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76308-26-4

76308-26-4

Identification

  • Product Name:Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride

  • CAS Number: 76308-26-4

  • EINECS:

  • Molecular Weight:221.727

  • Molecular Formula: C10H20ClNO2

  • HS Code:2922499990

  • Mol File:76308-26-4.mol

Synonyms:Cyclohexa; Trans-Methyl 4-aminocyclohexanecarboxylate HCl

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:Ethyltrans-2-(4-aminocyclohexyl)acetatehydrochloride
  • Packaging:500mg
  • Price:$ 50
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
  • Packaging:1G
  • Price:$ 107
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
  • Packaging:5G
  • Price:$ 346
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  • Manufacture/Brand:Crysdot
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride 95+%
  • Packaging:25g
  • Price:$ 810
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  • Manufacture/Brand:Crysdot
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride 95+%
  • Packaging:5g
  • Price:$ 266
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  • Manufacture/Brand:Chemenu
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride 95%
  • Packaging:1g
  • Price:$ 102
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  • Manufacture/Brand:Chemenu
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride 95%
  • Packaging:5g
  • Price:$ 327
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  • Manufacture/Brand:Chemenu
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride 95%
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  • Manufacture/Brand:Chemenu
  • Product Description:Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride 95%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:ETHYL-2-(TRANS-4-AMINOCYCLOHEXYL)ACETATE HYDROCHLORIDE 95.00%
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Relevant articles and documentsAll total 4 Articles be found

PROCESS FOR THE PREPARATION OF TRANS 4-AMINO-CYCLOHEXYL ACETIC ACID ETHYL ESTER HCL

-

Page/Page column 4, (2010/08/05)

The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein d) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-500C in the presence of Pd/C under 0.1-0.6 bar overpres

BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS

-

Page/Page column 10, (2009/03/07)

The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.

Aminopyrimidines with high affinity for both serotonin and dopamine receptors

Wustrow, David,Belliotti, Thomas,Glase, Shelly,Kesten, Suzanne Ross,Johnson, Don,Colbry, Norman,Rubin, Ronald,Blackburn, Anthony,Akunne, Hyacinth,Corbin, Ann,Duff Davis,Georgic, Lynn,Whetzel, Steven,Zoski, Kim,Heffner, Thomas,Pugsley, Thomas,Wise, Lawrence

, p. 760 - 771 (2007/10/03)

A series of {4-[2-(4-arylpiperazin-1-yl)alkyl]cyclohexyl}pyrimidin-2- ylamines was prepared and found to have receptor binding affinity for D2 and D3 dopamine (DA) receptors and serotonin 5-HT1A receptors. The structural contributions to D2/D3 and 5-HT1A

cis- AND trans-4-AMINOCYCLOHEXYLACETIC ACIDS AND THEIR DIETHYLENIMIDO(THIO)PHOSPHORYL DERIVATIVES

Karpavichyus, K. I.,Palaima, A. I.,Knunyants, I. L.

, p. 1689 - 1694 (2007/10/02)

-

Process route upstream and downstream products

Process route

ethanol
64-17-5

ethanol

4-nitrobenzeneacetic acid
104-03-0

4-nitrobenzeneacetic acid

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

Conditions
Conditions Yield
4-nitrobenzeneacetic acid; With hydrogen; palladium 10% on activated carbon; In water; at 44 - 58 ℃; Inert atmosphere; Autoclave; Industry scale;
ethanol; With hydrogenchloride; In water; Reflux; Industry scale;
40%
With hydrogenchloride; sodium hydroxide; hydrogen; nickel; Yield given. Multistep reaction;
ethanol
64-17-5

ethanol

trans-4-aminocyclohexylacetic acid hydrochloride
76325-96-7,109572-36-3

trans-4-aminocyclohexylacetic acid hydrochloride

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

Conditions
Conditions Yield
hydrogenchloride; for 4h; Heating / reflux;
ETHYL 4-NITROPHENYLACETATE
5445-26-1

ETHYL 4-NITROPHENYLACETATE

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 1139 g / H2, aq. NaOH / Raney Ni / 62.5 h / 20 - 130 °C / 91380.1 - 129701 Torr
2: HCl / 4 h / Heating
With hydrogenchloride; sodium hydroxide; hydrogen; nickel;
ethanol
64-17-5

ethanol

trans-(4-amino-cyclohexyl)-acetic acid
1197-54-2

trans-(4-amino-cyclohexyl)-acetic acid

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; for 4h; Yield given; Heating;
acetyl chloride
75-36-5

acetyl chloride

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

trans-ethyl 2-(4-acetamidocyclohexyl)acetate
946598-99-8

trans-ethyl 2-(4-acetamidocyclohexyl)acetate

Conditions
Conditions Yield
acetyl chloride; ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 5h;
With sodium hydrogencarbonate; In dichloromethane; water;
78%
4-bromo-2-nitrobenzaldehyde
5551-12-2

4-bromo-2-nitrobenzaldehyde

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

ethyl 2-((1r,4r)-4-(6-bromo-2H-indazol-2-yl)cyclohexyl)acetate

ethyl 2-((1r,4r)-4-(6-bromo-2H-indazol-2-yl)cyclohexyl)acetate

Conditions
Conditions Yield
ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride; With triethylamine; In isopropyl alcohol; at 25 ℃; for 0.1h; Inert atmosphere;
4-bromo-2-nitrobenzaldehyde; In isopropyl alcohol; at 80 ℃; for 4h; Inert atmosphere;
With tributylphosphine; In isopropyl alcohol; at 80 ℃; for 16h; Inert atmosphere;
78%
5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridine-7-carboxylic acid

5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridine-7-carboxylic acid

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

ethyl 2-((1r,4r)-4-(5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)cyclohexyl)acetate

ethyl 2-((1r,4r)-4-(5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)cyclohexyl)acetate

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
61%
cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid
1153862-00-0

cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

(trans-4-{2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetylamino}-cyclohexyl)-acetic acid ethyl ester
1221227-58-2

(trans-4-{2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetylamino}-cyclohexyl)-acetic acid ethyl ester

Conditions
Conditions Yield
cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 40 ℃; for 0.25h;
ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride; In N,N-dimethyl-formamide; at 50 ℃; for 2h;
With sodium hydrogencarbonate; In water; pH=6;
7-chloro-6-nitrothieno[3,2-b]pyridine
110651-92-8

7-chloro-6-nitrothieno[3,2-b]pyridine

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

ethyl {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetate
1607590-79-3

ethyl {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetate

Conditions
Conditions Yield
With triethylamine; In isopropyl alcohol; at 100 ℃; for 1h;
2-chloropyrimidine
1722-12-9,1195939-87-7

2-chloropyrimidine

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride
76308-26-4

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

[4-(Pyrimidin-2-ylamino)-cyclohexyl]-acetic acid ethyl ester
189153-07-9

[4-(Pyrimidin-2-ylamino)-cyclohexyl]-acetic acid ethyl ester

Conditions
Conditions Yield
With triethylamine; In ethanol; for 18h; Heating;
71%

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