES.
Gupta, R. R.,Ojha, K. G.,Kalwania, G. S.,Kumar, M.
, p. 1145 - 1149 (2007/10/02)
A simple one step synthesis is reported for substituted 4H-benzothiazines involving the condensation of 5-(chloro, bromo, methyl, methoxy, ethoxy)-, 4-methyl- and 3-(chloro and methoxy)-2-aminobenzenethiols with acetylacetone/ethyl acetoacetate/dibenzoylmethane in DMSO.
